63 research outputs found
An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes
Cancers are characterized by non-random chromosome copy number alterations that presumably contain oncogenes and tumor-suppressor genes (TSGs). The affected loci are often large, making it difficult to pinpoint which genes are driving the cancer. Here we report a cross-species in vivo screen of 84 candidate oncogenes and 39 candidate TSGs, located within 28 recurrent chromosomal alterations in ependymoma. Through a series of mouse models, we validate eight new ependymoma oncogenes and ten new ependymoma TSGs that converge on a small number of cell functions, including vesicle trafficking, DNA modification and cholesterol biosynthesis, identifying these as potential new therapeutic targets.We are grateful to F.B. Gertler (Massachusetts Institute of Technology) and S. Gupton (University of North Carolina) for the generous gift of the VAMP7-phlorin construct and the staffs of the Hartwell Center for Bioinformatics and Biotechnology, the Small Animal Imaging Center, the Animal Resources Center, the Cell and Tissue Imaging Center, and the Flow Cytometry and Cell Sorting Shared Resource at St. Jude Children's Research Hospital for technical assistance. This work was supported by grants from the US National Institutes of Health (R01CA129541, P01CA96832 and P30CA021765, R.J.G.), by the Collaborative Ependymoma Research Network (CERN) and by the American Lebanese Syrian Associated Charities (ALSAC)
Role of genetic testing for inherited prostate cancer risk: Philadelphia prostate cancer consensus conference 2017
Purpose: Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-dri
Salivary DNA methylation panel to diagnose HPV-positive and HPV-negative head and neck cancers
Animal husbandry in the Early and Middle Neolithic settlement at KopydĆowo in the Polish lowlands. A multi-isotope perspective
Omics-based molecular techniques in oral pathology centred cancer: Prospect and challenges in Africa
: The completion of the human genome project and the accomplished milestones in the human
proteome project; as well as the progress made so far in computational bioinformatics and âbig dataâ processing have
contributed immensely to individualized/personalized medicine in the developed world.At the dawn of precision medicine, various omics-based therapies and bioengineering can now be
applied accurately for the diagnosis, prognosis, treatment, and risk stratifcation of cancer in a manner that was
hitherto not thought possible. The widespread introduction of genomics and other omics-based approaches into
the postgraduate training curriculum of diverse medical and dental specialties, including pathology has improved
the profciency of practitioners in the use of novel molecular signatures in patient management. In addition, intricate
details about disease disparity among diferent human populations are beginning to emerge. This would facilitate the
use of tailor-made novel theranostic methods based on emerging molecular evidences
The topographic evolution of the Tibetan Region as revealed by palaeontology
The Tibetan Plateau was built through a succession of Gondwanan terranes colliding with Asia during the Mesozoic. These accretions produced a complex Paleogene topography of several predominantly eastâwest trending mountain ranges separated by deep valleys. Despite this piecemeal assembly and resultant complex relief, Tibet has traditionally been thought of as a coherent entity rising as one unit. This has led to the widely used phrase âthe uplift of the Tibetan Plateauâ, which is a false concept borne of simplistic modelling and confounds understanding the complex interactions between topography climate and biodiversity. Here, using the rich palaeontological record of the Tibetan region, we review what is known about the past topography of the Tibetan region using a combination of quantitative isotope and fossil palaeoaltimetric proxies, and present a new synthesis of the orography of Tibet throughout the Paleogene. We show why âthe uplift of the Tibetan Plateauâ never occurred, and quantify a new pattern of topographic and landscape evolution that contributed to the development of todayâs extraordinary Asian biodiversity
Antibodies Against Cysteine String Proteins Inhibit Evoked Neurotransmitter Release at Xenopus
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