10,984 research outputs found
Enhance synchronizability via age-based coupling
In this brief report, we study the synchronization of growing scale-free
networks. An asymmetrical age-based coupling method is proposed with only one
free parameter . Although the coupling matrix is asymmetric, our
coupling method could guarantee that all the eigenvalues are non-negative
reals. The eigneratio R will approach to 1 in the large limit of .Comment: 3 pages, 1 figur
Labile trace elements in lunar meteorite Yamato-86032
Contents of siderophile Au, Co and Sb, mobile Ag, Bi, Cd, In, Se, Te, Tl and Zn and lithophile Cs, Ga, Rb and U were determined by RNAA in samples of the lunar meteorite (anorthositic breccia) Yamato (Y)-86032. Contents of the 4 lithophiles in matrix (, 75AM) and anorthositic clast (, 101AC) are similar to those in samples of the other 3 lunar meteorites. This is consistent with all these anorthositic breccias being from the lunar highlands. Contents of the other 11 elements indicate a micrometeorite component of 2.5±1.1% (Cl-equivalent) in the parent regolith of Y-86032,75AM. This value is unusual for lunar samples and is virtually identical to the value for the paired samples Y-82192/3 found in the same bare ice region, suggesting that these 3 specimens derive from the same lunar region in the same impact. No micrometeorite component is detectable in Y-86032,101AC. Slight compositional differences between Y-82192/3 and Y-86032 indicate that they did not travel Earthward as a single rock. Allan Hills-81005 and Y-791197 each exhibit characteristic siderophile/mobile element patterns indicating deviation from different parent regions in separate events. Hence, the 5 lunar meteorites studied thus far derive from 3 distinct impacts
Entanglement conditions for multi-mode states
We provide a class of inequalities for detecting entanglements in multi-mode
systems. Necessary conditions for fully separable, bi-separable and sufficient
conditions for fully entangled states are explicitly presented.Comment: 12 page
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A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins. MinK governs ion channel activation, regulation by second messengers, and the function and structure of the ion conduction pathway. Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the slow cardiac repolarization current (I[Ks]). HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]). These two potassium currents, I(Ks) and I(Kr), provide the principal repolarizing currents in cardiac myocytes for the termination of action potentials. Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression. Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity. MinK, through the formation of heteromeric channel complexes, is thus central to the control of the heart rate and rhythm
Collapses and revivals of exciton emission in a semiconductor microcavity: detuning and phase-space filling effects
We investigate exciton emission of quantum well embedded in a semiconductor
microcavity. The analytical expressions of the light intensity for the cases of
excitonic number state and coherent state are presented by using secular
approximation. Our results show that the effective exciton-exciton interaction
leads to the appearance of collapse and revival of the light intensity. The
revival time is twice compared the coherent state case with that of the number
state. The dissipation of the exciton-polariton lowers the revival amplitude
but does not alter the revival time. The influences of the detuning and the
phase-space filling are studied. We find that the effect of the higher-order
exciton-photon interaction may be removed by adjusting the detuning.Comment: 7 pages, 3 figure
The spontaneous emergence of ordered phases in crumpled sheets
X-ray tomography is performed to acquire 3D images of crumpled aluminum
foils. We develop an algorithm to trace out the labyrinthian paths in the three
perpendicular cross sections of the data matrices. The tangent-tangent
correlation function along each path is found to decay exponentially with an
effective persistence length that shortens as the crumpled ball becomes more
compact. In the mean time, we observed ordered domains near the crust, similar
to the lamellae phase mixed by the amorphous portion in lyotropic liquid
crystals. The size and density of these domains grow with further compaction,
and their orientation favors either perpendicular or parallel to the radial
direction. Ordering is also identified near the core with an arbitrary
orientation, exemplary of the spontaneous symmetry breaking
The Feasibility of Imaging Myocardial Ischemic/Reperfusion Injury Using \u3csup\u3e99m\u3c/sup\u3eTc-labeled Duramycin in a Porcine Model
When pathologically externalized, phosphatidylethanolamine (PE) is a potential surrogate marker for detecting tissue injuries. 99mTc-labeled duramycin is a peptide-based imaging agent that binds PE with high affinity and specificity. The goal of the current study was to investigate the clearance kinetics of 99mTc-labeled duramycin in a large animal model (normal pigs) and to assess its uptake in the heart using a pig model of myocardial ischemia–reperfusion injury.
Methods
The clearance and distribution of intravenously injected 99mTc-duramycin were characterized in sham-operated animals (n = 5). In a closed chest model of myocardial ischemia, coronary occlusion was induced by balloon angioplasty (n = 9). 99mTc-duramycin (10–15 mCi) was injected intravenously at 1 hour after reperfusion. SPECT/CT was acquired at 1 and 3 hours after injection. Cardiac tissues were analyzed for changes associated with acute cellular injuries. Autoradiography and gamma counting were used to determine radioactivity uptake. For the remaining animals, 99mTc-tetrafosamin scan was performed on the second day to identify the infarct site.
Results
Intravenously injected 99mTc-duramycin cleared from circulation predominantly via the renal/urinary tract with an α-phase half-life of 3.6 ± 0.3 minutes and β-phase half-life of 179.9 ± 64.7 minutes. In control animals, the ratios between normal heart and lung were 1.76 ± 0.21, 1.66 ± 0.22, 1.50 ± 0.20 and 1.75 ± 0.31 at 0.5, 1, 2 and 3 hours post-injection, respectively. The ratios between normal heart and liver were 0.88 ± 0.13, 0.80 ± 0.13, 0.82 ± 0.19 and 0.88 ± 0.14. In vivo visualization of focal radioactivity uptake in the ischemic heart was attainable as early as 30 min post-injection. The in vivo ischemic-to-normal uptake ratios were 3.57 ± 0.74 and 3.69 ± 0.91 at 1 and 3 hours post-injection, respectively. Ischemic-to-lung ratios were 4.89 ± 0.85 and 4.93 ± 0.57; and ischemic-to-liver ratios were 2.05 ± 0.30 to 3.23 ± 0.78. The size of 99mTc-duramycin positive myocardium was qualitatively larger than the infarct size delineated by the perfusion defect in 99mTc-tetrafosmin uptake. This was consistent with findings from tissue analysis and autoradiography.
Conclusion
99mTc-duramycin was demonstrated, in a large animal model, to have suitable clearance and biodistribution profiles for imaging. The agent has an avid target uptake and a fast background clearance. It is appropriate for imaging myocardial injury induced by ischemia/reperfusion
Learning to Rank Question Answer Pairs with Holographic Dual LSTM Architecture
We describe a new deep learning architecture for learning to rank question
answer pairs. Our approach extends the long short-term memory (LSTM) network
with holographic composition to model the relationship between question and
answer representations. As opposed to the neural tensor layer that has been
adopted recently, the holographic composition provides the benefits of scalable
and rich representational learning approach without incurring huge parameter
costs. Overall, we present Holographic Dual LSTM (HD-LSTM), a unified
architecture for both deep sentence modeling and semantic matching.
Essentially, our model is trained end-to-end whereby the parameters of the LSTM
are optimized in a way that best explains the correlation between question and
answer representations. In addition, our proposed deep learning architecture
requires no extensive feature engineering. Via extensive experiments, we show
that HD-LSTM outperforms many other neural architectures on two popular
benchmark QA datasets. Empirical studies confirm the effectiveness of
holographic composition over the neural tensor layer.Comment: SIGIR 2017 Full Pape
Optical loss compensation in a bulk left-handed metamaterial by the gain in quantum dots
A bulk left-handed metamaterial with fishnet structure is investigated to
show the optical loss compensation via surface plasmon amplification, with the
assistance of a Gaussian gain in PbS quantum dots. The optical resonance
enhancement around 200 THz is confirmed by the retrieval method. By exploring
the dependence of propagation loss on the gain coefficient and metamaterial
thickness, we verify numerically that the left-handed response can endure a
large propagation thickness with ultralow and stable loss under a certain gain
coefficient.Comment: 6 pages with 4 figure
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