167 research outputs found
Results of posterior lamellar femto-keratoplasty using two different lasers
Purpose. To evaluate the results of treatment of patients with pseudophakic bullous keratopathy (PBK) by the method of posterior lamellar femto-keratoplasty with ultrathin graft (FS-DSEK) harvested using two different lasers.Material and methods. The results of surgical treatment of 82 patients (82 eyes) underwent posterior lamellar femto-keratoplasty for PBK were analyzed. In the 1st group included 43 patients (43 eyes) with PBK underwent FS-DSEK using FS laser Femto-Visum (Optosystems, Russia). In the 2nd group included 39 patients (39 eyes) with PBK underwent FS-DSEK using LDV Z8 (Ziemer, Switzerland). Observation period was 1 year. Before and after surgery following indicators were evaluated: uncorrected visual acuity (UCVA), best spectacle corrected visual acuity (BSCVA), postoperative astigmatism, central corneal thickness (CCT), graft thickness, center-periphery (C:P) ratio, endothelial cell density (ECD), endothelial cell (EC) loss, optical density .Results. Transparent engraftment at 1-year observation period was observed in 88% of cases. In the 1st group UCVA=0.22Β±0.11, BSCVA=0.32Β±0.12, in the 2nd group UCVA=0.18Β±0.08, BSCVA=0.29Β±0.1 (p>0.05). The maximum BSCVA in both groups was 0.6. Postoperative astigmatism was comparative in 2nd groups β 1.43Β±1.1 and 1.38Β±1.0 D, respectively (p>0.05). In the 1st group, CCT=549Β±31, graft thickness in the central zone β 83Β±12, C:P ratio β 0.92Β±0.05; in the 2nd group CCT=546Β±28, graft thickness β 80Β±10, C:P ratio β 0.94Β±0.06 (p>0.05). In the 1st group ECD β 1326Β±282, EC loss β 55Β±6%; ECD in the 2nd β 850Β±230, EC loss β 70Β±7% (p<0.05). According to the results of densitometry, optical density of the posterior layers of the cornea and Β«donorβrecipientΒ» interface zone was higher in the 2nd group, both in the central and in the paracentral zones: in the 1st group in the posterior layers of the stroma β 16.4Β±1.2 (0β2 mm) and 15.8Β±1.0 (2β6 mm), in the interface zone β 14.5Β±0.9 (0β2) and 13.9Β±0.8 (2β6), in the 2nd group in the posterior layers β 18.3Β±1.3 (0β2 mm) and 17.9Β±1.1 (2β6 mm), and in the interface zone β 17.3Β±1.2 (0β2 mm) and 17.0Β±1.0 (2β6 mm, p<0.05).Conclusions. FS-DSEK showed high efficiency for treating patients with PBK. Functional results were comparative in 2nd groups. Statistical analysis showed highest safety of transplanted endothelium in the 1st group at 1-year observation period
Clinical and morphological features of salmonellosis in cows and calves affected by heat stress
Exposure to abnormally high temperatures in the Middle Urals has ledtochronic heat stress in cattle. Despitethe measures taken toprotect thedairy herdfrom overheating (fans, irrigationwith coolwater, livestocksunshades), the heatstressunderminedtheimmunityofanimals, thus, leadingtoan excessiverisein Salmonella population in the gastrointestinal tract, increasedin test in alpermeability, and could also bethecause of increasedvirulence of such serotypes asΒ β Salmonella choleraesuis, that are not typical for cattle. The simultaneous presenceof twopathogensof Salmonella entericasubsp. entericaspecies: i.e.Β Salmonella enteritidis and Salmonella choleraesuisΒ β causeda number of clinical and morphological changesin adultcows. In cows, the infection manifested itself by persistent diarrhea with mucus, reduced milkproduction and intoxication. In calves, the disease was accompanied by septic signs, severein toxication, hyperthermia (40.5β41.0Β Β°C), severed ehydration (morethan 7%) and death. Histopathological examination of bovineparenchymal organs revealed changes typical for salmonellos is pathological process: specific salmonella granulomas were foundin parenchymalorgans (liver, spleen). Some pathological processestypical for sepsiswere foundin other parenchymalorgans (kidneys, heart). The nature of pathological changes in dicates that there is as epticprocess that spreads both hematogenically and lymphogenically, and the structure of granulomas most likely indicates that such apathogen as Salmonelacholeraesuis circulates in cattle
Impact of transfusion of blood components on the recipient immune system
Transfusions of blood provide essential therapeutic measures in a number of pathological conditions. However, when carrying out blood component therapy, it is important to consider probability of post-transfusion complications. Most of them are immune-mediated side effects. The unfavorable consequences of blood transfusions can manifest at long-range time periods, and pathogenesis of these phenomena may be associated not only with the presence of alloantibodies. They may be caused by alloimmunization to HLA antigens, leukocyte factors, including cytokines, products of leukocyte degranulation, as well as storage-related erythrocyte damage (Β«storage lesionΒ»), immunomodulatory properties of extracellular vesicles or microparticles derived from blood components, and other factors. Despite significant number of publications on this issue, a lot of unresolved issues still remain, concerning transfusion-related effects of blood components on the immune system of recipients. The review article provides the results of current studies in this area. We present and discuss the results of current studies and the features of transfusion-mediated immunomodulation (TRIM) revealed over recent years, when transfusing different blood components. The role of plasma factors, microparticles, platelets and erythrocytes, HLA sensitization and microchimerism in the development of TRIM is highlighted, the data on occurrence and clinical features of TRIM in perioperative period are presented. A separate section of the review provides information about recent clinical studies, devoted to the issues of TRIM in different clinical cohorts, including newborns, patients with malignant neoplasms, immunocompromised patients after heart and vascular surgery. The data on TRIM incidence in the patients with exhausted immune system due to previous disease or treatment, severe comorbidity, extensive surgical thoracic/abdominal intervention and artificial circulation are also in scope. As based on the studies performed, the role of distinct measures, e.g., washing of erythrocyte concentrates, leukodepletion, and gamma irradiation are discussed in view of potential TRIM prevention. The results of published research do not allow us to draw definite conclusions about the effects of blood component transfusion on the immune system of recipients with respect to differences between the studied groups of patients, characteristics of the studied disorders and clinical situations, diversity of hemocomponents, as well as varying standards of transfusion therapy adopted in different countries. However, the systematic literature review may provide some guidance in transfusion-mediated immune modulation
The cellular location of proteolytic enzymes of Bacillus intermedius
The activities of proteinases in the culture fluid and cellular fractions of Bacillus intermedius 3-19 grown under various conditions were studied. Thiol-dependent serine proteinase was the prevalent enzyme in the total pool of extracellular proteinases (70%); its catalytically active form was also detected in the cell membrane and, during active enzyme production, in the cell wall. Another enzyme, glutamyl endopeptidase (10% of the total pool), was detected in the cell membrane; it was also found in the cell wall and cytoplasm during active enzyme secretion into the growth medium. The production of these enzymes was maximal on medium containing inorganic phosphate and gelatin and decreased 2- to 4-fold on medium with glucose and lactate. The level of activity of extracellular enzymes correlated with that of corresponding membrane-bound proteins. The addition of CoCl2 (2 mM) into the medium caused an essential increase in extracellular glutamyl endopeptidase activity and promoted the release of the membrane-bound enzyme into the culture fluid. Proteolytic activity towards casein was also detected in the cytoplasm. The proteinases localized in the cytoplasm were shown to differ in their properties from those secreted. Β© 2000 MAIK "Nauka/Interperiodica"
Influence of human peripheral blood samples preprocessing on the quality of Hi-C libraries
The genome-wide variant of the chromatin conformation capture technique (Hi-C) is a powerful tool for revealing patterns of genome spatial organization, as well as for understanding the effects of their disturbance on disease development. In addition, Hi-C can be used to detect chromosomal rearrangements, including balanced translocations and inversions. The use of the Hi-C method for the detection of chromosomal rearrangements is becoming more widespread. Modern high-throughput methods of genome analysis can effectively reveal point mutations and unbalanced chromosomal rearrangements. However, their sensitivity for determining translocations and inversions remains rather low. The storage of whole blood samples can affect the amount and integrity of genomic DNA, and it can distort the results of subsequent analyses if the storage was not under proper conditions. The Hi-C method is extremely demanding on the input material. The necessary condition for successfully applying Hi-C and obtaining high-quality data is the preservation of the spatial chromatin organization within the nucleus. The purpose of this study was to determine the optimal storage conditions of blood samples for subsequent Hi-C analysis. We selected 10 different conditions for blood storage and sample processing. For each condition, we prepared and sequenced Hi-C libraries. The quality of the obtained data was compared. As a result of the work, we formulated the requirements for the storage and processing of samples to obtain high-quality Hi-C data. We have established the minimum volume of blood sufficient for conducting Hi-C analysis. In addition, we have identified the most suitable methods for isolation of peripheral blood mononuclear cells and their long-term storage. The main requirement we have formulated is not to freeze whole blood
SNP-Based Chromosomal Microarray Analysis for Detecting DNA Copy Number Variations in Fetuses with a Thickened Nuchal Fold
The aim of the study was to assess the diagnostic potential of SNP-based chromosomal microarray analysis for detecting pathogenic copies number variations (CNVs) in fetuses with a normal karyotype, in which an increase in the nuchal translucence of >2.5 mm was detected by ultrasound at a gestational age of 11 weeks to 13 weeks 6 days. MATERIALS AND METHODS: The study included 225 pregnant women who underwent invasive prenatal diagnostic procedures following the detection of an isolated thickening of the fetal nuchal fold. The fetal material obtained was examined using a cytogenetic test; if a normal karyotype was confirmed, chromosomal microarray analysis was performed as a second-line test. RESULTS: Pathogenic CNVs were detected in 22 of 225 fetuses (9.8%) with a normal karyotype. Of these 22 fetuses, pathogenic CNVs not classified as syndromes were detected in 14 cases (63.6%), and those previously described as syndromes β in 8 cases (36.4%). In 9 fetuses (41%), CNVs in two non-homologous chromosomes were determined; these findings indicated a high likelihood of carrying balanced translocations in the parents. Indeed, when analyzing the parentβs karyotype, in 8 out of 9 couples, balanced translocations were found in one of the parents. CONCLUSION: Using chromosomal microarray analysis in fetuses with a thickened nuchal fold makes it possible to increase the ability to detect chromosomal imbalances, including those caused by pathological meiotic segregation of parental reciprocal translocation
Π’Π΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΈ ΡΠ΅Ρ Π½ΠΈΠΊΠ° Π΄Π»Ρ ΡΠ±ΠΎΡΠΊΠΈ ΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠΈΡΠΎΠ²ΠΊΠΈ Π·Π΅ΡΠ½Π° Π² ΡΠ΅Π»Π΅ΠΊΡΠΈΠΈ ΠΈ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΌ ΡΠ΅ΠΌΠ΅Π½ΠΎΠ²ΠΎΠ΄ΡΡΠ²Π΅
Trial plots are necessary for breed new varieties and renewal of the used ones on a scientific basis. Efficiency and an intensification of selection breeding and seed production processes substantially depends on technique of selection establishments. Creation of new generation of machines should be carried out according to the reached technological level and constructive decisions directed on resource-saving and the fullest accounting of agrobiological features of objects of machine influence, especially grain crops. In the course of grain harvest and transportation when selection works the bags complicated mechanization of process of delivery of grain from the harvester to a point of processing was widely applied so far. The authors suggested to substitute soft bags for rigid containers. Dimensions of transportation containers should be not exceeding a cross internal dimension of vehicles or multiply to take place in this dimension. The container dimension in the plan is a square with side not less than 1120 mm and high not less than 565 mm. A bottom of containers for grain drying is holed, a grain layer is no more than 300 mm. Due to containers advantages technological capabilities are possible: transportations of grain from the harvest to the point of grain processing, grain drying in containers, a mechanized unloading. Use of such containers will allow to lower labor and farm costs and by 5 times, to double filling of warehouses, completely to liquidate manual works at loading and unloading operations, to reduce wasted time by 1.5-2 times.ΠΡΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ
ΠΈ Π²ΠΎΠ·ΠΎΠ±Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
ΡΠΎΡΡΠΎΠ² Π·Π΅ΡΠ½ΠΎΠ²ΡΡ
ΠΊΡΠ»ΡΡΡΡ Π½Π° Π½Π°ΡΡΠ½ΠΎΠΉ ΠΎΡΠ½ΠΎΠ²Π΅ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ Π±Π΅Π· ΠΏΠΎΠ»Π΅Π²ΠΎΠΉ ΡΡΠ°Π΄ΠΈΠΈ ΠΈΡ
ΠΎΡΡΠ°Π±ΠΎΡΠΊΠΈ Π½Π° ΡΠ΅Π»Π΅ΠΊΡΠΈΠΎΠ½Π½ΠΎ-ΠΎΠΏΡΡΠ½ΡΡ
Π΄Π΅Π»ΡΠ½ΠΊΠ°Ρ
. ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΡΠ΅Π»Π΅ΠΊΡΠΈΠΎΠ½Π½ΠΎ-ΡΠ΅ΠΌΠ΅Π½ΠΎΠ²ΠΎΠ΄ΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΠΎΡΠ½Π°ΡΠ΅Π½ΠΈΡ ΡΠ΅Π»Π΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΡΡΠ΅Π΄ΡΡΠ²Π°ΠΌΠΈ ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ. Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΡ ΠΌΠ°ΡΠΈΠ½ Π΄ΠΎΠ»ΠΆΠ½ΠΎ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΡΡΡΡ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΡΠΌ ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΡΠΎΠ²Π½Π΅ΠΌ ΠΈ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡΠΌΠΈ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠΌΠΈ Π½Π° ΡΠ΅ΡΡΡΡΠΎΡΠ±Π΅ΡΠ΅ΠΆΠ΅Π½ΠΈΠ΅ ΠΈ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠΎΠ»Π½ΡΠΉ ΡΡΠ΅Ρ Π°Π³ΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² ΠΌΠ°ΡΠΈΠ½Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π·Π΅ΡΠ½ΠΎΠ²ΡΡ
ΠΊΡΠ»ΡΡΡΡ. ΠΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠ±ΠΎΡΠΊΠΈ ΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠΈΡΠΎΠ²ΠΊΠΈ Π·Π΅ΡΠ½Π° ΠΏΡΠΈ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ ΡΠ΅Π»Π΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ°Π±ΠΎΡ Π΄ΠΎ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»Π°ΡΡ ΠΌΠ΅ΡΠΎΡΠ½Π°Ρ ΡΠ°ΡΠ°, ΡΡΠΎ ΡΡΠ»ΠΎΠΆΠ½ΡΠ»ΠΎ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·Π°ΡΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ Π·Π΅ΡΠ½Π° ΠΎΡ ΠΊΠΎΠΌΠ±Π°ΠΉΠ½Π° Π½Π° ΠΏΡΠ½ΠΊΡ ΠΏΠ΅ΡΠ΅ΡΠ°Π±ΠΎΡΠΊΠΈ. ΠΡΠ΅Π΄Π»ΠΎΠΆΠΈΠ»ΠΈ Π·Π°ΠΌΠ΅Π½ΠΈΡΡ ΠΌΠ΅ΡΠΎΡΠ½ΡΡ ΠΌΡΠ³ΠΊΡΡ ΡΠ°ΡΡ Π½Π° ΠΆΠ΅ΡΡΠΊΡΡ Π² Π²ΠΈΠ΄Π΅ ΠΊΠΎΠ½ΡΠ΅ΠΉΠ½Π΅ΡΠ°. Π£ΡΡΠ°Π½ΠΎΠ²ΠΈΠ»ΠΈ, ΡΡΠΎ ΠΊΠΎΠ½ΡΠ΅ΠΉΠ½Π΅ΡΡ, ΠΏΡΠ΅Π΄Π½Π°Π·Π½Π°ΡΠ΅Π½Π½ΡΠ΅ Π΄Π»Ρ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠΈΡΠΎΠ²ΠΊΠΈ, Π΄ΠΎΠ»ΠΆΠ½Ρ ΠΈΠΌΠ΅ΡΡ Π³Π°Π±Π°ΡΠΈΡΡ, Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°ΡΡΠΈΠ΅ ΠΏΠΎΠΏΠ΅ΡΠ΅ΡΠ½ΡΠΉ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΠΉ Π³Π°Π±Π°ΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΈΠ»ΠΈ ΠΊΡΠ°ΡΠ½ΠΎ ΡΠ°Π·ΠΌΠ΅ΡΠ°ΡΡΡΡ Π² ΡΡΠΎΠΌ Π³Π°Π±Π°ΡΠΈΡΠ΅. ΠΡΠΌΠ΅ΡΠΈΠ»ΠΈ, ΡΡΠΎ Π³Π°Π±Π°ΡΠΈΡ ΠΊΠΎΠ½ΡΠ΅ΠΉΠ½Π΅ΡΠ° Π² ΠΏΠ»Π°Π½Π΅ Π΄ΠΎΠ»ΠΆΠ΅Π½ Π±ΡΡΡ ΠΊΠ²Π°Π΄ΡΠ°ΡΠΎΠΌ ΡΠΎ ΡΡΠΎΡΠΎΠ½ΠΎΠΉ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 1120 ΠΌΠΌ ΠΈ Π²ΡΡΠΎΡΠΎΠΉ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 565 ΠΌΠΌ. ΠΠΎΠ½ΡΠ΅ΠΉΠ½Π΅ΡΡ Π΄Π»Ρ ΡΡΡΠΊΠΈ Π·Π΅ΡΠ½Π° Π΄ΠΎΠ»ΠΆΠ½Ρ ΠΈΠΌΠ΅ΡΡ ΠΏΠ΅ΡΡΠΎΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ Π΄Π½ΠΎ, ΡΠ»ΠΎΠΉ Π·Π΅ΡΠ½Π° - Π½Π΅ Π±ΠΎΠ»Π΅Π΅ 300 ΠΌΠΌ. ΠΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ»ΠΈ, ΡΡΠΎ Π΄ΠΎΡΡΠΎΠΈΠ½ΡΡΠ²Π° ΠΊΠΎΠ½ΡΠ΅ΠΉΠ½Π΅ΡΠΎΠ² ΠΏΡΠΎΡΠ²Π»ΡΡΡΡΡ Π² ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΡ
: ΡΡΠ°Π½ΡΠΏΠΎΡΡΠΈΡΠΎΠ²ΠΊΠΈ Π·Π΅ΡΠ½Π° ΠΎΡ ΠΊΠΎΠΌΠ±Π°ΠΉΠ½Π° Π΄ΠΎ ΠΏΡΠ½ΠΊΡΠ° ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΈ Π·Π΅ΡΠ½Π°, ΡΡΡΠΊΠΈ Π·Π΅ΡΠ½Π° Π² ΠΊΠΎΠ½ΡΠ΅ΠΉΠ½Π΅ΡΠ°Ρ
, ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π²ΡΠ³ΡΡΠ·ΠΊΠΈ. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠ°ΠΊΠΈΡ
ΠΊΠΎΠ½ΡΠ΅ΠΉΠ½Π΅ΡΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ Π² 5 ΡΠ°Π· ΡΠ½ΠΈΠ·ΠΈΡΡ Π·Π°ΡΡΠ°ΡΡ ΡΡΡΠ΄Π° ΠΈ ΡΡΠ΅Π΄ΡΡΠ², Π²Π΄Π²ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠΈΡΡ Π·Π°ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΡΠΊΠ»Π°Π΄ΠΎΠ², ΠΏΠΎΠ»Π½ΠΎΡΡΡΡ Π»ΠΈΠΊΠ²ΠΈΠ΄ΠΈΡΠΎΠ²Π°ΡΡ ΡΡΡΠ½ΠΎΠΉ ΡΡΡΠ΄ Π½Π° ΠΏΠΎΠ³ΡΡΠ·ΠΎΡΠ½ΠΎ-ΡΠ°Π·Π³ΡΡΠ·ΠΎΡΠ½ΡΡ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΡΡ
, ΡΠΎΠΊΡΠ°ΡΠΈΡΡ ΠΏΡΠΎΡΡΠΎΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² Π² 1,5-2 ΡΠ°Π·Π°
ΠΠ‘ΠΠ«Π’ΠΠΠΠ― Π‘ΠΠ‘Π’ΠΠΠ« ΠΠΠΠΠ’ΠΠ ΠΠΠΠ Π‘ΠΠΠΠΠ«Π₯ ΠΠ£ΠΠΠΠΠ
Swap bodies using at agricultural freights is very popular now. Thus the number of vehicles is reduced, operational costs are cut. Efficiency of swap bodies application increases at introduction of transport monitoring system for the purpose of the centralized remote supervision for its movement control. Swap bodies monitoring system was tested, its working ability influence on efficiency of transport service were studied. The block of data acquisition and transfer for swap bodies monitoring system was worked out and tested. Due to indicator of a body filling operability the sensor of level of bulks was checked. The speed of indicator operation when body filling makes 5-10 seconds. Thus filling of a swap body is displayed on the monitor in control office. Location of a swap body display on the monitor in control office was defined by means of imposing of the pictogram on a district map with the indication of coordinates. The device for determination of duration of autonomous work of system works within 2 days, time of a battery charging made 3 h. The device for the swap bodies monitoring system carries out functions in full, providing remote supervision over work of system.ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠΌΠ΅Π½Π½ΡΡ
ΠΊΡΠ·ΠΎΠ²ΠΎΠ² ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠΈΡΠΎΠ²ΠΊΠ΅ ΡΠ΅Π»ΡΡΠΊΠΎΡ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅Π½Π½ΡΡ
Π³ΡΡΠ·ΠΎΠ² ΠΏΠΎΠ»ΡΡΠΈΠ»ΠΎ Π±ΠΎΠ»ΡΡΠΎΠ΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅. ΠΡΠΈ ΡΡΠΎΠΌ ΡΠΎΠΊΡΠ°ΡΠ°Π΅ΡΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ², ΡΠ½ΠΈΠΆΠ°ΡΡΡΡ ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ°ΡΡ
ΠΎΠ΄Ρ. ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΌΠ΅Π½Π½ΡΡ
ΠΊΡΠ·ΠΎΠ²ΠΎΠ² Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π΅Ρ ΠΏΡΠΈ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΠΈ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° Ρ ΡΠ΅Π»ΡΡ ΡΠ΅Π½ΡΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄ΠΈΡΡΠ°Π½ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π΅Π³ΠΎ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ. ΠΡΠΎΠ²Π΅Π»ΠΈ ΠΈΡΠΏΡΡΠ°Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠΌΠ΅Π½Π½ΡΡ
ΠΊΡΠ·ΠΎΠ²ΠΎΠ², ΠΈΠ·ΡΡΠΈΠ»ΠΈ Π΅Π΅ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΈ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π»ΠΈ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½ΠΈΠ»ΠΈ Π½Π° ΠΈΡΠΏΡΡΠ°Π½ΠΈΡΡ
Π±Π»ΠΎΠΊ ΡΠ±ΠΎΡΠ° ΠΈ ΠΏΠ΅ΡΠ΅Π΄Π°ΡΠΈ Π΄Π°Π½Π½ΡΡ
ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠΌΠ΅Π½Π½ΡΡ
ΠΊΡΠ·ΠΎΠ²ΠΎΠ². ΠΡΠΎΠ²Π΅ΡΠΈΠ»ΠΈ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ Π΄Π°ΡΡΠΈΠΊΠ° ΡΡΠΎΠ²Π½Ρ ΡΡΠΏΡΡΠΈΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠ° Π·Π°ΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΊΡΠ·ΠΎΠ²Π°. ΠΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ ΡΠΊΠΎΡΠΎΡΡΡ ΡΡΠ°Π±Π°ΡΡΠ²Π°Π½ΠΈΡ ΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠ° ΠΏΡΠΈ Π·Π°ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ ΠΊΡΠ·ΠΎΠ²Π° ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 5-10 ΡΠ΅ΠΊΡΠ½Π΄. ΠΡΠΈ ΡΡΠΎΠΌ Π·Π°ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΡΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΡΠ·ΠΎΠ²Π° ΠΎΡΠΎΠ±ΡΠ°ΠΆΠ°Π΅ΡΡΡ Π½Π° ΠΌΠΎΠ½ΠΈΡΠΎΡΠ΅ Π΄ΠΈΡΠΏΠ΅ΡΡΠ΅ΡΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ½ΠΊΡΠ°. ΠΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ»ΠΈ ΠΌΠ΅ΡΡΠΎΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ ΡΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΡΠ·ΠΎΠ²Π° ΠΏΡΡΠ΅ΠΌ ΠΎΡΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΡ Π½Π° ΠΌΠΎΠ½ΠΈΡΠΎΡΠ΅ Π΄ΠΈΡΠΏΠ΅ΡΡΠ΅ΡΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ½ΠΊΡΠ° ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ Π½Π°Π»ΠΎΠΆΠ΅Π½ΠΈΡ ΠΏΠΈΠΊΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π½Π° ΠΊΠ°ΡΡΡ ΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ Ρ ΡΠΊΠ°Π·Π°Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½Π°Ρ. Π£ΡΡΠ°Π½ΠΎΠ²ΠΈΠ»ΠΈ, ΡΡΠΎ ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π°Π²ΡΠΎΠ½ΠΎΠΌΠ½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ°Π±ΠΎΡΠ°Π΅Ρ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 2 ΡΡΡΠΎΠΊ, Π²ΡΠ΅ΠΌΡ Π·Π°ΡΡΠ΄ΠΊΠΈ Π°ΠΊΠΊΡΠΌΡΠ»ΡΡΠΎΡΠ° ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 3 Ρ. ΠΡΠΌΠ΅ΡΠΈΠ»ΠΈ, ΡΡΠΎ ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠΌΠ΅Π½Π½ΡΡ
ΠΊΡΠ·ΠΎΠ²ΠΎΠ² Π²ΡΠΏΠΎΠ»Π½ΡΠ΅Ρ ΡΡΠ½ΠΊΡΠΈΠΈ Π² ΠΏΠΎΠ»Π½ΠΎΠΌ ΠΎΠ±ΡΠ΅ΠΌΠ΅, ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Ρ Π΄ΠΈΡΡΠ°Π½ΡΠΈΠΎΠ½Π½ΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π·Π° ΡΠ°Π±ΠΎΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ
ΠΠ ΠΠ€ΠΠΠΠΠ’ΠΠΠ ΠΠΠ‘ΠΠΠΠΠΠ ΠΠ¦ΠΠΠΠΠΠ ΠΠΠΠΠΠΠΠ¬Π¦ΠΠΠΠΠ Π£ ΠΠΠΠ¬ΠΠ«Π₯ ΠΠΠ€Π€Π£ΠΠΠ«Π Π’ΠΠΠ‘ΠΠ§ΠΠ‘ΠΠΠ ΠΠΠΠΠ
In recent years, the surgical treatment of DTG includes extirpation of the thyroid gland that can lead to the development of postoperative hypocalcemia, which causes of development are under study. Up to now, there are no clear recommendations for prophylaxis of postoperative hypocalcemia. In this connection, it is actually to carry out additional research to explore the methods of prophylaxis of postoperative hypocalcemia. The study involved 57 patients with diffuse toxic goiter, who had extirpation of the thyroid gland in period from 2010 until 2015. According to results of the performed study, it has been shown that prophylactic administration of preparations of calcium and vitamin D reduces the risk of postoperative hypocalcemia for patients with vitamin D deficiency.Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ ΠΏΡΠΈ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π΄ΠΈΡΡΡΠ·Π½ΠΎΠ³ΠΎ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π·ΠΎΠ±Π° Π²ΡΠΏΠΎΠ»Π½ΡΡΡ ΡΠΊΡΡΠΈΡΠΏΠ°ΡΠΈΡ ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ ΠΏΡΠΈΠ²Π΅ΡΡΠΈ ΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΠ°Π»ΡΡΠΈΠ΅ΠΌΠΈΠΈ, ΠΏΡΠΈΡΠΈΠ½Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΊΠΎΡΠΎΡΠΎΠΉ Π½Π° ΡΡΠ°Π΄ΠΈΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ. ΠΠΎ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΠΏΠΎ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΠ°Π»ΡΡΠΈΠ΅ΠΌΠΈΠΈ Π½Π΅Ρ. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΠ°Π»ΡΡΠΈΠ΅ΠΌΠΈΠΈ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 57 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄ΠΈΡΡΡΠ·Π½ΡΠΌ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π·ΠΎΠ±ΠΎΠΌ, ΠΊΠΎΡΠΎΡΡΠΌ Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ Ρ 2010 ΠΏΠΎ2015 Π³. Π±ΡΠ»Π° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° ΡΠΊΡΡΠΈΡΠΏΠ°ΡΠΈΡ ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ, ΠΈΠΌΠ΅ΡΡΠΈΠΌ Π΄Π΅ΡΠΈΡΠΈΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D, ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠΈΠ΅ΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΊΠ°Π»ΡΡΠΈΡ ΠΈ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D ΡΠΌΠ΅Π½ΡΡΠ°Π» ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΠ°Π»ΡΡΠΈΠ΅ΠΌΠΈΠΈ
The segmentation cycle assisted reproductive technologies as a tool to improve the effectiveness of overcoming infertility
Purpose. Evaluate the efficiency of IVFICSI in dependency of the patiencesβ age, ovarian reserve and their response to the ovulation stimulation. Materials and methods. Analyzed 726 cycles IVF ICSI and 358 cycles of unfrozen embryo transfer with a patients, undergoing infertility treatment in years 2017-2018. Analysis concerned age of patients, quantity of antral follicle and oocyte-cumulus complexes, evaluated mature oocytes only, quantity and quality of embryos on the third day, fifth day and at the moment of transferring, quantity of embryos, undergone freezing and biopsy, as well as quantity of progressing and regressing pregnancies. Results. Depending on the patientβs response to the stimulation, the efficiency indicators of IVF ICSI varied. For patients older 39 years, the factor risk of cancelling the IVF ICSI program, due to absence of embryo to the 3-5 days of cultivation, was the availability of less than seven antral follicles to the day of protocol start. With a small amount of genetic material, non-selective method is the risk factor, announcing the low efficiency of IVF ICSI cycle up to 21% clinical pregnancy rate. Segmentation of a cycle, for holding cryo transplantation with a result of pre implantable genetic aneuplodia testing (PGT-A), increased the efficiency of program from 33% up to 50% for the high cryo tolerance embryo transfer. Conclusion. Shown, that the contol on the embiyological stage of IVFICSI and the ability of choosing the high-quality embryo for a transfer, reliably increased the percentage of successful IVF ICSI cycles by the frequency of clinical pregnancies from 21% up to 34% (p<0,05) among women aged 35-36 years, with a sub-optimal response to the stimulation. The holding of PGT-A for the selection of embryos in cycles of cryo transfer, was forming the IVF ICSI cycle efficiency uptrend among women aged over 36 years.Π¦Π΅Π»Ρ. ΠΡΠ΅Π½ΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»ΠΎΠ² ΠΠΠ ΠΠΠ‘Π Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ, ΠΎΠ²Π°ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π·Π΅ΡΠ²Π° ΠΈ ΠΈΡ
ΠΎΡΠ²Π΅ΡΠ° Π½Π° ΡΡΠΈΠΌΡΠ»ΡΡΠΈΡ ΠΎΠ²ΡΠ»ΡΡΠΈΠΈ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· 726 ΡΠΈΠΊΠ»ΠΎΠ² ΠΠΠ ΠΠΠ‘Π ΠΈ 358 ΡΠΈΠΊΠ»ΠΎΠ² ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ° ΡΠ°Π·ΠΌΠΎΡΠΎΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠΌΠ±ΡΠΈΠΎΠ½Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ, ΠΏΡΠΎΡ
ΠΎΠ΄ΠΈΠ²ΡΠΈΡ
Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π±Π΅ΡΠΏΠ»ΠΎΠ΄ΠΈΡ Π² 2017-2018 Π³ΠΎΠ΄Π°Ρ
. ΠΠ½Π°Π»ΠΈΠ· ΠΊΠ°ΡΠ°Π»ΡΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π°Π½ΡΡΠ°Π»ΡΠ½ΡΡ
ΡΠΎΠ»Π»ΠΈΠΊΡΠ»ΠΎΠ² ΠΈ ΠΎΠΎΡΠΈΡ-ΠΊΡΠΌΡΠ»ΡΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ², ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈΡΡ Π·ΡΠ΅Π»ΡΠ΅ ΠΎΠΎΡΠΈΡΡ. ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΈ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΡΠΌΠ±ΡΠΈΠΎΠ½ΠΎΠ² Π½Π° 3 ΡΡΡΠΊΠΈ, 5 ΡΡΡΠΊΠΈ ΠΈ Π½Π° ΠΌΠΎΠΌΠ΅Π½Ρ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ°, ΡΠΈΡΠ»ΠΎ ΡΠΌΠ±ΡΠΈΠΎΠ½ΠΎΠ², ΠΏΠΎΠ΄Π²Π΅ΡΠ³ΡΠΈΡ
ΡΡ Π·Π°ΠΌΠΎΡΠΎΠ·ΠΊΠ΅ ΠΈ Π±ΠΈΠΎΠΏΡΠΈΠΈ. ΠΡΠΈΡΠ΅ΡΠΈΡΠΌΠΈ ΡΡΠΏΠ΅ΡΠ½ΠΎΡΡΠΈ ΠΈΡΡ
ΠΎΠ΄Π° ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΡΡΠΈΡΠ°Π»ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠ΅ΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΡΡΡΠΈΡ
ΠΈ ΡΠ΅Π³ΡΠ΅ΡΡΠΈΡΡΡΡΠΈΡ
Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠ΅ΠΉ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΎΡΠ²Π΅ΡΠ° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ Π½Π° ΡΡΠΈΠΌΡΠ»ΡΡΠΈΡ ΠΎΡΠ»ΠΈΡΠ°Π»ΠΈΡΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΠΠ ΠΠΠ‘Π. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ ΡΡΠ°ΡΡΠ΅ 39 Π»Π΅Ρ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ ΡΠΈΡΠΊΠ° ΠΎΡΠΌΠ΅Π½Ρ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΠΠ ΠΠΠ‘Π ΠΈΠ·-Π·Π° ΠΎΡΡΡΡΡΡΠ²ΠΈΡ ΡΠΌΠ±ΡΠΈΠΎΠ½Π° ΠΊ 3-5 ΡΡΡΠΊΠ°ΠΌ ΠΊΡΠ»ΡΡΠΈΠ²Π°ΡΠΈΠΈ ΡΠ²Π»ΡΠ»ΠΎΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΌΠ΅Π½Π΅Π΅ 7 Π°Π½ΡΡΠ°Π»ΡΠ½ΡΡ
ΡΠΎΠ»Π»ΠΈΠΊΡΠ»ΠΎΠ² Π½Π° Π΄Π΅Π½Ρ ΡΡΠ°ΡΡΠ° ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Π°. ΠΠ΅ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΎΡ ΡΠΌΠ±ΡΠΈΠΎΠ½Π° ΠΏΡΠΈ ΠΌΠ°Π»ΠΎΠΌ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΡΠ²Π»ΡΠ»ΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ ΡΠΈΡΠΊΠ° ΠΌΠ°Π»ΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΈΠΊΠ»Π° ΠΠΠ ΠΠΠ‘Π (Π΄ΠΎ 21% ΡΠ°ΡΡΠΎΡΠ° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ). Π‘Π΅Π³ΠΌΠ΅Π½ΡΠ°ΡΠΈΡ ΡΠΈΠΊΠ»Π° Π΄Π»Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΊΡΠΈΠΎΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ° Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠΌ ΠΏΡΠ΅Π΄ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° Π°Π½Π΅ΡΠΏΠ»ΠΎΠΈΠ΄ΠΈΠΈ (ΠΠΠ’-Π) ΠΏΠΎΠ²ΡΡΠ°Π»ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Ρ 33% Π΄ΠΎ 50% Π½Π° ΠΏΠ΅ΡΠ΅Π½ΠΎΡ ΡΠΌΠ±ΡΠΈΠΎΠ½Π° Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΠΊΡΠΈΠΎΡΠΎΠ»Π΅ΡΠ°Π½ΡΠ½ΠΎΡΡΡΡ. ΠΡΠ²ΠΎΠ΄Ρ: ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π½Π° ΡΠΌΠ±ΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΡΠ°ΠΏΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΠΠ ΠΠΠ‘Π ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π²ΡΠ±ΠΎΡΠ° Π²ΡΡΠΎΠΊΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΌΠ±ΡΠΈΠΎΠ½Π° Π½Π° ΠΏΠ΅ΡΠ΅Π½ΠΎΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π»ΠΎ Π΄ΠΎΠ»Ρ ΡΡΠΏΠ΅ΡΠ½ΡΡ
ΡΠΈΠΊΠ»ΠΎΠ² ΠΠΠ ΠΠΠ‘Π ΠΏΠΎ ΡΠ°ΡΡΠΎΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠ΅ΠΉ Ρ 21 % Π΄ΠΎ 34% (Ρ<0,05) Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 35-36 Π»Π΅Ρ Ρ ΡΡΠ±ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΌ ΠΎΡΠ²Π΅ΡΠΎΠΌ Π½Π° ΡΡΠΈΠΌΡΠ»ΡΡΠΈΡ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΠΠ’-Π Π΄Π»Ρ ΠΎΡΠ±ΠΎΡΠ° ΡΠΌΠ±ΡΠΈΠΎΠ½ΠΎΠ² Π² ΡΠΈΠΊΠ»Π°Ρ
ΠΊΡΠΈΠΎΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ° ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π»ΠΎ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΈΠΊΠ»Π° ΠΠΠ ΠΠΠ‘Π Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΡΡΠ°ΡΡΠ΅ 36 Π»Π΅Ρ
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