1,207 research outputs found
Irredundant Triangular Decomposition
Triangular decomposition is a classic, widely used and well-developed way to
represent algebraic varieties with many applications. In particular, there
exist sharp degree bounds for a single triangular set in terms of intrinsic
data of the variety it represents, and powerful randomized algorithms for
computing triangular decompositions using Hensel lifting in the
zero-dimensional case and for irreducible varieties. However, in the general
case, most of the algorithms computing triangular decompositions produce
embedded components, which makes it impossible to directly apply the intrinsic
degree bounds. This, in turn, is an obstacle for efficiently applying Hensel
lifting due to the higher degrees of the output polynomials and the lower
probability of success. In this paper, we give an algorithm to compute an
irredundant triangular decomposition of an arbitrary algebraic set defined
by a set of polynomials in C[x_1, x_2, ..., x_n]. Using this irredundant
triangular decomposition, we were able to give intrinsic degree bounds for the
polynomials appearing in the triangular sets and apply Hensel lifting
techniques. Our decomposition algorithm is randomized, and we analyze the
probability of success
Search for emission of unstable Be clusters from hot Ca and Ni nuclei
The possible occurence of highly deformed configurations is investigated in
the Ca and Ni di-nuclear systems as formed in the Si +
C and Si + Si reactions, respectively, by using the
properties of emitted light charged particles. Inclusive as well as exclusive
data of the heavy fragments (A 6) and their associated light charged
particles (p, d, t, and -particles) have been collected at the IReS
Strasbourg VIVITRON Tandem facility with two bombarding energies
Si) = 112 and 180 MeV by using the ICARE charged particle
multidetector array, which consists of nearly 40 telescopes. The measured
energy spectra, velocity distributions, in-plane and out-of-plane angular
correlations are analysed by Monte Carlo CASCADE statistical-model calculations
using a consistent set of parameters with spin-dependent level densities.
Although significant deformation effects at high spin are needed, the remaining
disagreement observed in the Si + C reaction for the S
evaporation residue suggests an unexpected large unstable Be cluster
emission of a binary nature.Comment: 13 pages latex, 9 eps figures. Paper presented at the XXXIX
International Winter Meeting on Nuclear Physics, Bormio(Italy) January 22-27,
2001 (to be published at Ricerca Scientifica ed Educazione Permanente
Down syndrome and postoperative complications after paediatric cardiac surgery: a propensity-matched analysis
OBJECTIVESThe incidence of congenital heart disease is approximately 50%, mostly related to endocardial cushion defects. The aim of our study was to investigate the postoperative complications that occur after paediatric cardiac surgery.METHODSOur perioperative data were analysed in paediatric patients with Down syndrome undergoing cardiac surgery. We retrospectively analysed the data from 2063 consecutive paediatric patients between January 2003 and December 2008. After excluding the patients who died or had missing data, the analysed database (before propensity matching) contained 129 Down patients and 1667 non-Down patients. After propensity matching, the study population comprised 222 patients and 111 patients had Down syndrome.RESULTSBefore propensity matching, the occurrences of low output syndrome (21.2 vs 32.6%, P = 0.003), pulmonary complication (14 vs 28.7%, P < 0.001) and severe infection (11.9 vs 22.5%, P = 0.001) were higher in the Down group. Down patients were more likely to have prolonged mechanical ventilation [median (interquartile range) 22 (9-72) h vs 49 (24-117) h, P = 0.007]. The total intensive care unit length of stay [6.9 (4.2-12.4) days vs 8.3 (5.3-13.2) days, P = 0.04] and the total hospital length of stay [17.3 (13.3-23.2) days vs 18.3 (15.1-23.6) days, P = 0.05] of the Down patients were also longer. Mortality was similar in the two groups before (3.58 vs 3.88%, P = 0.86) and after (5.4 vs 4.5%, P = 1.00) propensity matching. After propensity matching, there was no difference in the occurrence of adverse events.CONCLUSIONSAfter propensity matching Down syndrome was not associated with increased mortality or complication rate following congenital cardiac surgery
Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial
Objective: Assess ustekinumab efficacy (week 24/week 52) and safety (week 16/week 24/week 60) in patients with active psoriatic arthritis (PsA) despite treatment with conventional and/or biological anti-tumour necrosis factor (TNF) agents.
Methods: In this phase 3, multicentre, placebo-controlled trial, 312 adults with active PsA were randomised (stratified by site, weight (≤100â
kg/>100â
kg), methotrexate use) to ustekinumab 45â
mg or 90â
mg at week 0, week 4, q12 weeks or placebo at week 0, week 4, week 16 and crossover to ustekinumab 45â
mg at week 24, week 28 and week 40. At week 16, patients with <5% improvement in tender/swollen joint counts entered blinded early escape (placeboâ45â
mg, 45â
mgâ90â
mg, 90â
mgâ90â
mg). The primary endpoint was ≥20% improvement in American College of Rheumatology (ACR20) criteria at week 24. Secondary endpoints included week 24 Health Assessment Questionnaire-Disability Index (HAQ-DI) improvement, ACR50, ACR70 and ≥75% improvement in Psoriasis Area and Severity Index (PASI75). Efficacy was assessed in all patients, anti-TNF-naĂŻve (n=132) patients and anti-TNF-experienced (n=180) patients.
Results: More ustekinumab-treated (43.8% combined) than placebo-treated (20.2%) patients achieved ACR20 at week 24 (p<0.001). Significant treatment differences were observed for week 24 HAQ-DI improvement (p<0.001), ACR50 (p≤0.05) and PASI75 (p<0.001); all benefits were sustained through week 52. Among patients previously treated with ≥1 TNF inhibitor, sustained ustekinumab efficacy was also observed (week 24 combined vs placebo: ACR20 35.6% vs 14.5%, PASI75 47.1% vs 2.0%, median HAQ-DI change â0.13 vs 0.0; week 52 ustekinumab-treated: ACR20 38.9%, PASI75 43.4%, median HAQ-DI change â0.13). No unexpected adverse events were observed through week 60.
Conclusions: The interleukin-12/23 inhibitor ustekinumab (45/90â
mg q12 weeks) yielded significant and sustained improvements in PsA signs/symptoms in a diverse population of patients with active PsA, including anti-TNF-experienced PsA patients
Deformation effects in the Si+C and Si+Si reaction Search
The possible occurence of highly deformed configurations is investigated in
the Ca and Ni di-nuclear systems as formed in the
Si+C,Si reactions by using the properties of emitted light
charged particles. Inclusive as well as exclusive data of the heavy fragments
and their associated light charged particles have been collected by using the
{\sc ICARE} charged particle multidetector array. The data are analysed by
Monte Carlo CASCADE statistical-model calculations using a consistent set of
parameters with spin-dependent level densities. Significant deformation effects
at high spin are observed as well as an unexpected large Be cluster
emission of a binary nature.Comment: 3 pages latex, 2 eps figures, paper presented in "wokshop on physics
with multidetector array (pmda2000)Calcutta, India (to be published at
PRAMANA, journal of Physics, India
Vanishing spin alignment : experimental indication of triaxial nuclear molecule
Fragment-fragment- coincidences have been measured for at an energy corresponding to the population of a conjectured
resonance in Ni. Fragment angular distributions as well as -ray
angular correlations indicate that the spin orientations of the outgoing
fragments are perpendicular to the orbital angular momentum. This differs from
the and the resonances, and
suggests two oblate nuclei interacting in an equator-to-equator
molecular configuration.Comment: 14 pages standard REVTeX file, 3 ps Figures -- Accepted for
publication in Physical Review C (Rapid Communication
Deformation effects in Ni nuclei produced in Si+Si at 112 MeV
Velocity and energy spectra of the light charged particles (protons and
-particles) emitted in the Si(E = 112 MeV) + Si
reaction have been measured at the Strasbourg VIVITRON Tandem facility. The
ICARE charged particle multidetector array was used to obtain exclusive spectra
of the light particles in the angular range 15 - 150 degree and to determine
the angular correlations of these particles with respect to the emission angles
of the evaporation residues. The experimental data are analysed in the
framework of the statistical model. The exclusive energy spectra of
-particles emitted from the Si + Si compound system are
generally well reproduced by Monte Carlo calculations using spin-dependent
level densities. This spin dependence approach suggests the onset of large
deformations at high spin. A re-analysis of previous -particle data
from the Si + Si compound system, using the same spin-dependent
parametrization, is also presented in the framework of a general discussion of
the occurrence of large deformation effects in the A ~ 60 mass region.Comment: 25 pages, 6 figure
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