VisGenome: visualization of single and comparative genome representations

VisGenome visualizes single and comparative representations for the rat, the mouse and the human chromosomes at different levels of detail. The tool offers smooth zooming and panning which is more flexible than seen in other browsers. It presents information available in Ensembl for single chromosomes, as well as homologies (orthologue predictions including ortholog one2one, apparent ortholog one2one, ortholog many2many) for any two chromosomes from different species. The application can query supporting data from Ensembl by invoking a link in a browser

Green's function for a Schroedinger operator and some related summation formulas

Summation formulas are obtained for products of associated Lagurre polynomials by means of the Green's function K for the Hamiltonian H = -{d^2\over dx^2} + x^2 + Ax^{-2}, A > 0. K is constructed by an application of a Mercer type theorem that arises in connection with integral equations. The new approach introduced in this paper may be useful for the construction of wider classes of generating function.Comment: 14 page

VLBI Probes of Jet Physics in Neutrino-Candidate Blazars

In recent years, evidence has accumulated that some high-energy cosmic neutrinos can be associated with blazars. The strongest evidence for an individual association was found in the case of the blazar TXS 0506+056 in 2017. In July 2019, another track-like neutrino event (IC190730A) was found spatially coincident with the well-known bright flat-spectrum radio quasar PKS 1502+106. PKS 1502+106 was not found to be in a particularly elevated gamma-ray state, but exhibited a remarkably bright radio outburst at the time of the neutrino detection, similar to TXS 0506+056. We have performed a multi-frequency VLBI study from 15 GHz up to 86 GHz on TXS 0506+056, PKS 1502+106 and one additional neutrino-candidate blazar (PKS 0215+015) to study the radio structure of neutrino candidate blazars in response to their neutrino association. We have obtained target of opportunity observations with the VLBA for all three sources within $\sim$1 month from their associated neutrino events and are performing multi-epoch studies of the jet kinematics at 15 GHz as part of the MOJAVE program. Here, we present first results on TXS 0506+056 at 86 GHz and one additional 43 GHz image obtained 27 days after IC170922A, closer in time to the neutrino event than previously published images. We also give an overview about our recent work on PKS 1502+106 and PKS 0215+015.Comment: 8 pages, 1 figure, 1 table, Proceedings of 38th International Cosmic Ray Conference (ICRC2023

Resource use by patients hospitalized with community-acquired pneumonia in Europe: analysis of the REACH study

Background: Management of community-acquired pneumonia (CAP) places a considerable burden on hospital resources. REACH was a retrospective, observational study (NCT01293435) involving adults >= 18 years old hospitalized with CAP and requiring in-hospital treatment with intravenous antibiotics conducted to collect data on current clinical management patterns and resource use for CAP in hospitals in ten European countries. Methods: Data were collected via electronic Case Report Forms detailing patient and disease characteristics, microbiological diagnosis, treatments before and during hospitalization, clinical outcomes and health resource consumption. Results: Patients with initial antibiotic treatment modification (n = 589; 28.9%) had a longer mean hospital stay than those without (16.1 [SD: 13.1; median 12.0] versus 11.1 {SD: 8.9; median: 9.0] days) and higher ICU admission rate (18.0% versus 11.9%). Septic shock (6.8% versus 3.0%), mechanical ventilation (22.2% versus 9.7%), blood pressure support (fluid resuscitation: 19.4% versus 11.4%), parenteral nutrition (6.5% versus 3.9%) and renal replacement therapy (4.2% versus 1.4%) were all more common in patients with treatment modification than in those without. Hospital stay was longer in patients with comorbidities than in those without (mean 13.3 [SD: 11.1; median: 10.0] versus 10.0 [SD: 7.5; median: 8.0] days). Conclusions: Initial antibiotic treatment modification in patients with CAP is common and is associated with considerable additional resource use. Reassessment of optimal management paradigms for patients hospitalized with CAP may be warranted