Ketamine kinetics in unmedicated and diazepam‐premedicated subjects

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109775/1/cptclpt1984235.pd

Opioid Modulation of Oxytocin Release

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97182/1/0091270010361256.pd

Plasma phencyclidine pharmacokinetics in dog and monkey using a gas chromatography selected ion monitoring assay

Phencyclidine was determined by gas chromatography selected ion monitoring in six dogs and seven monkeys. Aliquots of venous blood were taken over 4 h in the monkey after 1.1 mg kg−1 and over 24 h in the dog after 1.0 mg kg−1 of phencyclidine i.v. Pentadeuterated phencyclidine was used as the internal standard. In the electron impact mode the most abundant fragments in the mass spectrum of phencyclidine were m/e 91 and 200, and 96 and 205 in the [2H5]phencyclidine spectrum. These fragments were used to quantitate the amount of phencyclidine present. In both species, a complex exponential decline of plasma phencyclidine was found in most animals that fit a two compartment open model. In monkey, the mean half‐life (β phase) was 2.36 h and in the dog it was 2.86 h. Compared with the monkey, the dog exhibited considerable emergence delirium. The two species had rather different pharmacokinetics which may be relevant to the observed differences in degree of anesthesia and recovery.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144632/1/bms1200050203.pd

Positron emission tomography to quantify brain nicotine abstinence

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110042/1/cptclpt2005379.pd

Effects of urine acidification on plasma and urine phencyclidine levels in overdosage

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117118/1/cpt1977224421.pd

Gas chromatographic-mass spectrometric analysis of polybrominated biphenyl constituents of Firemaster FF-1

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23145/1/0000069.pd

Effects of repeated doses of scopolamine on the electroencephalographic stages of sleep in normal volunteers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117155/1/cpt1975186727.pd

The Plasma Interaction Experiment (PIX) description and test program

The plasma interaction experiment (PIX) is a battery powered preprogrammed auxiliary payload on the LANDSAT-C launch. This experiment is part of a larger program to investigate space plasma interactions with spacecraft surfaces and components. The varying plasma densities encountered during available telemetry coverage periods are deemed sufficient to determine first order interactions between the space plasma environment and the biased experimental surfaces. The specific objectives of the PIX flight experiment are to measure the plasma coupling current and the negative voltage breakdown characteristics of a solar array segment and a gold plated steel disk. Measurements will be made over a range of surface voltages up to plus or minus kilovolt. The orbital environment will provide a range of plasma densities. The experimental surfaces will be voltage biased in a preprogrammed step sequence to optimize the data returned for each plasma region and for the available telemetry coverage

Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats

Varying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted and assayed by pyrolysis gas-liquid chromatography. Total brain acetylcholine (ACh) levels were not significantly different among the control animals in all three groups. d-Amphetamine, however, decreased total levels of ACh in young and geriatric rats without changing levels in adult animals. The changes in young rats were dose-related. These results suggest an important difference in brain cholinergic mechanisms depending upon age.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22339/1/0000784.pd

Comparative American and Japanese tobacco smoke uptake parameters after overnight tobacco deprivation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109819/1/cptclpt2004281.pd