Experimental study and evaluation of radioprotective drugs

Experimental study evaluates radioprotective drugs administered before exposure either orally or intravenously. Specifically studied are the sources of radiation, choice of radiation dose, choice of animals, administration of drugs, the toxicity of protective agents and types of protective drug

Rubber-coated bellows improves vibration damping in vacuum lines

Compact-vibration damping systems, consisting of rubber-coated metal bellows with a sliding O-ring connector, are used in vacuum lines. The device presents a metallic surface to the vacuum system and combines flexibility with the necessary stiffness. It protects against physical damage, reduces fatigue failure, and provides easy mating of nonparallel lines

A viscoelastic traction layer model of mucociliary flow

A new mathematical model of the transport of mucus and periciliary liquid (PCL) in the airways by cilia is presented. Mucus is represented by a linearly viscoelastic fluid, the mat of cilia is modelled as an ‘active porous medium.’ The propulsive effect of the cilia is modelled by a time-dependent force acting in a shear-thinned ‘traction layer’ between the mucus and the PCL. The effects of surface and interface tension are modelled by constraining the mucus free surface and mucus–PCL interface to be flat. It is assumed that the epithelium is impermeable to fluid. Using Fourier series, the system is converted into ODEs and solved numerically. We calculate values for mean mucus speed close to those observed by Matsui et~al. [{J. Clin. Invest.}, 102(6):1125’1131, 1998], (~40 μms−1). We obtain more detail regarding the dynamics of the flow and the nonlinear relationships between physical parameters in healthy and diseased states than in previously published models. Pressure gradients in the PCL caused by interface and surface tension are vital to ensuring efficient transport of mucus, and the role of the mucus–PCL interface appears to be to support such pressure gradients, ensuring efficient transport. Mean transport of PCL is found to be very small, consistent with previous analyses, providing insight into theories regarding the normal tonicity of PCL

CFD Mixing Analysis of Jets Injected from Straight and Slanted Slots into Confined Crossflow in Rectangular Ducts

A CFD study was performed to analyze the mixing potential of opposed rows of staggered jets injected into confined crossflow in a rectangular duct. Three jet configurations were numerically tested: (1) straight (0 deg) slots; (2) perpendicular slanted (45 deg) slots angled in opposite directions on top and bottom walls; and (3) parallel slanted (45 deg) slots angled in the same direction on top and bottom walls. All three configurations were tested at slot spacing-to-duct height ratios (S/H) of 0.5, 0.75, and 1.0; a jet-to-mainstream momentum flux ratio (J) of 100; and a jet-to-mainstream mass flow ratio of 0.383. Each configuration had its best mixing performance at S/H of 0.75. Asymmetric flow patterns were expected and predicted for all slanted slot configurations. The parallel slanted slot configuration was the best overall configuration at x/H of 1.0 for S/H of 0.75

Fluid mechanics of nodal flow due to embryonic primary cilia

Breaking of left–right symmetry is crucial in vertebrate development. The role of cilia-driven flow has been the subject of many recent publications, but the underlying mechanisms remain controversial. At approximately 8 days post-fertilization, after the establishment of the dorsal–ventral and anterior–posterior axes, a depressed structure is found on the ventral side of mouse embryos, termed the ventral node. Within the node, ‘whirling’ primary cilia, tilted towards the posterior, drive a flow implicated in the initial left–right signalling asymmetry. However, the underlying fluid mechanics have not been fully and correctly explained until recently and accurate characterization is required in determining how the flow triggers the downstream signalling cascades. Using the approximation of resistive force theory, we show how the flow is produced and calculate the optimal configuration to cause maximum flow, showing excellent agreement with in vitro measurements and numerical simulation, and paralleling recent analogue experiments. By calculating numerical solutions of the slender body theory equations, we present time-dependent physically based fluid dynamics simulations of particle pathlines in flows generated by large arrays of beating cilia, showing the far-field radial streamlines predicted by the theory

Mathematical modelling of cilia driven transport of biological fluids

Cilia-driven flow occurs in the airway surface liquid, in the female and male reproductive tracts and enables symmetry-breaking in the embryonic node. Viscoelastic rheology is found in healthy states in some systems, whereas in others may characterise disease, motivating the development of mathematical models that take this effect into account. We derive the fundamental solution for linear viscoelastic flow, which is subsequently used as a basis for slender-body theory. Our numerical algorithm allows efficient computation of three-dimensional time-dependent flow, bending moments, power and particle transport. We apply the model to the large-amplitude motion of a single cilium in a linear Maxwell liquid. A relatively short relaxation time of just 0.032 times the beat period significantly reduces forces, bending moments, power and particle transport, the last variable exhibiting exponential decay with relaxation time. A test particle is propelled approximately one-fifth as quickly along the direction of cilia beating for scaled relaxation time 0.032 as in the Newtonian case, and mean volume flow is abolished, emphasizing the sensitivity of cilia function to fluid rheology. These results may have implications for flow in the airways, where the transition from Newtonian to viscoelastic rheology in the peri-ciliary fluid may reduce clearance

Multichannel operation of an integrated acousto-optic wavelength routing switch for WDM systems

Polarization independent acousto-optic tunable filters (PIAOTF's) can operate as transparent wavelength-selective crossconnects to route signals in wavelength division multiplexed optical networks. In this paper, a new low power PIAOTF is characterized as a switch in multiwavelength operation, using four equally spaced lightwave signals with wavelengths between 1546 nm and 1558 nm. Interchannel interference due to sidelobe excitation is lower than -11 dB for single wavelength switching and is equal to -6 dB in the extreme case of simultaneous switching of all wavelength channels. Sources of interport and interchannel crosstalk for single and multiple wavelength switching are identified

Analytical study of catalytic reactors for hydrazine decomposition. One and two dimensional steady-state programs, computer programs manual

Programs manual for one-dimensional and two- dimensional steady state models of catalyzed hydrazine decomposition reaction chamber

Measurements of the surface energy budget in the southern Gobi Desert of China, and in the Rocky Mountains of Colorado

Observations of the land surface energy balance were made in the Gobi desert and at two mountain sites in northern Colorado. The Gobi study included 12 days of observations in spring (April 8 to 20, 1984) and 31 days in summer at the same site (June 17 to July 18, 1984). The Colorado study included 126 days (March 13 to July 17, 1984) at a valley site and 34 days (July 31 to September 3, 1984) at a mountain top location. The data for each study included continuous observations of upward and downward radiative fluxes in three wave bands, soil temperature and moisture at four levels, air temperature and humidity at four levels and UVW wind components at three levels. Analyses of the Gobi data include definition of the impact of variable atmospheric moisture on the surface energy balance between spring and summer. In addition, diurnal wind circulations forced by heating of the northern edge of the Tibetan Plateau were observed during both periods

CFD mixing analysis of axially opposed rows of jets injected into confined crossflow

A computational fluid dynamics (CFD) parametric study was performed to analyze axially opposed rows of jets mixing with crossflow in a rectangular duct. Isothermal analysis was conducted to determine the influence of lateral geometric arrangement on mixing. Two lateral arrangements were analyzed: (1) inline (jets' centerlines aligned with each other on top and bottom walls), and (2) staggered (jets' centerlines offset with each other on top and bottom walls). For a jet-to-mainstream mass flow ratio (MR) of 2.0, design parameters were systematically varied for jet-to-mainstream momentum-flux ratios (J) between 16 and 64 and orifice spacing-to-duct height ratios (S/H) between 0.125 and 1.5. Comparisons were made between geometries optimized for S/H at a specified J. Inline configurations had a unique spacing for best mixing at a specified J. In contrast, staggered configurations had two 'good mixing' spacings for each J, one corresponding to optimum inline spacing and the other corresponding to optimum non-impinging jet spacing. The inline configurations, due to their smaller orifice size at optimum S/H, produced better initial mixing characteristics. At downstream locations (e.g. x/H of 1.5), the optimum non-impinging staggered configuration produced better mixing than the optimum inline configuration for J of 64; the opposite results were observed for J of 16. Increasing J resulted in better mixing characteristics if each configuration was optimized with respect to orifice spacing. Mixing performance was shown to be similar to results from previous dilution jet mixing investigations (MR less than 0.5)