Immunotherapeutic Biologic Agents to Treat Autoinflammatory Diseases

In recent years, innovative treatment for patients with autoimmune and autoinflammatory diseases has advanced in concert with our increased understanding of molecular and clinical immunology. Deeper understanding of autoimmunity has allowed for the development of cutting-edge biologic drugs for patients with relatively common autoimmune diseases. During this same period, knowledge regarding the molecular bases of autoinflammatory genetic diseases has also greatly expanded. Biologic immunotherapeutic agents developed for autoimmune diseases that primarily target cytokines that are also dysregulated in the uncommon autoinflammatory diseases are the focus of this article. In the following pages, selected genetic autoinflammatory diseases and key immunotherapeutic treatment approaches are addressed. The current understanding of these diseases and mechanisms by which therapeutic agents may benefit patients are reviewed. Indications, risks, and additional considerations for the use of these agents in treatment of autoinflammatory disorders are addressed as well

Investigation of the Magellanic eclipsing binary HV 2241

We present a CCD V light curve of HV 2241, together with some observations in the B band. We analysed our photometric data jointly with previously published radial velocities by means of the Wilson-Devinney code, and derived new values for the physical parameters of this massive eclipsing binary system. We confirm that this system is semi-detached, with the secondary (less massive and less luminous component) filling its Roche-lobe. From our analysis, we estimate the following masses and radii for the components of HV 2241: M1 = 36.2 ± 0.7 M⊙, R1 = 14.9 ± 0.4 R⊙, M2 = 18.4 ± 0.7 M⊙ and R2 = 13.7 ± 0.4 R⊙. We review the spectral classification analysing HST and IUE data and discuss the temperature and the reddening for this star.Facultad de Ciencias Astronómicas y Geofísica

Investigation of the Magellanic eclipsing binary HV 2241

We present a CCD V light curve of HV 2241, together with some observations in the B band. We analysed our photometric data jointly with previously published radial velocities by means of the Wilson-Devinney code, and derived new values for the physical parameters of this massive eclipsing binary system. We confirm that this system is semi-detached, with the secondary (less massive and less luminous component) filling its Roche-lobe. From our analysis, we estimate the following masses and radii for the components of HV 2241: M1 = 36.2 ± 0.7 M⊙, R1 = 14.9 ± 0.4 R⊙, M2 = 18.4 ± 0.7 M⊙ and R2 = 13.7 ± 0.4 R⊙. We review the spectral classification analysing HST and IUE data and discuss the temperature and the reddening for this star.Facultad de Ciencias Astronómicas y Geofísica

The globular cluster system of the low-luminosity elliptical galaxy NGC 1427

Washington photometry is presented for a large number of globular cluster candidates associated with the low-luminosity elliptical galaxy NGC 1427 in the Fornax cluster. The survey is mostly complete to T1 = 23.5 (V ≈ 24.0) and includes an areal coverage of about 216 arcmin2, centered near the galaxy. Most previous studies have failed to detect any evidence of multiple globular cluster populations in this low-luminosity elliptical, in sharp contrast to the bimodal globular cluster systems commonly found in giant ellipticals. The lack of multimodal cluster populations has been used as the basis for suggesting that the formation mechanisms for low-luminosity and giant ellipticals are significantly different. Our metallicity-sensitive C-T1 photometry (the first such study of a low-luminosity elliptical) reveals a definite bimodal cluster population. The red globular cluster population appears strongly centrally concentrated and practically disappears beyond a galactocentric radius of 120″. The mean color of these clusters is similar to that of the inner galaxy halo. Blue globulars, on the other hand, exhibit a shallower spatial distribution. These clusters share a small negative C-T1 color gradient with the galaxy halo, although they are, on average, some 0.3 mag bluer at all galactocentric radii. The overall mean cluster system metallicity is -0.9 ± 0.2. The specific globular cluster frequency SN is 4.5 ± 0.8, if a distance modulus (V0 - Mv) = 31.0 is adopted. Our results demonstrate that nonunimodal globular cluster populations exist in low-luminosity ellipticals, as well as in giant ellipticals, and thus that the formation mechanisms for these galaxies may share some similarities.Facultad de Ciencias Astronómicas y Geofísica

An observational study of delivered and received aggression, gender, and social-psychological adjustment in preschool: Abstract This White Crayon Doesn\u27t Work ...

A semi-structured observational study investigated gender differences in delivered and received relational, physical, verbal, and nonverbal aggression in a young preschool sample (N = 60). Findings revealed that gender differences in subtypes of aggression may be apparent as early as 3 years of age. Specifically, girls were found to deliver and receive more relational aggression than males, whereas boys tended, although not significantly, to deliver and significantly received more physical aggression than females. Relational and physical subtypes of delivered and received aggression were differentially associated with preschoolers\u27 social-psychological adjustment

Investigation of the Magellanic eclipsing binary HV 2241

We present a CCD V light curve of HV 2241, together with some observations in the B band. We analysed our photometric data jointly with previously published radial velocities by means of the Wilson-Devinney code, and derived new values for the physical parameters of this massive eclipsing binary system. We confirm that this system is semi-detached, with the secondary (less massive and less luminous component) filling its Roche-lobe. From our analysis, we estimate the following masses and radii for the components of HV 2241: M1 = 36.2 ± 0.7 M⊙, R1 = 14.9 ± 0.4 R⊙, M2 = 18.4 ± 0.7 M⊙ and R2 = 13.7 ± 0.4 R⊙. We review the spectral classification analysing HST and IUE data and discuss the temperature and the reddening for this star.Facultad de Ciencias Astronómicas y Geofísica

Globular Cluster Systems in Giant Ellipticals: the Mass/Metallicity Relation

Hubble Space Telescope ACS/WFC data in (B,I) are used to investigate the globular cluster populations around 6 gE galaxies ~40 Mpc distant. The total comprises a sample of ~8000 high-probability globular clusters. PSF-convolved King-model profiles are used to measure their individual total magnitudes, colors, and effective radii. The classic bimodal form of the GC color-magnitude distribution shows up unambiguously in all the galaxies, allowing an accurate definition of the mean colors along each of the two sequences as a function of magnitude (the mass/metallicity relation or MMR). The blue, metal-poor cluster sequence shows a clearly defined but nonlinear MMR, changing smoothly from a near-vertical sequence at low luminosity to an increasingly redward slope at higher luminosity, while the red, metal-rich sequence is nearly vertical at all luminosities. All the observed features of the present data agree with the interpretation that the MMR is created primarily by GC self-enrichment, along the lines of the quantitative model of Bailin and Harris (2009): The "threshold" mass at which this effect should become noticeable is near 1 million Solar masses, which is closely consistent with the transition region that is seen in the data. Correlation of the median half-light radii of the GCs with other parameters shows that the metal-poor clusters are consistently 17% larger than those of the metal-rich clusters, at all galactocentric distances and luminosities. At the same time, cluster size scales with halo location as r_h ~ R_gc^0.11, indicating that both metallicity and the external tidal environment play roles in determining the scale size of a given cluster. Lastly, both the red and blue GC components show metallicity gradients with galactocentric distance, following Z ~ R_gc^-0.1.Comment: In press for Astrophysical Journal. Complete preprint with higher quality figures is available at http://physwww.mcmaster.ca/%7Eharris/Publications.htm

Early parenting and children\u27s relational and physical aggression in the preschool and home contexts

This study investigated early parent- child relationships and how children\u27s use of relational and physical aggression varies with aspects of those relationships during the preschool years. Specifically, parenting styles, parents\u27 use of psychological control, and parents\u27 report of their children\u27s reunion behaviors were assessed. Analyses revealed significant associations between children\u27s use of both relational and physical aggression and parents\u27 reports of their own and their partner\u27s parenting style, psychological control behaviors, and indicators of the attachment relationship. The results highlight the importance of investigating both mothers\u27 and fathers\u27 parenting and the sex of the child in studies of potential links between parenting behaviors and young children’s relational and physical aggression. Findings were considered in the context of each perspective and suggestions for future research and implications for intervention and prevention are discussed

The globular cluster system of the low-luminosity elliptical galaxy NGC 1427

Washington photometry is presented for a large number of globular cluster candidates associated with the low-luminosity elliptical galaxy NGC 1427 in the Fornax cluster. The survey is mostly complete to T1 = 23.5 (V ≈ 24.0) and includes an areal coverage of about 216 arcmin2, centered near the galaxy. Most previous studies have failed to detect any evidence of multiple globular cluster populations in this low-luminosity elliptical, in sharp contrast to the bimodal globular cluster systems commonly found in giant ellipticals. The lack of multimodal cluster populations has been used as the basis for suggesting that the formation mechanisms for low-luminosity and giant ellipticals are significantly different. Our metallicity-sensitive C-T1 photometry (the first such study of a low-luminosity elliptical) reveals a definite bimodal cluster population. The red globular cluster population appears strongly centrally concentrated and practically disappears beyond a galactocentric radius of 120″. The mean color of these clusters is similar to that of the inner galaxy halo. Blue globulars, on the other hand, exhibit a shallower spatial distribution. These clusters share a small negative C-T1 color gradient with the galaxy halo, although they are, on average, some 0.3 mag bluer at all galactocentric radii. The overall mean cluster system metallicity is -0.9 ± 0.2. The specific globular cluster frequency SN is 4.5 ± 0.8, if a distance modulus (V0 - Mv) = 31.0 is adopted. Our results demonstrate that nonunimodal globular cluster populations exist in low-luminosity ellipticals, as well as in giant ellipticals, and thus that the formation mechanisms for these galaxies may share some similarities.Facultad de Ciencias Astronómicas y Geofísica