On Semi-Periods

The periods of the three-form on a Calabi-Yau manifold are found as solutions of the Picard-Fuchs equations; however, the toric varietal method leads to a generalized hypergeometric system of equations which has more solutions than just the periods. This same extended set of equations can be derived from symmetry considerations. Semi-periods are solutions of this extended system. They are obtained by integration of the three-form over chains; these chains can be used to construct cycles which, when integrated over, give periods. In simple examples we are able to obtain the complete set of solutions for the extended system. We also conjecture that a certain modification of the method will generate the full space of solutions in general.Comment: 18 pages, plain TeX. Revised derivation of $\Delta^*$ system of equations; version to appear in Nuclear Physics

Memory Effects and Scaling Laws in Slowly Driven Systems

This article deals with dynamical systems depending on a slowly varying parameter. We present several physical examples illustrating memory effects, such as metastability and hysteresis, which frequently appear in these systems. A mathematical theory is outlined, which allows to show existence of hysteresis cycles, and determine related scaling laws.Comment: 28 pages (AMS-LaTeX), 18 PS figure

Metastability in Interacting Nonlinear Stochastic Differential Equations II: Large-N Behaviour

We consider the dynamics of a periodic chain of N coupled overdamped particles under the influence of noise, in the limit of large N. Each particle is subjected to a bistable local potential, to a linear coupling with its nearest neighbours, and to an independent source of white noise. For strong coupling (of the order N^2), the system synchronises, in the sense that all oscillators assume almost the same position in their respective local potential most of the time. In a previous paper, we showed that the transition from strong to weak coupling involves a sequence of symmetry-breaking bifurcations of the system's stationary configurations, and analysed in particular the behaviour for coupling intensities slightly below the synchronisation threshold, for arbitrary N. Here we describe the behaviour for any positive coupling intensity \gamma of order N^2, provided the particle number N is sufficiently large (as a function of \gamma/N^2). In particular, we determine the transition time between synchronised states, as well as the shape of the "critical droplet", to leading order in 1/N. Our techniques involve the control of the exact number of periodic orbits of a near-integrable twist map, allowing us to give a detailed description of the system's potential landscape, in which the metastable behaviour is encoded

On Periods for String Compactifications

Motivated by recent developments in the computation of periods for string compactifications with $c=9$, we develop a complementary method which also produces a convenient basis for related calculations. The models are realized as Calabi--Yau hypersurfaces in weighted projective spaces of dimension four or as Landau-Ginzburg vacua. The calculation reproduces known results and also allows a treatment of Landau--Ginzburg orbifolds with more than five fields.Comment: HUPAPP-93/6, IASSNS-HEP-93/80, UTTG-27-93. 21 pages,harvma

Spacetime structure of the global vortex

We analyse the spacetime structure of the global vortex and its maximal analytic extension in an arbitrary number of spacetime dimensions. We find that the vortex compactifies space on the scale of the Hubble expansion of its worldvolume, in a manner reminiscent of that of the domain wall. We calculate the effective volume of this compactification and remark on its relevance to hierarchy resolution with extra dimensions. We also consider strongly gravitating vortices and derive bounds on the existence of a global vortex solution.Comment: 19 pages revtex, 2 figures, minor changes, references adde

Mechanics of universal horizons

Modified gravity models such as Ho\v{r}ava-Lifshitz gravity or Einstein-{\ae}ther theory violate local Lorentz invariance and therefore destroy the notion of a universal light cone. Despite this, in the infrared limit both models above possess static, spherically symmetric solutions with "universal horizons" - hypersurfaces that are causal boundaries between an interior region and asymptotic spatial infinity. In other words, there still exist black hole solutions. We construct a Smarr formula (the relationship between the total energy of the spacetime and the area of the horizon) for such a horizon in Einstein-{\ae}ther theory. We further show that a slightly modified first law of black hole mechanics still holds with the relevant area now a cross-section of the universal horizon. We construct new analytic solutions for certain Einstein-{\ae}ther Lagrangians and illustrate how our results work in these exact cases. Our results suggest that holography may be extended to these theories despite the very different causal structure as long as the universal horizon remains the unique causal boundary when matter fields are added.Comment: Minor clarifications. References update

Relating the Cosmological Constant and Supersymmetry Breaking in Warped Compactifications of IIB String Theory

It has been suggested that the observed value of the cosmological constant is related to the supersymmetry breaking scale M_{susy} through the formula Lambda \sim M_p^4 (M_{susy}/M_p)^8. We point out that a similar relation naturally arises in the codimension two solutions of warped space-time varying compactifications of string theory in which non-isotropic stringy moduli induce a small but positive cosmological constant.Comment: 7 pages, LaTeX, references added and minor changes made, (v3) map between deSitter and global cosmic brane solutions clarified, supersymmetry breaking discussion improved and references adde

Inhibition of Nuclear Factor of Activated T-Cells (NFAT) Suppresses Accelerated Atherosclerosis in Diabetic Mice

OBJECTIVE OF THE STUDY: Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis. METHODOLOGY AND PRINCIPAL FINDINGS: Streptozotocin (STZ)-induced diabetes in apolipoprotein E(-/-) mice resulted in 2.2 fold increased aortic atherosclerosis and enhanced pro-inflammatory burden, as evidenced by elevated blood monocytes, endothelial activation- and inflammatory markers in aorta, and pro-inflammatory cytokines in plasma. In vivo treatment with the NFAT blocker A-285222 for 4 weeks completely inhibited the diabetes-induced aggravation of atherosclerosis, having no effect in non-diabetic mice. STZ-treated mice exhibited hyperglycemia and higher plasma cholesterol and triglycerides, but these were unaffected by A-285222. NFAT-dependent transcriptional activity was examined in aorta, spleen, thymus, brain, heart, liver and kidney, but only augmented in the aorta of diabetic mice. A-285222 completely blocked this diabetes-driven NFAT activation, but had no impact on the other organs or on splenocyte proliferation or cytokine secretion, ruling out systemic immunosuppression as the mechanism behind reduced atherosclerosis. Instead, NFAT inhibition effectively reduced IL-6, osteopontin, monocyte chemotactic protein 1, intercellular adhesion molecule 1, CD68 and tissue factor expression in the arterial wall and lowered plasma IL-6 in diabetic mice. CONCLUSIONS: Targeting NFAT signaling may be a novel and attractive approach for the treatment of diabetic macrovascular complications

Quasi-realistic heterotic-string models with vanishing one-loop cosmological constant and perturbatively broken supersymmetry?

Quasi-realistic string models in the free fermionic formulation typically contain an anomalous U(1), which gives rise to a Fayet-Iliopoulos D-term that breaks supersymmetry at the one--loop level in string perturbation theory. Supersymmetry is traditionally restored by imposing F- and D-flatness on the vacuum. By employing the standard analysis of flat directions we present a quasi--realistic three generation string model in which stringent F- and D-flat solution do not appear to exist to all orders in the superpotential. We speculate that this result is indicative of the non-existence of supersymmetric flat F- and D-solutions in this model. We provide some arguments in support of this scenario and discuss its potential implications. Bose-Fermi degeneracy of the string spectrum implies that the one--loop partition function and hence the one-loop cosmological constant vanishes in the model. If our assertion is correct, this model may represent the first known example with vanishing cosmological constant and perturbatively broken supersymmetry. We discuss the distinctive properties of the internal free fermion boundary conditions that may correspond to a large set of models that share these properties. The geometrical moduli in this class of models are fixed due to asymmetric boundary conditions, whereas absence of supersymmetric flat directions would imply that the supersymmetric moduli are fixed as well and the dilaton may be fixed by hidden sector nonperturbative effects.Comment: 37 pages, LaTeX. Added discussion on stringent flat directions. PRD published versio