Establishing the potential for using routine data on Incapacity Benefit to assess the local impact of policy initiatives

<i>Background</i>: Incapacity Benefit (IB) is the key contributory benefit for people who are incapable of work because of illness or disability. <i>Methods</i>: The aims were to establish the utility of routinely collected data for local evaluation and to provide a descriptive epidemiology of the IB population in Glasgow and Scotland for the period 2000–05 using data supplied by the Department for Work and Pensions. <i>Results</i>: Glasgow's IB population is large in absolute and relative terms but is now falling, mainly due to a decrease in on flow. Claimants, tend to be older, have a poor work history and suffer from mental health problems. The rate of decline has been greater in Glasgow than Scotland, although the rate of on flow is still higher. <i>Conclusions</i>: Department for Work and Pensions (DWP) data can be used locally to provide important insights into the dynamics of the IB population. However, to be truly useful, more work needs to be undertaken to combine the DWP data with other information

Ion observations from geosynchronous orbit as a proxy for ion cyclotron wave growth during storm times

[1] There is still much to be understood about the processes contributing to relativistic electron enhancements and losses in the radiation belts. Wave particle interactions with both whistler and electromagnetic ion cyclotron (EMIC) waves may precipitate or accelerate these electrons. This study examines the relation between EMIC waves and resulting relativistic electron flux levels after geomagnetic storms. A proxy for enhanced EMIC waves is developed using Los Alamos National Laboratory Magnetospheric Plasma Analyzer plasma data from geosynchronous orbit in conjunction with linear theory. In a statistical study using superposed epoch analysis, it is found that for storms resulting in net relativistic electron losses, there is a greater occurrence of enhanced EMIC waves. This is consistent with the hypothesis that EMIC waves are a primary mechanism for the scattering of relativistic electrons and thus cause losses of such particles from the magnetosphere

Chiral boundary conditions for Quantum Hall systems

A quantum mesoscopic billiard can be viewed as a bounded electronic system due to some external confining potential. Since, in general, we do not have access to the exact expression of this potential, it is usually replaced by a set of boundary conditions. We discuss, in addition to the standard Dirichlet choice, the other possibilities of boundary conditions which might correspond to more complicated physical situations including the effects of many body interactions or of a strong magnetic field. The latter case is examined more in details using a new kind of chiral boundary conditions for which it is shown that in the Quantum Hall regime, bulk and edge characteristics can be described in a unified way.Comment: 16 pages, LaTeX, 2 figures, to be published in the Proceedings of the Minerva workshop on Mesoscopics, Fractals and Neural Networks, Phil. Mag. (1997

Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system

BACKGROUND: Eimeria species are parasitic protozoa that cause coccidiosis, an intestinal disease commonly characterised by malabsorption, diarrhoea and haemorrhage that is particularly important in chickens. Vaccination against chicken coccidiosis is effective using wild-type or attenuated live parasite lines. The development of protocols to express foreign proteins in Eimeria species has opened up the possibility of using Eimeria live vaccines to deliver heterologous antigens and function as multivalent vaccine vectors that could protect chickens against a range of pathogens. RESULTS: In this study, genetic complementation was used to express immunoprotective virus antigens in Eimeria tenella. Infectious bursal disease virus (IBDV) causes Gumboro, an immunosuppressive disease that affects productivity and can interfere with the efficacy of poultry vaccination programmes. Infectious laryngotracheitis virus (ILTV) causes a highly transmissible respiratory disease for which strong cellular immunity and antibody responses are required for effective vaccination. Genes encoding the VP2 protein from a very virulent strain of IBDV (vvVP2) and glycoprotein I from ILTV (gI) were cloned downstream of 5’Et-Actin or 5’Et-TIF promoter regions in plasmids that also contained a mCitrine fluorescent reporter cassette under control of the 5’Et-MIC1 promoter. The plasmids were introduced by nucleofection into E. tenella sporozoites, which were then used to infect chickens. Progeny oocysts were sorted by FACS and passaged several times in vivo until the proportion of fluorescent parasites in each transgenic population reached ~20 % and the number of transgene copies per parasite genome decreased to < 10. All populations were found to transcribe and express the transgene and induced the generation of low titre, transgene-specific antibodies when used to immunise chickens. CONCLUSIONS: E. tenella can express antigens of other poultry pathogens that are successfully recognised by the chicken immune system. Nonetheless, further work has to be done in order to improve the levels of expression for its future use as a multivalent vaccine vector. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-016-1756-2) contains supplementary material, which is available to authorized users

Tuning the effects of Landau-level mixing on anisotropic transport in quantum Hall systems

Electron-electron interactions in half-filled high Landau levels in two-dimensional electron gases in a strong perpendicular magnetic field can lead to states with anisotropic longitudinal resistance. This longitudinal resitance is generally believed to arise from broken rotational invariance, which is indicated by charge density wave (CDW) order in Hartree-Fock calculations. We use the Hartree-Fock approximation to study the influence of externally tuned Landau level mixing on the formation of interaction induced states that break rotational invariance in two-dimensional electron and hole systems. We focus on the situation when there are two non-interacting states in the vicinity of the Fermi level and construct a Landau theory to study coupled charge density wave order that can occur as interactions are tuned and the filling or mixing are varied. We examine in detail a specific example where mixing is tuned externally through Rashba spin-orbit coupling. We calculate the phase diagram and find the possibility of ordering involving coupled striped or triangular charge density waves in the two levels. Our results may be relevant to recent transport experiments on quantum Hall nematics in which Landau-level mixing plays an important role.Comment: 25 pages, 6 figure

Coordinate shift in the semiclassical Boltzmann equation and the anomalous Hall effect

We propose a gauge invariant expression for the side jump associated with scattering between particular Bloch states. Our expression for the side jump follows from the Born series expansion for the scattering T-matrix in powers of the strength of the scattering potential. Given our gauge invariant side jump expression, it is possible to construct a semiclassical Boltzmann theory of the anomalous Hall effect which expresses all previously identified contributions in terms of gauge invariant quantities and does not refer explicitly to off-diagonal terms in the density-matrix response.Comment: 6 pages, 1 fugure. submitted to PR

Correlations in Two-Dimensional Vortex Liquids

We report on a high temperature perturbation expansion study of the superfluid-density spatial correlation function of a Ginzburg-Landau-model superconducting film in a magnetic field. We have derived a closed form which expresses the contribution to the correlation function from each graph of the perturbation theory in terms of the number of Euler paths around appropriate subgraphs. We have enumerated all graphs appearing out to 10-th order in the expansion and have evaluated their contributions to the correlation function. Low temperature correlation functions, obtained using Pad\'{e} approximants, are in good agreement with Monte Carlo simulation results and show that the vortex-liquid becomes strongly correlated at temperatures well above the vortex solidification temperature.Comment: 18 pages (RevTeX 3.0) and 4 figures, available upon request, IUCM93-01

Eigenvalue Separation in Some Random Matrix Models

The eigenvalue density for members of the Gaussian orthogonal and unitary ensembles follows the Wigner semi-circle law. If the Gaussian entries are all shifted by a constant amount c/Sqrt(2N), where N is the size of the matrix, in the large N limit a single eigenvalue will separate from the support of the Wigner semi-circle provided c > 1. In this study, using an asymptotic analysis of the secular equation for the eigenvalue condition, we compare this effect to analogous effects occurring in general variance Wishart matrices and matrices from the shifted mean chiral ensemble. We undertake an analogous comparative study of eigenvalue separation properties when the size of the matrices are fixed and c goes to infinity, and higher rank analogues of this setting. This is done using exact expressions for eigenvalue probability densities in terms of generalized hypergeometric functions, and using the interpretation of the latter as a Green function in the Dyson Brownian motion model. For the shifted mean Gaussian unitary ensemble and its analogues an alternative approach is to use exact expressions for the correlation functions in terms of classical orthogonal polynomials and associated multiple generalizations. By using these exact expressions to compute and plot the eigenvalue density, illustrations of the various eigenvalue separation effects are obtained.Comment: 25 pages, 9 figures include