Infrared studies of supernova remnants with the IRAS

A comparative study of the infrared and X-ray fluxes and morphologies of supernova remnants (SNR) can yield valuable information on their evolution and on their interaction with the smbient interstellar medium (ISM)

Soft X-ray Emission from the Spiral Galaxy NGC 1313

The nearby barred spiral galaxy NGC 1313 has been observed with the PSPC instr- ument on board the ROSAT X-ray satellite. Ten individual sources are found. Three sources (X-1, X-2 and X-3 [SN~1978K]) are very bright (~10^40 erg/s) and are unusual in that analogous objects do not exist in our Galaxy. We present an X-ray image of NGC~1313 and \xray spectra for the three bright sources. The emission from the nuclear region (R ~< 2 kpc) is dominated by source X-1, which is located ~1 kpc north of the photometric (and dynamical) center of NGC~1313. Optical, far-infrared and radio images do not indicate the presence of an active galactic nucleus at that position; however, the compact nature of the \xray source (X-1) suggests that it is an accretion-powered object with central mass M >~ 10^3 Msun. Additional emission (L_X ~ 10^39 erg/s) in the nuclear region extends out to ~2.6 kpc and roughly follows the spiral arms. This emission is from 4 sources with luminosity of several x 10^38 erg/s, two of which are consistent with emission from population I sources (e.g., supernova remnants, and hot interstellar gas which has been heated by supernova remnants). The other two sources could be emission from population II sources (e.g., low-mass \xray binaries). The bright sources X-2 and SN~1978K are positioned in the southern disk of NGC~1313. X-2 is variable and has no optical counterpart brighter than 20.8 mag (V-band). It is likely that it is an accretion-powered object in NGC~1313. The type-II supernova SN~1978K (Ryder \etal 1993) has become extra- ordinarily luminous in X-rays $\sim$13 years after optical maximum.Comment: to appear in 10 Jun 1995 ApJ, 30 pgs uuencoded compressed postscript, 25 pgs of figures available upon request from colbert, whole preprint available upon request from Sandy Shrader ([email protected]), hopefully fixed unknown problem with postscript fil

A Deep ROSAT HRI Observation of NGC 1313

We describe a series of observations of NGC 1313 using the ROSAT HRI with a combined exposure time of 183.5 ksec. The observations span an interval between 1992 and 1998; the purpose of observations since 1994 was to monitor the X-ray flux of SN1978K, one of several luminous sources in the galaxy. No diffuse emission is detected in the galaxy to a level of ~1-2x10^37 ergs/s/arcmin^-2. A total of eight sources are detected in the summed image within the D_25 diameter of the galaxy. The luminosities of five of the eight range from \~6x10^37 to ~6x10^38 erg/s; these sources are most likely accreting X-ray binaries, similar to sources obseved in M31 and M33. The remaining three sources all emit above 10^39 erg/s. We present light curves of the five brightest sources. Variability is detected at the 99.9% level from four of these. We identify one of the sources as an NGC 1313 counterpart of a Galactic X-ray source. The light curve, though crudely sampled, most closely resembles that of a Galactic black hole candidate such as GX339-4, but with considerably higher peak X-ray luminosity. An additional seven sources lie outside of the D_25 diameter and are either foreground stars or background AGN.Comment: 18 pages, 9 figures; accepted AJ, scheduled for November 200

X-ray Variability from the Compact Source in the Supernova Remnant RCW 103

A new ASCA observation of 1E 161348-5055, the central compact X-ray source in the supernova remnant RCW 103, reveals an order-of-magnitude decrease in its 3 - 10 keV flux since the previous ASCA measurement four years earlier. This result is hard to reconcile with suggestions that the bulk of the emission is simple quasi-blackbody, cooling radiation from an isolated neutron star. Furthermore, archived EINSTEIN and ROSAT datasets spanning 18 years confirm that this source manifests long-term variability, to a lesser degree. This provides a natural explanation for difficulties encountered in reproducing the original EINSTEIN detection of 1E 161348-5055. Spectra from the new data are consistent with no significant spectral change despite the decline in luminosity. We find no evidence for a pulsed component in any of the data sets, with a best upper limit on the pulsed modulation of 13 percent. We discuss the phenomenology of this remarkable source.Comment: 5 pages with 2 embedded figures, LaTex, emulateapj.sty. To appear in the Astrophysical Journal Letter

Chandra X-ray Observation of a Mature Cloud-Shock Interaction in the Bright Eastern Knot Region of Puppis A

We present Chandra X-ray images and spectra of the most prominent cloud-shock interaction region in the Puppis A supernova remnant. The Bright Eastern Knot (BEK) has two main morphological components: (1) a bright compact knot that lies directly behind the apex of an indentation in the eastern X-ray boundary and (2) lying 1' westward behind the shock, a curved vertical structure (bar) that is separated from a smaller bright cloud (cap) by faint diffuse emission. Based on hardness images and spectra, we identify the bar and cap as a single shocked interstellar cloud. Its morphology strongly resembles the ``voided sphere'' structures seen at late times in Klein et al.'s experimental simulations of cloud-shock interactions, when the crushing of the cloud by shear instabilities is well underway. We infer an interaction time of roughly 3 cloud-crushing timescales, which translates to 2000-4000 years, based on the X-ray temperature, physical size, and estimated expansion of the shocked cloud. This is the first X-ray identified example of a cloud-shock interaction in this advanced phase. Closer to the shock front, the X-ray emission of the compact knot in the eastern part of the BEK region implies a recent interaction with relatively denser gas, some of which lies in front of the remnant. The complex spatial relationship of the X-ray emission of the compact knot to optical [O III] emission suggests that there are multiple cloud interactions occurring along the line of sight.Comment: 22 pages LaTeX with multiple figures, to appear in Ap

Liposomal daunorubicin as treatment for Kaposi’s sarcoma

Anthracycline compounds including daunorubicin are the foundation of many modern chemotherapeutic regimens. However, the side-effects of these compounds can be severe, leading to alopecia, nausea, immune deficiency, and cardiotoxicity. For immunocompromised patients with aggressive Kaposi’s sarcoma (KS), these complications often preclude the completion of appropriate chemotherapeutic regimens. This review focuses on the development and efficacy of liposomal daunorubicin (DaunoXome®; DNX) carriers for the treatment of KS. Encouragingly, DNX demonstrated increased in vivo stability and specificity. As a result, KS patients benefit from higher cumulative chemotherapeutic doses without significant cardiotoxicity. Tumor response to DNX treatment surpasses that of non-encapsulated daunorubicin and is similar to that observed with conventional multi-drug therapies such as ABV (doxorubicin, bleomycin, vincristine). Moreover, some reports indicate the patient quality of life during therapy may improve with DNX treatment. Although the development of DNX represents a significant advance in KS therapy, recent data suggest that additional modification of the liposomal carrier to include pegylation or target specific antibodies may further increase daunorubicin efficacy in the future

Chandra and ASCA X-ray Observations of the Radio Supernova SN1979C IN NGC 4321

We report on the X-ray observation of the radio selected supernova SN1979C carried out with ASCA in 1997 December and serendipitously available from a Chandra Guaranteed Time Observation in 1999 November. The supernova, of type SN II-Linear (SN IIL), was first observed in the optical and occurred in the weakly barred, almost face on spiral galaxy NGC 4321 (M100). The galaxy, a member of the Virgo S cluster, is at a distance of 17.1 Mpc, and contains at least three other supernovae discovered in this century. The useful exposure time was ~25 ks for the Solid-State Imaging Spectrometer (SIS), ~28 ks for the Gas Scintillation Imaging Spectrometer (GIS), and ~2.5 ks for Chandra's Advanced CCD Imaging Spectrometer (ACIS). No point source was detected at the radio position of SN1979C in a 3' diameter half power response circle in the ASCA data. The background and galaxy subtracted SN signal had a 3sigma upper limit to the flux of 6.3x10^-14 ergs/s/cm^-2 in the full ASCA SIS band (0.4-10.0 keV) and a 3sigma upper limit of <3-4x10^-14 erg/s/cm^2 in the 2-10 keV band. In the Chandra data, a source at the position of SN1979C is marginally detected at energies below 2 keV at a flux consistent with the ROSAT HRI detection in 1995. At energies above 2 keV, no source is detected with an upper limit of ~3x10^-14 erg/s/cm^-2. These measurements give the first ever x-ray flux limit of a Type IIL SN above 2 keV which is an important diagnostic of the outgoing shock wave ploughing through the circumstellar medium.Comment: 8 pages, 2 figures, accepted A

Physical Properties of the X-ray Luminous SN 1978K in NGC 1313 from Multiwavelength Observations

We update the light curves from the X-ray, optical, and radio bandpasses which we have assembled over the past decade, and present two observations in the ultraviolet using the Hubble Space Telescope Faint Object Spectrograph. The HRI X-ray light curve is constant within the errors over the entire observation period. This behavior is confirmed in the ASCA GIS data obtained in 1993 and 1995. In the ultraviolet, we detected Ly-alpha, the [Ne IV] 2422/2424 A doublet, the Mg II doublet at 2800 A, and a line at ~3190 A we attribute to He I 3187. Only the Mg II and He I lines are detected at SN1978K's position. The optical light curve is formally constant within the errors, although a slight upward trend may be present. The radio light curve continues its steep decline. The longer time span of our radio observations compared to previous studies shows that SN1978K is in the same class of highly X-ray and radio-luminous supernovae as SN1986J and SN1988Z. The [Ne IV] emission is spatially distant from the location of SN1978K and originates in the pre-shocked matter. The Mg II doublet flux ratio implies the quantity of line optical depth times density of ~10^14 cm^-3 for its emission region. The emission site must lie in the shocked gas.Comment: 32 pages, 13 figs; LaTeX with AASTEXv5; paper accepted, scheduled for AJ, Dec 199