359 research outputs found
Leukocyte margination in alveolar capillaries: Interrelationship with functional capillary geometry and microhemodynamics
The pulmonary capillary microvasculature harbors a large pool of intravascularly marginated leukocytes. In this study, we investigated the interrelationship of leukocyte margination with characteristics of functional capillary geometry and microhemodynamics in alveolar capillary networks. In 22 anesthetized rabbits we assessed functional capillary density, average capillary length, red blood cell velocity and leukocyte kinetics in alveolar capillary networks in vivo by intravital fluorescence microscopy. In alveolar wall areas of 12,800 +/- 1,800 mu m(2), we detected 3.6 +/- 0.5 sticking leukocytes and 21.0 +/- 1.9 functional capillary segments with an average capillary length of 35.7 +/- 2.1 mu m. We calculated that approximately 15% of functional capillary segments are blocked by marginated leukocytes. Leukocyte margination was predominantly observed in capillary networks characterized by a high functional capillary density, short capillary segments and low red blood cell velocities. The multitude of interconnected capillary channels in these networks may allow alveolar blood flow to bypass marginated leukocytes. Hence, this interrelationship may be relevant for maintenance of adequate alveolar perfusion and low capillary network resistance despite excessive leukocyte margination in the pulmonary microvasculature. Local microhemodynamic factors may play a regulatory role in the spatial distribution of leukocyte margination
Universality of weakly bound dimers and Efimov trimers close to Li-Cs Feshbach resonances
We study the interspecies scattering properties of ultracold Li-Cs mixtures
in their two energetically lowest spin channels in the magnetic field range
between 800 G and 1000 G. Close to two broad Feshbach resonances we create
weakly bound LiCs dimers by radio-frequency association and measure the
dependence of the binding energy on the external magnetic field strength. Based
on the binding energies and complementary atom loss spectroscopy of three other
Li-Cs s-wave Feshbach resonances we construct precise molecular singlet and
triplet electronic ground state potentials using a coupled-channels
calculation. We extract the Li-Cs interspecies scattering length as a function
of the external field and obtain almost a ten-fold improvement in the precision
of the values for the pole positions and widths of the s-wave Li-Cs Feshbach
resonances as compared to our previous work [Pires \textit{et al.}, Phys. Rev.
Lett. \textbf{112}, 250404 (2014)]. We discuss implications on the Efimov
scenario and the universal geometric scaling for LiCsCs trimers
Frequency and timing system for the consolidated DSN and STDN tracking network
The consolidation on the existing Deep Space Network (DSN) and colocated Goddard Spaceflight Tracking and Data Network (STDN) stations into a multiple antenna array is discussed. Each site includes a signal processing center (SPC) centered in an array of four or five antennas each located within approximately 300 to 800 meters of the SPC. A central frequency and timing system (FTS) located in the SPC contains reference frequency, timing and time code generation, and distribution equipment for both the SPC and each antenna with its associated front end antenna control building. The reference frequency distribution and clock equipment are driven by a hydrogen maser as the prime frequency standard with cesium beam frequency standard as the secondary
Bragg spectroscopy of a strongly interacting Fermi gas
We present a comprehensive study of the Bose-Einstein condensate to
Bardeen-Cooper-Schrieffer (BEC-BCS) crossover in fermionic Li using Bragg
spectroscopy. A smooth transition from molecular to atomic spectra is observed
with a clear signature of pairing at and above unitarity. These spectra probe
the dynamic and static structure factors of the gas and provide a direct link
to two-body correlations. We have characterised these correlations and measured
their density dependence across the broad Feshbach resonance at 834 G.Comment: Replaced with published versio
Recommended from our members
Sugar intake among German adolescents: trends from 1990-2016 based on biomarker excretion in 24-h urine samples
Trend analyses based on dietary records suggest decreases in the intakes of total (TS), added (AS) and free sugar (FS) since 2005 among children and adolescents in Germany. In terms of age trends, TS intake decreased with increasing age. However, self-reported sugar intake in epidemiological studies is criticized, as it may be prone to bias due to selective underreporting. Furthermore, adolescents are more susceptible to underreporting than children. We thus analyzed time and age trends in urinary fructose excretion (FE), sucrose excretion (SE) and the sum of both (FE+SE) as biomarkers for sugar intake among 8.5-16.5-year-old adolescents. Urinary sugar excretion was measured by UPLC-MS/MS in 997 24-h urine samples collected from 239 boys and 253 girls participating in the DONALD study cohort between 1990 and 2016. Time and age trends of log-transformed FE, SE and FE+SE were analyzed using polynomial mixed-effects regression models. Between 1990 and 2016 FE as well as FE+SE decreased (linear time trend: p=0.0272 and p<0.0001, respectively). A minor increase in excretion during adolescence was confined to FE (linear age trend: p=0.0017). The present 24-h excretion measurements support a previously reported dietary-record based decline in sugar intake since 2005. However, the previous seen dietary record-based decrease in TS from childhood to late adolescence was not confirmed by our biomarker analysis, suggesting a constant sugar intake for the period of adolescence
Universal three-body recombination and Efimov resonances in an ultracold Li-Cs mixture
We study Efimov resonances via three-body loss in an ultracold two-component
gas of fermionic Li and bosonic Cs atoms close to a Feshbach
resonance at 843~G, extending results reported previously [Pires \textit{et
al.}, Phys. Rev. Lett. 112, 250404 (2014)] to temperatures around 120~nK. The
experimental scheme for reaching lower temperatures is based upon compensating
the gravity-induced spatial separation of the mass-imbalanced gases with
bichromatic optical dipole traps. We observe the first and second excited
Li-Cs-Cs Efimov resonance in the magnetic field dependence of the three-body
event rate constant, in good agreement with the universal zero-range theory at
finite temperature [Petrov and Werner, Phys. Rev. A 92, 022704 (2015)].
Deviations are found for the Efimov ground state, and the inelasticity
parameter is found to be significantly larger than those for
single-species systems
Leukocyte sequestration in pulmonary microvessels and lung injury following systemic complement activation in rabbits
Inflammatory reactions are associated with sequestration of leukocytes in the lung. Complement activation leads to accumulation of leukocytes in alveolar septa and alveoli, to lung edema and hemorrhage. Although in organs other than the lung leukocytes interact with the vascular endothelium only in postcapillary venules, alveolar capillaries are considered to be the site of leukocyte sequestration in the lung. However, pulmonary venules and arterioles have not been investigated systematically after complement activation so far, A closed thoracic window was implanted in anesthetized rabbits; leukocytes and red blood cells were stained, and the movement of these cells was measured in superficial pulmonary arterioles, venules and alveolar capillaries using fluorescence video microscopy before and 30 and 60 min after infusion of cobra venom factor (CVF). Erythrocyte velocity and macrohemodynamic conditions did not change after CVF infusion and were not different from the sham-treated controls. The number of sticking leukocytes increased significantly compared to baseline and control: by 150% in arterioles and in venules and by 740% in alveolar capillaries within 60 min after CVF infusion. The width of alveolar septa in vivo was significantly enlarged after CVF infusion, indicating interstitial pulmonary edema. At the end of the experiments, myeloperoxidase activity was higher in the CVF group, showing leukocyte sequestration in the whole organ. It is concluded that complement activation by CVF induces leukocyte sequestration in lung arterioles, venules and alveolar capillaries and leads to mild lung injury
- …