Assessment of poststress left ventricular ejection fraction by gated SPECT: comparison with equilibrium radionuclide angiocardiography

PURPOSE: We compared left ventricular (LV) ejection fraction obtained by gated SPECT with that obtained by equilibrium radionuclide angiocardiography in a large cohort of patients. METHODS: Within 1 week, 514 subjects with suspected or known coronary artery disease underwent same-day stress-rest (99m)Tc-sestamibi gated SPECT and radionuclide angiocardiography. For both studies, data were acquired 30 min after completion of exercise and after 3 h rest. RESULTS: In the overall study population, a good correlation between ejection fraction measured by gated SPECT and by radionuclide angiocardiography was observed at rest (r=0.82, p<0.0001) and after stress (r=0.83, p<0.0001). In Bland-Altman analysis, the mean differences in ejection fraction (radionuclide angiocardiography minus gated SPECT) were -0.6% at rest and 1.7% after stress. In subjects with normal perfusion (n=362), a good correlation between ejection fraction measured by gated SPECT and by radionuclide angiocardiography was observed at rest (r=0.72, p<0.0001) and after stress (r=0.70, p<0.0001) and the mean differences in ejection fraction were -0.9% at rest and 1.4% after stress. Also in patients with abnormal perfusion (n=152), a good correlation between the two techniques was observed both at rest (r=0.89, p<0.0001) and after stress (r=0.90, p<0.0001) and the mean differences in ejection fraction were 0.1% at rest and 2.5% after stress. CONCLUSION: In a large study population, a good agreement was observed in the evaluation of LV ejection fraction between gated SPECT and radionuclide angiocardiography. However, in patients with perfusion abnormalities, a slight underestimation in poststress LV ejection fraction was observed using gated SPECT as compared to equilibrium radionuclide angiocardiography

Supersymmetry of a Nonstationary Pauli Equation

The supersymmetry of the electron in both the nonstationary magnetic and electric fields in a two-dimensional case is studied. The supercharges which are the integrals of motion and their algebra are established. Using the obtained algebra the solutions of nonstationary Pauli equation are generated.Comment: 12 pages, Late

Motion of a spin 1/2 particle in shape invariant scalar and magnetic fields

We study the motion of a spin 1/2 particle in a scalar as well as a magnetic field within the framework of supersymmetric quantum mechanics(SUSYQM). We also introduce the concept of shape invariant scalar and magnetic fields and it is shown that the problem admits exact analytical solutions when such fields are considered.Comment: 14 page

Photon creation in a spherical oscillating cavity

We study the photon creation inside a perfectly conducting, spherical oscillating cavity. The electromagnetic field inside the cavity is described by means of two scalar fields which satisfy Dirichlet and (generalized) Neumann boundary conditions. As a preliminary step, we analyze the dynamical Casimir effect for both scalar fields. We then consider the full electromagnetic case. The conservation of angular momentum of the electromagnetic field is also discussed, showing that photons inside the cavity are created in singlet states.Comment: 14 pages, no figure

Comparison of bioelectrical impedance analysis and dual-energy X-ray absorptiometry for the assessment of appendicular body composition in anorexic women

Objective: To establish the accuracy of bioelectrical impedance analysis (BIA) for the assessment of appendicular body composition in anorexic women. Design: Cross-sectional study. Setting: Outpatient University Clinic. Subjects: A total of 39 anorexic and 25 control women with a mean (s.d.) age of 21 (3) y. Methods: Total, arm and leg fat-free mass (FFM) were measured by dual-energy X-ray absorptiometry and predicted from total and segmental BIA at 50 kHz. The predictor variable was the resistance index (Rl), that is, the ratio of height 2 to body resistance for the whole body and the ratio of length2/limb resistance for the arm and leg. Results: Predictive equations developed on controls overestimated total, arm and leg FFM in anorexics (Po0.0001). Populationspecific equations gave a satisfactory estimate of total and appendicular FFM in anorexics (P\ubcNS) but had higher percent root mean square errors (RMSEs%) as compared to those developed on controls (8% vs 5% for whole body, 12% vs 10% for arm and 10% vs 8% for leg). The accuracy of the estimate of total and leg FFM in anorexics was improved by adding body weight (Wt) as a predictor with Rl (RMSE%\ubc5% vs 8% and 7% vs 10%, respectively). However, the same accuracy was obtained using Wt alone, suggesting that in anorexics, BIA at 50 kHz is not superior to Wt for assessing total and leg FFM. Conclusion: BIA shows some potential for the assessment of appendicular body composition in anorexic women. However, Wt is preferable to BIA at 50 kHz on practical grounds. Further studies should consider whether frequencies 450 kHz give better estimates of appendicular composition in anorexics as compared to Wt

Superevolution

Usually, in supersymmetric theories, it is assumed that the time-evolution of states is determined by the Hamiltonian, through the Schr\"odinger equation. Here we explore the superevolution of states in superspace, in which the supercharges are the principal operators. The superevolution equation is consistent with the Schr\"odinger equation, but it avoids the usual degeneracy between bosonic and fermionic states. We discuss superevolution in supersymmetric quantum mechanics and in a simple supersymmetric field theory.Comment: 23 page

Exercise-rest Tc-99m tetrofosmin SPECT in patients with chronic ischemic left ventricular dysfunction: Direct comparison with Tl-201 reinjection

Background. This study was designed to compare the results of exercise-rest technetium-99m tetrofosmin single photon emission computed tomography (SPECT) with those of thallium-201 reinjection at rest after exercise-redistribution imaging in the same patients with chronic ischemic left ventricular (LV) dysfunction. Methods. Within 1 week, 33 patients with chronic myocardial infarction and LV dysfunction underwent exercise-rest tetrofosmin SPECT and Tl-201 reinjection at rest after exercise-redistribution imaging. In each patient, regional tetrofosmin and Tl-201 activity was quantitatively measured in 22 myocardial segments. Regional LV function was assessed in corresponding segments by echocardiography. Results. Agreement in the evaluation of regional perfusion status between tetrofosmin and Tl-201 imaging was observed in 78% of the 726 total segments, with a κ value of 0.61. In segments with normal function at echocardiography (n = 436), no difference between Tl-201 and tetrofosmin uptake was observed. In hypokinetic segments (n = 138), exercise tetrofosmin uptake was lower (P &lt; .01) as compared with exercise Tl-201 activity, whereas no difference was observed between tetrofosmin uptake at rest as compared with Tl-201 activity on redistribution and reinjection images. In segments with severe functional impairment (akinetic or dyskinetic, n = 152), tetrofosmin uptake on exercise images was reduced (P &lt; .01) as compared with exercise Tl-201 activity; furthermore, tetrofosmin uptake at rest was lower (P &lt; .01) as compared with Tl-201 activity on both redistribution and reinjection images. In these segments, concordance in the detection of myocardial viability between tetrofosmin and Tl-201 imaging was observed in 138 (91%) of the 152 segments, with a κ value of 0.77. Conclusions. In patients with chronic coronary artery disease and LV dysfunction quantitative exercise-rest tetrofosmin and Tl-201 reinjection SPECT provide similar information in the assessment of perfusion status and in the detection of myocardial viability

On the construction of variant supergravities in D=11, D=10

We construct with a geometric procedure the supersymmetry transformation laws and Lagrangian for all the ``variant'' D=11 and D=10 Type IIA supergravities. We identify into our classification the D=11 and D=10 Type IIA ``variant'' theories first introduced by Hull performing T-duality transformation on both spacelike and timelike circles. We find in addition a set of D=10 Type IIA ``variant'' supergravities that can not be obtained trivially from eleven dimensions compactifying on a circle.Comment: 21 pages, Late

Effective Actions for Massive Kaluza-Klein States on AdS_3 x S^3 x S^3

We construct the effective supergravity actions for the lowest massive Kaluza-Klein states on the supersymmetric background AdS_3 x S^3 x S^3. In particular, we describe the coupling of the supergravity multiplet to the lowest massive spin-3/2 multiplet which contains 256 physical degrees of freedom and includes the moduli of the theory. The effective theory is realized as the broken phase of a particular gauging of the maximal three-dimensional supergravity with gauge group SO(4) x SO(4). Its ground state breaks half of the supersymmetries leading to 8 massive gravitinos acquiring mass in a super Higgs effect. The holographic boundary theory realizes the large N=(4,4) superconformal symmetry.Comment: 31 pages, v2: minor change

Kaluza-Klein supergravity on AdS_3 x S^3

We construct a Chern-Simons type gauged N=8 supergravity in three spacetime dimensions with gauge group SO(4) x T_\infty over the infinite dimensional coset space SO(8,\infty)/(SO(8) x SO(\infty)), where T_\infty is an infinite dimensional translation subgroup of SO(8,\infty). This theory describes the effective interactions of the (infinitely many) supermultiplets contained in the two spin-1 Kaluza-Klein towers arising in the compactification of N=(2,0) supergravity in six dimensions on AdS_3 x S^3 with the massless supergravity multiplet. After the elimination of the gauge fields associated with T_\infty, one is left with a Yang Mills type gauged supergravity with gauge group SO(4), and in the vacuum the symmetry is broken to the (super-)isometry group of AdS_3 x S^3, with infinitely many fields acquiring masses by a variant of the Brout-Englert-Higgs effect.Comment: LaTeX2e, 24 pages; v2: references update