19 research outputs found
ΠΠ΅Π΄Π΅Π½ΠΈΠ΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ Ρ Π΄Π΅ΡΠΈΡΠΈΡΠΎΠΌ ΠΌΠ°Π³Π½ΠΈΡ: ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅
Background: no multicenter studies to assess the prevalence of Magnesium (Mg) deficiency in the general population,Β particularly among pregnant women have been previously conducted in Russia. Objectives: to evaluate Mg deficiency incidence andΒ management in a pregnant population monitored in Russian polyclinics. Materials and Methods: pregnant women (at any trimester)Β aged over 18 years were included. Mg deficiencies due to any other concomitant condition were exclusion criteria. Data coming fromΒ medical records were collected at Visit 1 and visit 2 (1 month +/- 1 week): complete medical history; diagnosis of Mg deficiencyΒ confirmed by serum Mg level (<0.7 mmol/l) routine laboratory tests performed in the course of current practice (blood count, MgΒ plasma determination and urinalysis) and evaluation of total score (superior 30) using a structured 28 questions self-administratedΒ Magnesium Deficiency Questionnaire (MDQ). Spontaneous reports of adverse reactions were collected. The statistical tests wereΒ applied according to type of variable distribution (the Shapiro-Wilkestest) and the estimation of equality of variances (Levene's testΒ of Homogeneity of Variance). If two terms were true the Studentβs t-test was used, alternatively the Wilcoxon-Mann-Whitney-TestΒ was used. Paired samples t-test or Wilcoxon test were run for the comparison of changes in study continuous variables. Chi-squareΒ (Ο2) and Fischer's exact tests were used for comparisons of categorical data. Results: 1130 pregnant women, mean age 28.95Β±5 yearsΒ were included. Estimated combining prevalence of Mg deficiency according to the blood plasma levels (<0.7 mmol) and MDQ wasΒ 81,2%. It was observed that physicians commonly prescribe different organic Mg salts to pregnant women with Mg deficiency as aΒ routine practice. Thus, Mg was prescribed to 1110 pregnant women: 84.1% received Mg Citrate (933/1110) and 21.3% (177/1110)Β Mg lactate. At the 1 visit the Mg deficiency according to MDQ score analysis was observed in 80.3% (870/1083) and at the end of theΒ program only 5.75% (62/1083; Ρ<0,001) presented Mg deficiency. An improvement of Mg deficiency signs evaluated using a MDQΒ was observed. Thus, the mean MDQ score significantly decreased by 22.6Β±11.9 points (Baseline: 15.8Β±7.9; Final visit 38.3Β±13.4Β points; Ρ<0,001). During the observational registry period one ADR was reported as an allergic dermatitis in a woman receiving MgΒ Citrate. Conclusions: the study identified a high prevalence of Mg deficiency in pregnant women population. The prevalence of MgΒ deficiency was 81.2%. It was observed that organic Mg salts are commonly prescribed by physicians to pregnant women with establishedΒ Mg deficiency and statistically significant improvement in Mg deficiency signs in pregnant women receiving organic Mg saltsΒ was observed. To confirm these findings in other populations leaving across the Russian Federation, it is necessary to conduct anΒ additional study with increased sample size, especially considering the age distribution of the population (women of childbearing age)Β and the life style.ΠΠ½ΠΎΠ³ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΌΠ°Π³Π½ΠΈΡ Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΆΠ΅Π½ΡΠΈΠ½ Π² Π ΠΎΡΡΠΈΠΈ ΡΠ°Π½Π΅Π΅ Π½Π΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ. Π¦Π΅Π»Ρ: ΠΎΡΠ΅Π½ΠΊΠ° ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΌΠ°Π³Π½ΠΈΡ ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π°ΠΌΠ±ΡΠ»Π°ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π²Π΅Π΄Π΅Π½ΠΈΡ Π²ΡΠ°ΡΠ°ΠΌΠΈ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ Π΄Π΅ΡΠΈΡΠΈΡΠΎΠΌ ΠΌΠ°Π³Π½ΠΈΡ Π² ΡΠ΅Π°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ: Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ»ΠΈ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΆΠ΅Π½ΡΠΈΠ½Ρ ΡΡΠ°ΡΡΠ΅ 18 Π»Π΅Ρ (Π² Π»ΡΠ±ΠΎΠΌ ΡΡΠΈΠΌΠ΅ΡΡΡΠ΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ). ΠΠ΅ΡΠΈΡΠΈΡ ΠΌΠ°Π³Π½ΠΈΡ Π² ΡΠ²ΡΠ·ΠΈ Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΠΏΡΠΈΡΠΈΠ½Π°ΠΌΠΈ ΡΠ²Π»ΡΠ»ΡΡ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅ΠΌ ΠΈΡΠΊΠ»ΡΡΠ΅Π½ΠΈΡ. Π‘Π±ΠΎΡ Π΄Π°Π½Π½ΡΡ
ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π΄Π²ΡΡ
Π²ΠΈΠ·ΠΈΡΠΎΠ² (2-ΠΉ Π²ΠΈΠ·ΠΈΡ β ΡΠ΅ΡΠ΅Π· 1 ΠΌΠ΅Ρ. +/- 1 Π½Π΅Π΄Π΅Π»Ρ ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ). ΠΠ΅ΡΠΈΡΠΈΡ ΠΌΠ°Π³Π½ΠΈΡ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΡΡ ΠΏΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊΠ° (28 Π²ΠΎΠΏΡΠΎΡΠΎΠ²) ΠΈ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ Π΄Π°Π½Π½ΡΠΌΠΈ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠ΅ΡΡΠΎΠ². Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ±ΡΠ°Π±Π°ΡΡΠ²Π°Π»ΠΈΡΡ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΡΠΈΠΏΠΎΠΌ ΠΏΠ΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ (ΡΠ΅ΡΡ Π¨Π°ΠΏΠΈΡΠΎ-Π£ΠΈΠ»ΠΊΡΠ°) ΠΈ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠ°Π²Π΅Π½ΡΡΠ²Π° Π΄ΠΈΡΠΏΠ΅ΡΡΠΈΠΉ (ΠΊΡΠΈΡΠ΅ΡΠΈΠΉ ΠΠ΅Π²Π΅Π½Π° β ΠΎΠ΄Π½ΠΎΡΠΎΠ΄Π½ΠΎΡΡΠΈ Π΄ΠΈΡΠΏΠ΅ΡΡΠΈΠΈ). Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΈΠ½ΡΠ»ΠΈ ΡΡΠ°ΡΡΠΈΠ΅ 1130 Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΆΠ΅Π½ΡΠΈΠ½, ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ β 28,95Β±5 Π»Π΅Ρ. Π Π°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΌΠ°Π³Π½ΠΈΡ Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΏΠΎ ΠΎΠ±ΡΠ΅ΠΉ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΡΠΎΠ²Π½Ρ ΠΌΠ°Π³Π½ΠΈΡ Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ (<0,7 ΠΌΠΌΠΎΠ»Ρ) ΠΈ Π΄Π°Π½Π½ΡΡ
Π°Π½ΠΊΠ΅ΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 81,2%. ΠΡΠ°ΡΠΈ Π΄Π»Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΆΠ΅Π½ΡΠΈΠ½ Ρ Π΄Π΅ΡΠΈΡΠΈΡΠΎΠΌ ΠΌΠ°Π³Π½ΠΈΡ Π² ΡΡΡΠΈΠ½Π½ΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΡΠ°ΡΡΠΎ Π½Π°Π·Π½Π°ΡΠ°ΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΠ»ΠΈ ΠΌΠ°Π³Π½ΠΈΡ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΠΌΠ°Π³Π½ΠΈΡ Π±ΡΠ»ΠΈ Π½Π°Π·Π½Π°ΡΠ΅Π½Ρ 1110 Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ ΠΆΠ΅Π½ΡΠΈΠ½Π°ΠΌ: 933 ΠΏΠΎΠ»ΡΡΠΈΠ»ΠΈ ΡΠΈΡΡΠ°Ρ ΠΌΠ°Π³Π½ΠΈΡ ΠΈ 177 β Π»Π°ΠΊΡΠ°Ρ ΠΌΠ°Π³Π½ΠΈΡ. ΠΠ΅ΡΠΈΡΠΈΡ ΠΌΠ°Π³Π½ΠΈΡ, ΠΏΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ Π°Π½ΠΊΠ΅ΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ, Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠΌΠ΅Π½ΡΡΠΈΠ»ΡΡ: Ρ 15,8Β±7,9 Π±Π°Π»Π»Π° Π½Π° ΠΏΠ΅ΡΠ²ΠΎΠΌ Π²ΠΈΠ·ΠΈΡΠ΅ Π΄ΠΎ 38,3Β±13,4 Π±Π°Π»Π»Π° Π½Π° ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅ΠΌ; Ρ<0,001. ΠΡΠ²ΠΎΠ΄Ρ: ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π° Π½ΠΈΠ΅ Π²ΡΡΠ²ΠΈΠ»ΠΎ Π²ΡΡΠΎΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΌΠ°Π³Π½ΠΈΡ Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΆΠ΅Π½ΡΠΈΠ½. Π Π°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΌΠ°Π³Π½ΠΈΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 81,2%. ΠΠ»Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΡΠΌ Π΄Π΅-ΡΠΈΡΠΈΡΠΎΠΌ ΠΌΠ°Π³Π½ΠΈΡ Π²ΡΠ°ΡΠ°ΠΌΠΈ Π½Π°Π·Π½Π°ΡΠ°ΡΡΡΡ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΠ»ΠΈ ΠΌΠ°Π³Π½ΠΈΡ Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Ρ ΠΏΠΈΡΠΈΠ΄ΠΎΠΊΡΠΈΠ½ΠΎΠΌ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠ΅ΡΡ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡΡ
SAFETY ASPECTS OF USING DROTAVERINE IN OBSTETRIC PATIENTS
Summary Safety of pharmacotherapy during pregnancy is of paramount importance for the woman and the fetus. There is an increasing number of pediatric diseases with unclear or presumably genetic etiology (autism, mental illness, oncology, obesity, diabetes, etc.). In this respect, more attention is being paid to the epigenetic or fetal programming, and the safety of pharmacotherapy during the gestation period and lactation, as well as 3-9 months before conception (periconception period)
Oxidative stress, endothelial dysfunction, cytokine imbalance, gonadotropic synergism, or all about tocopherol in the practice of an obstetrician-gynecologist
Generation of reactive oxygen species (ROS) occurs in every human. The condition of oxidative stress develops when the human antioxidant defenses including the enzymes superoxide dismutase, peroxidases etc., and biological antioxidant molecules, are insufficient. Vitamin E is part of the antioxidant family. It plays a key role in neutralizing ROS, and its scope of activity ranges from the inhibition of heme biosynthesis and lipid peroxidation to maintaining the collagen/elastin balance. Vitamin E deficiency may be either primary or secondary; both shift the balance towards the development of oxidative stress, which may affect the normal course of pregnancy. As a result, pregnancy loss or preterm birth may ensue. Moreover, the oxidative stress can have a negative impact on the development of a fetus. In addition, the oxidative stress may play a role in various female reproductive disorders, eventually leading to infertility. In the todayβs world, the popular commitment to low-cholesterol and low-fat diets often leads to an increasing number of women with vitamin E deficiency. In order to maintain normal pregnancy, this imbalance requires an adequate correction starting at the stage of preconception care
CLINICAL CASE OF EXTRAUTERINE PREGNANCY, LOCATED IN RUDIMENTAL UTERINE HORN AT 21-22 WEEK OF GESTATION
In article the question is a case of extrauterine pregnancy in term of 21-22 weeks in the rudimentary horn of a uterus in term of 21-22 weeks interrupted because of break of a horn with an intrabelly bleeding. The operation and tactical approaches to conducting the given case are described