Materials Modelling and Modal Analysis of the Lighthouse in the Venetian Harbour of Chania

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Using Sentinel-1A DInSAR interferometry and Landsat 8 data for monitoring water level changes in two lakes in Crete, Greece

Differential Interferometric Synthetic Aperture Radar (DInSAR) methodology has been successfully employed to detect water level changes and produce corresponding water level variation maps. In this study, Agia and Kournas lakes, located in Western Crete, Greece, were used as pilot areas to monitor water level change with means of SAR interferometry and auxiliary Earth Observation (EO) data. The water level variation was monitored for the period 2015–2016, using Sentinel-1A imageries and corresponding stage water level data. Landsat 8 data were additionally used to study vegetation regime and surface water extent and how these parameters affect interferograms performance. The results highlighted the fact that the combination of SAR backscattering intensity and unwrapped phase can provide additional insight into hydrological studies. The overall analysis of both interferometric characteristics and backscattering mechanism denoted their potential in enhancing the reliability of the water-level retrieval scheme and optimizing the capture of hydrological patterns spatial distribution

Stapedotomy in osteogenesis imperfecta patients

Osteogenesis imperfecta (OI) is a connective tissue disorder characterized by osseous fragility, blue sclerae and hearing loss. In order to assess the impact of stapedotomy on improving hearing on OI, a retrospective, one-group, pre-test-post-test design was used to compare the pre-operative and post-operative audiograms of nine OI patients, treated with stapedotomy for their mixed hearing loss. Operative findings included fixation or thickening of the stapes footplate with normal superstructure configuration and hypervascularization of the promontory mucosa. Immediate post-operative results showed a significant improvement (p<0.05) from 250-4000 Hz in air conduction and from 250-2000 Hz in bone conduction. A significant closure of the air-bone gap between 250-2000 Hz was also achieved (p<0.05). The long-term results remained satisfactory with a mean threshold shift of 8 dB HL and an almost unchanged air-bone gap. These satisfactory results and the lack of complications make stapedotomy an appealing method for the management of OI-associated hearing loss

Novel Full Hydrogenation Reaction of Methyl Esters of Palm Kernel and Sunflower Oils Into Methyl Stearate Catalyzed by Rhodium, Ruthenium and Nickel Complexes of Bidentate Hexasulfonated o-Phenylendiphosphite Ligands

High catalytic activities (TOF = 8680 h −1 ) have been achieved by novel rhodium catalysts modified with the chelating sulfonated phosphite ligand hexasulfonated o-phenylendiphosphite in the hydrogenation reaction of renewable methyl esters of sunflower oil under mild reaction conditions and a low rhodium concentration of 50 ppm in methanol. Graphical Abstract: [Figure not available: see fulltext.]. © 2019, Springer Science+Business Media, LLC, part of Springer Nature

Partial laryngectomy after irradiation failure

INTRODUCTION: Radiation therapy is often the first method of treating patients with early cancer of the glottis. There is a substantial failure rate among these patients. Total laryngectomy has usually been the means of treating patients with failure after radiation. In recent decades, partial laryngectomy has been used for salvage in such patients. This article will discuss the use of partial laryngectomy for radiation failure both from the oncologic result as well as the morbidity. PATIENTS AND METHODS: Between 1984 and 1995, 27 patients with early-stage laryngeal carcinoma underwent salvage partial laryngectomy after irradiation failure. Vertical laryngectomy was performed in 18 patients (13 with T1 N0 and 5 with T2 N0) and horizontal-supraglottic laryngectomy in 9 patients (3 with T1 N0, 1 with T2 N0, and 5 with T2 N1). The mean follow-up was 4.1 years. RESULTS: Local control was obtained in 77.7% of patients with glottic lesions (T1: 84.6%; T2: 60%, P = NS) and in 55.5% of patients with supraglottic lesions (T1: 66.6%; T2: 50%; P = NS). There was no regional recurrence in the vertical laryngectomy group, whereas the regional control rate in the horizontal-supraglottic laryngectomy group was 77.7%. Distant control was achieved in 94.4% of patients with glottic disease and in 77.7% of patients with supraglottic disease. The overall survival rate for glottic lesions was 88.8% (T1: 92.3%; T2: 80%; P = NS) versus 66.6% for supraglottic lesions (T1: 100%; T2: 50%; P = NS). CONCLUSION AND SIGNIFICANCE: Vertical laryngectomy was not associated with an increased complication rate. Morbidity in the horizontal-supraglottic laryngectomy group was higher, but a satisfactory functional outcome was obtained in all cases. Therefore, in early laryngeal cancer (glottic T1 42, supraglottic T1) partial laryngectomy can be performed with good expectation of cure and satisfactory laryngeal function. In T2 supraglottic lesions, the oncologic results are less satisfactory; further research is required for developing more efficient complimentary or alternative treatments modalities

mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene (HIF1A): An independent predictor of poor overall survival in chronic lymphocytic leukemia

The hypoxia inducible factor 1 (HIF1) is a heterodimeric transcription factor that ultimately regulates cellular responses to changes in oxygen tension. In this study, we examined the potential diagnostic and prognostic potential of the mRNA expression of HIF1 regulatory α-subunit (HIF1A) in chronic lymphocytic leukemia (CLL). For this purpose, total RNA was isolated from peripheral blood mononuclear cells collected from 88 CLL patients and 33 non-leukemic blood donors, and poly(A)-RNA was reversely transcribed. HIF1A mRNA levels were quantified using real-time PCR. Kaplan-Meier survival analysis showed that high HIF1A mRNA expression predicts inferior overall survival for CLL patients (p = 0.001). Bootstrap univariate Cox regression analysis confirmed that HIF1A mRNA overexpression is a significant unfavorable prognosticator in CLL (hazard ratio = 3.75, bias-corrected and accelerated 95% confidence interval = 1.43–24.36, bootstrap p < 0.001), independent of other established prognostic factors, including CD38 expression, the mutational status of the immunoglobulin heavy chain variable region (IGHV), and the clinical stage (Binet or Rai stage) or risk group (p < 0.001 in all cases). Interestingly, HIF1A mRNA positivity retains its unfavorable prognostic value in distinct subgroups of patients, stratified according to established prognostic factors. Thus, HIF1A mRNA overexpression can be regarded as a promising, independent molecular biomarker of unfavorable prognosis in CLL. © 2016 Elsevier Lt

Service configuration and traffic distribution in composite radio environments

This paper adopts the assumption that cellular, broadband fixed wireless access (BFWA), wireless local area networks (WLAN), and digital video broadcasting (DVB) systems can be co-operating components of a composite-radio infrastructure. It is believed that through the composite radio concept, operators will be enabled to offer efficient, in terms of cost and QoS, wireless access to broadband IP-based services. The exploitation of this infrastructure calls for the application of computational intelligence (CI) technologies for the development of appropriate, sophisticated service and network resource management functionality. In this context, this paper identifies and addresses the important problem of service configuration and distribution in a composite radio environment (SCD-CRE). The problem's objective is to determine the best way to accommodate a demand volume, with which the composite radio infrastructure is faced. The problem finds the QoS levels that can be offered, and the networks that can support the demand at the selected QoS levels. The paper includes a first approach to the definition, mathematical formulation, and solution of a version of the SCD-CRE problem. Results indicating some of the capabilities of the SCD-CRE are also presented. Further application fields for CI technologies are indicated, in the area of the necessary reconfiguration of the managed, radio and fixed, network segments