Bulletin 114 - The Training of Public School Art Teachers

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On the Evolution of Thermonuclear Flames on Large Scales

The thermonuclear explosion of a massive white dwarf in a Type Ia supernova explosion is characterized by vastly disparate spatial and temporal scales. The extreme dynamic range inherent to the problem prevents the use of direct numerical simulation and forces modelers to resort to subgrid models to describe physical processes taking place on unresolved scales. We consider the evolution of a model thermonuclear flame in a constant gravitational field on a periodic domain. The gravitational acceleration is aligned with the overall direction of the flame propagation, making the flame surface subject to the Rayleigh-Taylor instability. The flame evolution is followed through an extended initial transient phase well into the steady-state regime. The properties of the evolution of flame surface are examined. We confirm the form of the governing equation of the evolution suggested by Khokhlov (1995). The mechanism of vorticity production and the interaction between vortices and the flame surface are discussed. The results of our investigation provide the bases for revising and extending previous subgrid-scale model.Comment: 15 pages, 22 postscript figures. Accepted for publication by the Astrophysical Journal. High resolution figures can be found at http://flash.uchicago.edu/~zhang/research_paper.htm

Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus

We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German origin. The phenotype frequency of the TNFB*I allele was significantly increased in patients compared to controls (63.6% vs 47.1%, RR = 1.96, p <0.002). The results of a two-point haplotype statistical analysis between TNFB and HLA alleles show that there is linkage disequilibrium between TNFB*I and HLA-A1, Cw7, B8, DR3, DQ2, and C4A DE. The frequency of TNFB*I was compared in SLE patients and controls in the presence or absence of each of these alleles. TNFB*I is increased in patients over controls only in the presence of the mentioned alleles. Therefore, the whole haplotypeA1, Cw7, B8, TNFB* I, C4A DE, DR3, DQ2 is increased in patients and it cannot be determined which of the genes carried by this haplotype is responsible for the susceptibility to SLE. In addition, two-locus associations were analyzed in 192 unrelated healthy controls for TNFB and class I alleles typed by serology, and for TNFB and class II alleles typed by polymerase chain reaction/oligonucleotide probes. We found positive linkage disequilibrium between TNFB*I and the following alleles: HLA-A24, HLA-B8, DRBI*0301, DRBI*ll04, DRBI*1302, DQAI*0501, DQBI*0201, DQBI*0604, and DPBI*OIO1. TNFB*2 is associated with HLA-B7, DRBI*1501, and DQB I *0602

Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).

Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Homozygous MYBPC3 mutations have been identified in these breeds but the mutations in other cats are unknown. At the clinical and physiological level feline HCM is closely analogous to human HCM but little is known about the primary causative mechanism. Most identified HCM causing mutations are in the genes coding for proteins of the sarcomere. We therefore investigated contractile and regulatory proteins in left ventricular tissue from 25 cats, 18 diagnosed with HCM, including a Ragdoll cat with a homozygous MYBPC3 R820W, and 7 non-HCM cats in comparison with human HCM (from septal myectomy) and donor heart tissue. Myofibrillar protein expression was normal except that we observed 20–44% MyBP-C haploinsufficiency in 5 of the HCM cats. Troponin extracted from 8 HCM and 5 non-HCM cat hearts was incorporated into thin filaments and studied by in vitro motility assay. All HCM cat hearts had a higher (2.06 ± 0.13 fold) Ca2+-sensitivity than non-HCM cats and, in all the HCM cats, Ca2+-sensitivity was not modulated by troponin I phosphorylation. We were able to restore modulation of Ca2+-sensitivity by replacing troponin T with wild-type protein or by adding 100 μM Epigallocatechin 3-gallate (EGCG). These fundamental regulatory characteristics closely mimic those seen in human HCM indicating a common molecular mechanism that is independent of the causative mutation. Thus, the HCM cat is a potentially useful large animal model

Ascertaining the Core Collapse Supernova Mechanism: An Emerging Picture?

Here we present the results from two sets of simulations, in two and three spatial dimensions. In two dimensions, the simulations include multifrequency flux-limited diffusion neutrino transport in the "ray-by-ray-plus" approximation, two-dimensional self gravity in the Newtonian limit, and nuclear burning through a 14-isotope alpha network. The three-dimensional simulations are model simulations constructed to reflect the post stellar core bounce conditions during neutrino shock reheating at the onset of explosion. They are hydrodynamics-only models that focus on critical aspects of the shock stability and dynamics and their impact on the supernova mechanism and explosion. In two dimensions, we obtain explosions (although in one case weak) for two progenitors (11 and 15 Solar mass models). Moreover, in both cases the explosion is initiated when the inner edge of the oxygen layer accretes through the shock. Thus, the shock is not revived while in the iron core, as previously discussed in the literature. The three-dimensional studies of the development of the stationary accretion shock instability (SASI) demonstrate the fundamentally new dynamics allowed when simulations are performed in three spatial dimensions. The predominant l=1 SASI mode gives way to a stable m=1 mode, which in turn has significant ramifications for the distribution of angular momentum in the region between the shock and proto-neutron star and, ultimately, for the spin of the remnant neutron star. Moreover, the three-dimensional simulations make clear, given the increased number of degrees of freedom, that two-dimensional models are severely limited by artificially imposed symmetries.Comment: 9 pages, 3 figure

Simulation of the Spherically Symmetric Stellar Core Collapse, Bounce, and Postbounce Evolution of a 13 Solar Mass Star with Boltzmann Neutrino Transport, and Its Implications for the Supernova Mechanism

With exact three-flavor Boltzmann neutrino transport, we simulate the stellar core collapse, bounce, and postbounce evolution of a 13 solar mass star in spherical symmetry, the Newtonian limit, without invoking convection. In the absence of convection, prior spherically symmetric models, which implemented approximations to Boltzmann transport, failed to produce explosions. We are motivated to consider exact transport to determine if these failures were due to the transport approximations made and to answer remaining fundamental questions in supernova theory. The model presented here is the first in a sequence of models beginning with different progenitors. In this model, a supernova explosion is not obtained. We discuss the ramifications of our results for the supernova mechanism.Comment: 5 pages, 3 figures, Submitted to Physical Review Letter