Force indeterminacy in the jammed state of hard disks

Granular packings of hard discs are investigated by means of contact dynamics which is an appropriate technique to explore the allowed force-realizations in the space of contact forces. Configurations are generated for given values of the friction coefficient, and then an ensemble of equilibrium forces is found for fixed contacts. We study the force fluctuations within this ensemble. In the limit of zero friction the fluctuations vanish in accordance with the isostaticity of the packing. The magnitude of the fluctuations has a non-monotonous friction dependence. The increase for small friction can be attributed to the opening of the angle of the Coulomb cone, while the decrease as friction increases is due to the reduction of connectivity of the contact-network, leading to local, independent clusters of indeterminacy. We discuss the relevance of indeterminacy to packings of deformable particles and to the mechanical response properties.Comment: 4 pages, 3 figures. Minor changes, journal reference adde

Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era.

BackgroundFew adolescents and young adults (AYAs, 15-39 years old) enroll onto cancer clinical trials, which hinders research otherwise having the potential to improve outcomes in this unique population. Prior studies have reported that AYAs are more likely to receive cancer care in community settings. The National Cancer Institute (NCI) has led efforts to increase trial enrollment through its network of NCI-designated cancer centers (NCICC) combined with community outreach through its Community Clinical Oncology Program (CCOP; replaced by the NCI Community Oncology Research Program in 2014).MethodsUsing AYA proportional enrollment (the proportion of total enrollments who were AYAs) as the primary outcome, we examined enrollment of AYAs onto SWOG therapeutic trials at NCICC, CCOP, and non-NCICC/non-CCOP sites from 2004 to 2013 by type of site, study period (2004-08 vs 2009-13), and patient demographics.ResultsOverall, AYA proportional enrollment was 10.1%. AYA proportional enrollment decreased between 2004-2008 and 2009-2013 (13.1% vs 8.5%, P < .001), and was higher at NCICCs than at CCOPs and non-NCICC/non-CCOPs (14.1% vs 8.3% and 9.2%, respectively; P < .001). AYA proportional enrollment declined significantly at all three site types. Proportional enrollment of AYAs who were Black or Hispanic was significantly higher at NCICCs compared with CCOPs or non-NCICC/non-CCOPs (11.5% vs 8.8, P = .048 and 11.5% vs 8.6%, P = .03, respectively).ConclusionNot only did community sites enroll a lower proportion of AYAs onto cancer clinical trials, but AYA enrollment decreased in all study settings. Initiatives aimed at increasing AYA enrollment, particularly in the community setting with attention to minority status, are needed

A limit on nonlocality in any world in which communication complexity is not trivial

Bell proved that quantum entanglement enables two space-like separated parties to exhibit classically impossible correlations. Even though these correlations are stronger than anything classically achievable, they cannot be harnessed to make instantaneous (faster than light) communication possible. Yet, Popescu and Rohrlich have shown that even stronger correlations can be defined, under which instantaneous communication remains impossible. This raises the question: Why are the correlations achievable by quantum mechanics not maximal among those that preserve causality? We give a partial answer to this question by showing that slightly stronger correlations would result in a world in which communication complexity becomes trivial.Comment: 13 pages, no figure

Unjamming due to local perturbations in granular packings with and without gravity

We investigate the unjamming response of disordered packings of frictional hard disks with the help of computer simulations. First, we generate jammed configurations of the disks and then force them to move again by local perturbations. We study the spatial distribution of the stress and displacement response and find long range effects of the perturbation in both cases. We record the penetration depth of the displacements and the critical force that is needed to make the system yield. These quantities are tested in two types of systems: in ideal homogeneous packings in zero gravity and in packings settled under gravity. The penetration depth and the critical force are sensitive to the interparticle friction coefficient. Qualitatively, the same nonmonotonic friction dependence is found both with and without gravity, however the location of the extrema are at different friction values. We discuss the role of the connectivity of the contact network and of the pressure gradient in the unjamming response.Comment: 12 pages, 13 figure

Resonant continuum in the Hartree-Fock+BCS approximation

A method for incorporating the effect of the resonant continuum into Hartree-Fock+BCS equations is proposed. The method is applied for the case of a neutron-rich nucleus calculated with a Skyrme-type force plus a zero-range pairing interaction and the results are compared with Hartree-Fock-Bogoliubov calculations. It is shown that the widths of resonant states have an important effect on the pairing properties of nuclei close to the drip line.Comment: 9 pages, 2 figures, comparison with HFB adde

Single-Molecule Fluorescence Observed with Mercury Lamp Illumination

We demonstrate that it is possible to observe single fluorescent molecules using a standard fluorescence microscope with mercury lamp excitation and an inexpensive cooled charge-coupled device (CCD) camera. With this equipment, we have been able to observe single molecules of tetramethyl-rhodamine, rhodamine 6G, fluorescein isothiocyanate and green fluorescent protein. Immobilized molecules were observed both in air and in aqueous solution

Single-Molecule Fluorescence Observed with Mercury Lamp Illumination

We demonstrate that it is possible to observe single fluorescent molecules using a standard fluorescence microscope with mercury lamp excitation and an inexpensive cooled charge-coupled device (CCD) camera. With this equipment, we have been able to observe single molecules of tetramethyl-rhodamine, rhodamine 6G, fluorescein isothiocyanate and green fluorescent protein. Immobilized molecules were observed both in air and in aqueous solution

On the Nature of Intrinsic Absorption in Reddened Seyfert 1 Galaxies

We discuss the origin of the ``dusty lukewarm absorber'', which we previously identified in the reddened Seyfert 1 galaxies NGC 3227 and Akn 564. This absorber is characterized by saturated UV absorption lines (C IV, N V) near the systemic velocity of the host galaxy, and is likely responsible for reddening both the continuum and the emission lines (including those from the narrow-line region) from these Seyferts. From a large sample of Seyfert 1 galaxies, we find that continuum reddening (as measured by UV color) tends to increase with inclination of the host galaxy. Furthermore, reddened, inclined Seyfert galaxies observed at moderate to high spectral resolution all show evidence for dusty lukewarm absorbers. We suggest that these absorbers lie in the plane of the host galaxy at distances > 100 pc from the nucleus, and are physically distinct from the majority of intrinsic absorbers that are outflowing from the nucleus.Comment: 14 pages, including 2 figures, accepted for publication in the Astrophysical Journal (Letters

Detailed Radio Spectra of Selected Compact Sources in the Nucleus of M82

We have determined detailed radio spectra for 26 compact sources in the starburst nucleus of M82, between 74 and 1.3 cm. Seventeen show low-frequency turnovers. One other has a thermal emission spectrum, and we identify it as an HII region. The low frequency turnovers are due to absorption by the interstellar gas in M82. New information on the AGN candidate 44.01+595, shows it to have a non-thermal falling powerlaw spectrum at the highest frequencies, and that it is strongly absorbed below 2 GHz. We derive large magnetic fields in the supernova remnants, of order 1-2 milliGauss, hence large pressures in the sources suggest that the brightest ones are either expanding or are strongly confined by a dense interstellar medium. From the largest source in our sample, we derive a supernova rate of 0.016 SN/yr.Comment: 19 pages, 7 tables, 29 figures, LaTeX, requires AAS macros v. 4.0. To appear in ApJ July 20, 199