1,958 research outputs found

    Barriers for developing more robust organic arable farming systems in practice

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    There is a gap between the scientific idea of robust and economically viable organic arable farming systems with optimized crop rotations for nutrient and pest management and how these systems look like in practice. In order to explore this gap, we visited and interviewed ten organic arable farms in Denmark. Our main findings are: 1) Organic arable farming operates in a very dynamic and changing environment in terms of prizing and market opportunities, and the main focus of the farm managements was the coping strategy within this changing environment; 2) The farming systems were continuously changing and developing, buying and renting more land, changing manure agreements and other forms of cooperation and arrangements; 3) Short term profit was paid much more attention than more theoretical expectation on long term profit or opportunities in relation to optimizing the production system. This again seems logical in relation to the very dynamic world that the farmers have to operate within; 4) Most of the farmers do not see their farm as a coherent system but as a coordination of a series of separate operations, which means that most decisions are taken with specific reference to the individual field in at the present situation without considering the long-term effects. Management focus is thus much more on solving problems as they are occurring, by adjusting their practice, than it is on developing a robust system preventing problems to occur. This partial focus is also strongly supported by the way in which extension services mostly operate

    Picture card tool for holistic planning in organic plant production

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    Presentation of a new tool for strategic farm planning and improving farm management. The tool is based on picture cards and is meant as an important help for the advisory service for organic farmers. The tool can help the farm manager to raise the yields and the economic performance in organic plant production

    Incompatibility between fertility building measures and the management of perennial weeds in organic cropping systems

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    Fertility building measures are important components in improving the productivity of organic cropping systems without livestock. However, some measures seem to be incompatible with the control of perennial weeds that can have adverse effects such as significant weed competition. The influence of fertility building measures (N2-fixing crops in the crop sequence, cover crops and manuring) and the abundance of perennial weeds were studied in a long-term crop rotation experiment at two locations in Denmark. The aim was to gain insight into the factors that influence the growth of perennial weed species occurring in mixed stands. Data were obtained from three cycles of four-year arable crop rotations comprising various cash crops in rotations with and without annual whole-year grass-clover as green manure and subjected to four treatment combinations: with and without animal manure and with and without cover crops. Severe outbreaks of perennial weed problems did not occur at the location that had the highest soil fertility, whereas the other site demonstrated dynamic growth of Cirsium arvense and Elytrigia repens. Grain legumes tended to promote the growth of C. arvense, while manuring was neutral to C. arvense but beneficial to E. repens. Cover crops assisted the growth of E. repens since prolonged mechanical interventions were not possible. Compatibility was only achieved with grass-clover and C. arvense, meaning that green manure crops suitable for cutting and mulching could offer an important management option against C. arvense but not against E. repens

    Legacy effects of soil fertility management on cereal dry matter and nitrogen grain yield of organic arable cropping systems

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    The yields of crops in organic farming are typically lower than in conventional farming, although this depend greatly on local climatic conditions and on crop and soil management. A long-term study over three consecutive 4-year cropping cycles at three locations in Denmark compared organic arable cropping systems varying in fertilization management (green manure crops, cover crops, livestock manure) to study the long-term effects of soil fertility management on crop yields. The analysis of the results showed that the nitrogen (N) derived from cover crops has a legacy effect on the dry matter and N grain yield of spring barley being traceable 5-8 years back in time. The net N input of crop residues and manure for the crop cycles 1-4 and 5-8 years prior to the winter wheat had a significant effect on both the dry matter and N grain yield of wheat. The management of organic cropping systems should focus on reducing the weed pressure, promoting soil fertility and increasing the soil N supply to optimize crop yields. For both winter wheat and spring barley, the weed pressure reduced both crop dry matter and the N grain yield. A cover crop as pre-crop had a significant positive effect on both dry matter and N yield of spring barley, while a cover crop in the rotation did not significantly affect grain yield of winter wheat. For both winter wheat and spring barley, manure application was most effective in increasing crop yields. However, N in applied crop residues also had considerable yield-enhancing effects. For winter wheat, the N inputs from crop residues from previous crop rotation cycles (1-4 and 5-8 years) significantly increased yields, while for spring barley, N input in crop residues from incorporated cover crop and the long-term crop rotation cycle (5-8 years) significantly enhanced both dry matter and N grain yield. These legacy effects of soil fertility management through enhancing and retaining organic N inputs of organic arable cropping suggest that a holistic approach to soil and crop management is necessary, and this needs to focus on increasing weed suppression, soil fertility and targeting manure inputs for enhanced N uptake

    Polymorphism in NEDD4L Is Associated with Increased Salt Sensitivity, Reduced Levels of P-renin and Increased Levels of Nt-proANP

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    OBJECTIVE: Neuronal precursor cell expressed developmentally down-regulated 4-like (NEDD4L) is a regulator of the amiloride-sensitive epithelial sodium channel (ENaC), thus a candidate gene for salt sensitivity. Carriers of an intact NEDD4L C2-domain, encoded by the NEDD4L rs4149601 (G/A) GG genotype, together with the C-allele of the NEDD4L rs2288774 (C/T) polymorphism have previously been shown to have increased blood pressure. Our aim was to test if genetic variation in NEDD4L is associated with increased salt sensitivity. METHODS: 39 normotensive subjects were studied. The difference in 24-hour systolic blood pressure after four weeks on 150 mmol/day NaCl intake and four weeks on 50 mmol/day NaCl was defined as salt sensitivity. The rs4149601 and rs2288774 polymorphisms were genotyped using PCR-based techniques. RESULTS: Carriers of the rs4149601 GG-genotype together with the rs2288774 CC-genotype had significantly higher salt sensitivity (median, IQR) (18.0, 7.5–20.0 mmHg vs 6.0, 0.0–10.0 mmHg, P = 0.007) and lower plasma renin concentration (P-renin) (6.0, 2.0–9.5 mU/L vs 15.0, 9.0–24.0 mU/L, P = 0.005) as compared to non-carriers of these genotypes. In carriers of the rs4149601 GG-genotype together with the rs2288774 CC- or CT-genotype, as compared to non-carriers, salt sensitivity was (8.0, 6.0–18.0 mmHg vs 5.0, 0.0–10.0 mmHg, P = 0.07) and P-renin (9.0, 6.0–16.0 mU/L vs 15.0, 9.0–28.0 mU/L, P = 0.03). CONCLUSION: Genetic NEDD4L variation seems to affect salt sensitivity and P-renin in normotensive subjects, suggesting that genotyping of NEDD4L may be clinically useful in order to identify subjects who benefit from dietary salt restriction in the prevention of hypertension

    A diabetes-predictive amino acid score and future cardiovascular disease.

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    AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts development of CVD and its functional consequences.Methods and resultsWe performed a matched case-control study derived from the population-based Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC), all free of CVD. During 12 years of follow-up, 253 individuals developed CVD and were matched for age, sex, and Framingham risk score with 253 controls. Amino acids were profiled in baseline plasma samples, using liquid chromatography-tandem mass spectrometry, and relationship to incident CVD was assessed using conditional logistic regression. We further examined whether the amino acid score also correlated with anatomical [intima-media thickness (IMT) and plaque formation] and functional (exercise-induced myocardial ischaemia) abnormalities. Compared with the lowest quartile of the DM-AA score, the odds ratio (95% confidence interval) for incident CVD in subjects belonging to quartiles 2, 3, and 4 was 1.27 (0.72-2.22), 1.96 (1.07-3.60), and 2.20 (1.12-4.31) (P(trend) = 0.010), respectively, after multivariate adjustment. Increasing quartile of the DM-AA score was cross-sectionally related to carotid IMT (P(trend) = 0.037) and with the presence of at least one plaque larger than 10 mm(2) (P(trend) = 0.001). Compared with the lowest quartile of the DM-AA score, the odds ratio (95% confidence interval) for inducible ischaemia in subjects belonging to quartiles 2, 3, and 4 was 3.31 (1.05-10.4), 4.24 (1.36-13.3), and 4.86 (1.47-16.1) (P(trend) = 0.011), respectively.ConclusionThis study identifies branched-chain and aromatic amino acids as novel markers of CVD development and as an early link between diabetes and CVD susceptibility

    Outcomes of primary vs. delayed strategy of implanting a cardiac monitor for unexplained syncope.

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    OBJECTIVE: Implantable cardiac monitors (ILR) have an important role in diagnosing unexplained syncope. However, outcomes of primary vs. delayed ILR implantation after initial syncope evaluation have not been explored. METHODS: A total of 1705 patients with unexplained syncope were prospectively enrolled in the SYSTEMA (Syncope Study of Unselected Population in Malmö) cohort. Patients who underwent cardiovascular autonomic testing (CAT) and ILR were grouped into those referred to CAT after ILR implantation (primary ILR) and those in whom ILR was indicated after CAT (post-CAT ILR). RESULTS: One-hundred-and-fifteen patients (6.7%) received ILRs. ILR recipients were older (58 vs. 52 years; p = 0.002), had more syncope recurrences (6 vs. 4; p < 0.001), more traumatic falls (72% vs. 53%; p < 0.001), and less prodrome (40% vs. 55%; p = 0.005) than patients without ILRs. During follow-up ≥16 months after ILR, 67 (58%) had normal sinus rhythm, 10 (8.7%) had sinus arrest, 10 (8.7%) AV-block, 13 (11.3%) atrial fibrillation, 9 (7.8%) supraventricular tachycardia, 4 (3.5%) sinus tachycardia and 2 (1.7%) ventricular tachycardia with clinical symptom reproduction. There were 52 patients (45%) in the primary-ILR group and 63 (55%) in the post-CAT ILR group. Proportions of negative ILR monitoring (17/52 vs. 25/63; p = 0.56) and pacemaker implantations (7/52 vs. 15/63; p = 0.23) did not differ between groups. Baseline ECG conduction disorders predicted pacemaker implantation (n = 11/17; odds ratio:10.6; 95%CI: 3.15-35.3; p < 0.001). CAT was more often positive (73% vs. 40%; p < 0.001) in primary-ILR group. CONCLUSIONS: Primary ILR implantation was associated with more positive CAT compared with delayed ILR implantation, but negative monitoring and pacemaker implantations were not different between groups. ECG conduction disorders predicted subsequent pacemaker implantation

    Muligheder og barrierer for implementering af principper for robuste og højtydende planteavlssædskifter i praksis – Grundlagsrapport for barrierer undersøgelsen

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    I det økologiske forskningsprojekt, HighCrop, under GUDP - går økologiske planteavlere, konsulenter og forskere sammen om at finde ud af, hvordan planteavlen på de økologiske planteavlsbedrifter kan udvikles til at være mere robuste og bæredygtige. Et af indsatsområderne er, via interviewbesøg med 10 økologiske planteavlere, at afdække, hvordan den faglige viden når ud til landmændene og hvilke rådgivningstiltag og redskaber der bedst muligt kan understøtte denne videndeling. Denne rapport beskriver det teoretiske og metodiske grundlag for denne barriere undersøgels

    Hypertension and Genetic Variation in Endothelial-Specific Genes

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    Genome-wide association (GWA) studies usually detect common genetic variants with low-to-medium effect sizes. Many contributing variants are not revealed, since they fail to reach significance after strong correction for multiple comparisons. The WTCCC study for hypertension, for example, failed to identify genome-wide significant associations. We hypothesized that genetic variation in genes expressed specifically in the endothelium may be important for hypertension development. Results from the WTCCC study were combined with previously published gene expression data from mice to specifically investigate SNPs located within endothelial-specific genes, bypassing the requirement for genome-wide significance. Six SNPs from the WTCCC study were selected for independent replication in 5205 hypertensive patients and 5320 population-based controls, and successively in a cohort of 16537 individuals. A common variant (rs10860812) in the DRAM (damage-regulated autophagy modulator) locus showed association with hypertension (P = 0.008) in the replication study. The minor allele (A) had a protective effect (OR = 0.93; 95% CI 0.88-0.98 per A-allele), which replicates the association in the WTCCC GWA study. However, a second follow-up, in the larger cohort, failed to reveal an association with blood pressure. We further tested the endothelial-specific genes for co-localization with a panel of newly discovered SNPs from large meta-GWAS on hypertension or blood pressure. There was no significant overlap between those genes and hypertension or blood pressure loci. The result does not support the hypothesis that genetic variation in genes expressed in endothelium plays an important role for hypertension development. Moreover, the discordant association of rs10860812 with blood pressure in the case control study versus the larger Malmo "Preventive Project-study highlights the importance of rigorous replication in multiple large independent studies

    Cardiovascular risk after hospitalisation for unexplained syncope and orthostatic hypotension

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    OBJECTIVE: To investigate the relationship of hospital admissions due to unexplained syncope and orthostatic hypotension (OH) with subsequent cardiovascular events and mortality. METHODS: We analysed a population-based prospective cohort of 30 528 middle-aged individuals (age 58±8 years; males, 40%). Adjusted Cox regression models were applied to assess the impact of unexplained syncope/OH hospitalisations on cardiovascular events and mortality, excluding subjects with prevalent cardiovascular disease. RESULTS: After a median follow-up of 15±4 years, 524 (1.7%) and 504 (1.7%) participants were hospitalised for syncope or OH, respectively, yielding 1.2 hospital admissions per 1000 person-years for each diagnosis. Syncope hospitalisations increased with age (HR, per 1 year: 1.07, 95% CI 1.05 to 1.09), higher systolic blood pressure (HR, per 10 mm Hg: 1.06, 95% CI 1.01 to 1.12), antihypertensive treatment (HR: 1.26, 95% CI 1.00 to 1.59), use of diuretics (HR: 1.77, 95% CI 1.31 to 2.38) and prevalent cardiovascular disease (HR: 1.59, 95% CI 1.14 to 2.23), whereas OH hospitalisations increased with age (HR: 1.11, 95% CI 1.08 to 1.12) and prevalent diabetes (HR: 1.82, 95% CI 1.23 to 2.70). After exclusion of 1399 patients with prevalent cardiovascular disease, a total of 473/464 patients were hospitalised for unexplained syncope/OH before any cardiovascular event. Hospitalisation for unexplained syncope predicted coronary events (HR: 1.85, 95% CI 1.49 to 2.30), heart failure (HR: 2.24, 95% CI 1.65 to 3.04), atrial fibrillation (HR: 1.84, 95% CI 1.50 to 2.26), aortic valve stenosis (HR: 2.06, 95% CI 1.28 to 3.32), all-cause mortality (HR: 1.22, 95% CI 1.09 to 1.37) and cardiovascular death (HR: 1.72, 95% CI 1.23 to 2.42). OH-hospitalisation predicted stroke (HR: 1.66, 95% CI 1.24 to 2.23), heart failure (HR: 1.78, 95% CI 1.21 to 2.62), atrial fibrillation (HR: 1.89, 95% CI 1.48 to 2.41) and all-cause mortality (HR: 1.14, 95% CI 1.01 to 1.30). CONCLUSIONS: Patients discharged with the diagnosis of unexplained syncope or OH show higher incidence of cardiovascular disease and mortality with only partial overlap between these two conditions
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