Experimental Investigation and Numerical Modelling of Dynamic Behaviour of Screw Compressor Plant

An experimental and analytical study of screw compressor operation under unsteady conditions has been carried out. For this purpose a one dimensional model of the processes within a compressor was extended to include other plant components, including tanks and connecting piping. This was based on the differential equations of conservation of mass and energy. The results derived from the model have been verified by experiment in order to obtain a reliable tool that can simulate a variety of scenarios which may occur in everyday compressor plant operation. The analytical model was then further developed to demonstrate whole plant transient operation when a screw compressor is connected with storage tanks, control valves and heat exchangers in a complete system

Current aspects of the epidemiology and treatment of chronic brain ischemiain the presence of essential hypertension (results of the CALIPSO program)

The paper gives the results of the multicenter clinical and epidemiological program CALIPSO (Cavinton in the treatment of patients with chronic cerebral circulatory disorder: dyscirculatory encephalopathy in the presence of essential hypertension). The program covered 4865 patients with chronic hypertension-related cerebrovascular insufficiency from 42 cities and towns of the Russian Federation. The patients received dropwise intravenous Cavinton as infusions within the first week (25 mg on days 1 to 4 and 50 mg on days 5 to 7) then oral Cavinton forte, 30 mg/day, for 90 days. Therapy with Cavinton and Cavinton forte led to improvements in health, balance (the Tinnetti scale), and cognitive functions (the mini mental state examination). This study has provided evidence for the safety of Cavinton

Cerebral venous disorders: diagnosis, clinical features

Most reports on vascular pathology of the brain have been devoted to arterial blood flow, while morphometric studies of the brain have demonstrated that approximately 85% of the vascular bed of the brain accounts for venous vessels, 10% accounts for the arteries, and about 5% accounts for capillaries. Nevertheless, only a few studies regarding venous pathology of the brain have been published. Many authors admit that the arterial and venous segments of the vascular bed represent a complex interdependent system, where the venous segment is considered to be a highly organized reflexogenic zone responsible for the development of complex, physiologically important, compensatory reactions that provide the constancy of cerebral blood flow. Venous circulation disorders, cerebral venous dyscirculations (CVDs), as well as thromboses of the intracranial veins and sinuses, comprise a significant part of vascular lesions of the brain. The etiologic and pathogenetic aspects of CVD, as well as of thromboses of the intracranial veins and sinuses, have been analyzed. The issues of diagnosis and management of patients with cerebral venous disorders have been considered. Clinical manifestations and characteristics of progression of this pathology have been presented. Cerebral venous thromboses and CVP are often severe, but potentially treatable diseases. Knowledge of the main clinical symptom complexes makes it possible to timely diagnose this pathology and perform effective differentiated pathogenetic and symptomatic therapy in these patients

ANALYSIS OF THE SERT AND TPH2 GENES POLYMORPHISM RELATIONSHIP WITH SIDE EFFECTS DURING TOPIRAMATE THERAPY TAKING INTO ACCOUNT GENDER FEATURES

We examined the clinical and genetic evaluation of SERT and TPH2 genes SNP polymorphisms role in the development of side effects during topiramate therapy taking into account gender features. Found significant differences in the severity of topiramate side effects in the nervous system and psycho-emotional sphere in patient groups with different variants of alleles, and identified gender features in elaboration of depression and emotional labilit

Inelastic Relaxation of Oxygen and Low-Field Magnetoresistance in La0.65\text{}_{0.65}Ca0.35\text{}_{0.35}MnO3\text{}_{3} Films on Ferroelectric Ceramics Substrates

Galvanomagnetic properties of polycrystalline La$\text{}_{0.65}$Ca$\text{}_{0.35}$MnO$\text{}_{3}$ films with a thickness of 0.2~μm deposited onto Pb$\text{}_{2.9}$Ba$\text{}_{0.05}$Sr$\text{}_{0.05}$(Zr$\text{}_{0.4}$Ti$\text{}_{0.6}$)O$\text{}_{3}$ ferroelectric ceramics substrates were investigated. We discovered an irreversible increase in film resistance after numerous inversions of substrate polarization. This phenomenon was investigated several times for three film structures. The typical duration of the process of a monotonic 3-5 times increase in film resistance was 3-6 hours. The long-time relaxation of macroscopic film resistance is explained by dielectrization of film intercrystallite boundaries. The typical size of crystallites of both the film and the substrate is 3-10μm. Such small size explains the fact of macroscopic homogeneity of film conductivity, when the specific resistance increases from 1.8×10$\text{}^{-2}$ to 1.8Ω cm. A growth in resistance of narrow (10 nm) regions of film is explained by the redistribution of oxygen anions under the action of inhomogeneous mechanical stress. The stress between crystallites appears due to inverse piezoelectric effect of ferroelectric substrate. The magnitude of diffusion coefficient of oxygen is estimated to be D≥10$\text{}^{-20}$ m$\text{}^{2}$ s$\text{}^{-1}$

EXPERIENCE OF USING LAKOSAMID IN VARIOUS FORMS OF EPILEPSY (The results of observational study in city outpatient health care chain of Moscow)

This paper presents experience of using Vimpat in outpatient health care chain of Moscow. In the observational study were attended 49 patients with difficult for treatment focal forms of epilepsy (cryptogenic and symptomatic forms). Vimpat used in complex therapy in the mean effective dose of 300-400 mg per day. As a result, the data on a cohort of Russian patients showed that Vimpat demonstrate a sufficiently high clinical efficacy (55%, p<0.01) and appropriate for use in patients with difficult for treatment forms of epilepsy in complex therapy when the previous treatment was ineffective

EXPERIENCE OF TREATMENT WITH GENERIC LAMOTRIDJIN IN DIFFERENT FORMS OF EPILEPSY (The results of focus observation in out-patient clinics network of Moscow city public healthcare services)

Focused observational study on efficacy, tolerability and quality of life in adult patients with different forms of epilepsy taking combined therapy with lamotrigine (Sazar). 32 patients (19 men and 13 women), 23-79 years old with focal forms (cryptogenic and symptomatic) epilepsy with different disease duration and presence of of different type and etiology seizures were enrolled into the study. Patients having been taken various antiepileptic drugs in monotherapy with different efficacy degree were observed. Patients sample included 20 patients, receiving valproic acid in various dosages and 12 patients, receiving topiramate. Sazar was added as a second drug with initial dosage of 25 mg daily. Results of focused observation allow us to make conclusion of possible expedience of Sazar indication, especially in patients in whom therapy with valproic acid is less effective