A Topos Perspective on State-Vector Reduction

A preliminary investigation is made of possible applications in quantum theory of the topos formed by the collection of all $M$-sets, where $M$ is a monoid. Earlier results on topos aspects of quantum theory can be rederived in this way. However, the formalism also suggests a new way of constructing a `neo-realist' interpretation of quantum theory in which the truth values of propositions are determined by the actions of the monoid of strings of finite projection operators. By these means, a novel topos perspective is gained on the concept of state-vector reduction

Large Space Systems Technology, volume 1

Significant and/or controversial issues related to the design, packaging, transportation, deployment, erection, and on orbit assembly of large space structures and related systems are addressed. Topics cover mission requirements, structural concepts, materials, structural alignment, thermal control, metrology, and technological forecasting

Pelletizing

DURING the last 15 or 20 years we have witnessed an extra-ordinary increase in the quantity of artificial agglomera-tes used in blast-furnace burdens. This expansion has occurred in two fields, the first being sintering, a technique applied particularly to the agglomeration of low grade 'earthy' ores and to screenings from high quality Jump

Concepts for manned lunar habitats

The design philosophy that will guide the design of early lunar habitats will be based on a compromise between the desired capabilities of the base and the economics of its development and implantation. Preferred design will be simple, make use of existing technologies, require the least amount of lunar surface preparation, and minimize crew activity. Three concepts for an initial habitat supporting a crew of four for 28 to 30 days are proposed. Two of these are based on using Space Station Freedom structural elements modified for use in a lunar-gravity environment. A third concept is proposed that is based on an earlier technology based on expandable modules. The expandable modules offer significant advantages in launch mass and packaged volume reductions. It appears feasible to design a transport spacecraft lander that, once landed, can serve as a habitat and a stand-off for supporting a regolith environmental shield. A permanent lunar base habitat supporting a crew of twelve for an indefinite period can be evolved by using multiple initial habitats. There appears to be no compelling need for an entirely different structure of larger volume and increased complexity of implantation

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

Dysregulation of insulin signaling pathway with reduced downstream neuronal survival and plasticity mechanisms is a fundamental abnormality observed in Alzheimer's disease (AD) brain. This phenomenon, known as brain insulin resistance, is associated with poor cognitive performance and is driven by the uncoupling of insulin receptor (IR) from its direct substrate (IRS1). Considering that Down syndrome (DS) and AD neuropathology share many common features, we investigated metabolic aspects of neurodegeneration, i.e., brain insulin resistance, in DS and whether it would contribute to early onset AD in DS population. Changes of levels and activation of main brain proteins belonging to the insulin signaling pathway (i.e., IR, IRS1, PTEN, GSK3β, PKCζ, AS160, GLUT4) were evaluated. Furthermore, we analyzed whether changes of these proteins were associated with alterations of: (i) proteins regulating brain energy metabolism; (ii) APP cleavage; and (ii) regulation of synaptic plasticity mechanisms in post-mortem brain samples collected from people with DS before and after the development of AD pathology (DSAD) compared with their age-matched controls. We found that DS cases were characterized by key markers of brain insulin resistance (reduced IR and increased IRS1 inhibition) early in life. Furthermore, downstream from IRS1, an overall uncoupling among the proteins of insulin signaling was observed. Dysregulated brain insulin signaling was associated with reduced hexokinase II (HKII) levels and proteins associated with mitochondrial complexes levels as well as with reduced levels of syntaxin in DS cases. Tellingly, these alterations precede the development of AD neuropathology and clinical presentations in DS. We propose that markers of brain insulin resistance rise earlier with age in DS compared with the general population and may contribute to the cognitive impairment associated with the early development of AD in DS

Time asymmetries in quantum cosmology and the searching for boundary conditions to the Wheeler-DeWitt equation

The paper addresses the quantization of minisuperspace cosmological models by studying a possible solution to the problem of time and time asymmetries in quantum cosmology. Since General Relativity does not have a privileged time variable of the newtonian type, it is necessary, in order to have a dynamical evolution, to select a physical clock. This choice yields, in the proposed approach, to the breaking of the so called clock-reversal invariance of the theory which is clearly distinguished from the well known motion-reversal invariance of both classical and quantum mechanics. In the light of this new perspective, the problem of imposing proper boundary conditions on the space of solutions of the Wheeler-DeWitt equation is reformulated. The symmetry-breaking formalism of previous papers is analyzed and a clarification of it is proposed in order to satisfy the requirements of the new interpretation.Comment: 25 pages, 1 figur