Seeing bulk topological properties of band insulators in small photonic lattices

We present a general scheme for measuring the bulk properties of non-interacting tight-binding models realized in arrays of coupled photonic cavities. Specifically, we propose to implement a single unit cell of the targeted model with tunable twisted boundary conditions in order to simulate large systems and, most importantly, to access bulk topological properties experimentally. We illustrate our method by demonstrating how to measure topological invariants in a two-dimensional quantum Hall-like model.Comment: 5 pages, 2 figures; with Supplemental Material (2 pages

Topological Pumping over a Photonic Fibonacci Quasicrystal

Quasiperiodic lattices have recently been shown to be a non-trivial topological phase of matter. Charge pumping -- one of the hallmarks of topological states of matter -- was recently realized for photons in a one-dimensional (1D) off-diagonal Harper model implemented in a photonic waveguide array. The topologically nontrivial 1D Fibonacci quasicrystal (QC) is expected to facilitate a similar phenomenon, but its discrete nature and lack of pumping parameter hinder the experimental study of such topological effects. In this work we overcome these obstacles by utilizing a family of topologically equivalent QCs which ranges from the Fibonacci QC to the Harper model. Implemented in photonic waveguide arrays, we observe the topological properties of this family, and perform a topological pumping of photons across a Fibonacci QC.Comment: 5 pages, 4 figures, comments are welcom

Topological Equivalence between the Fibonacci Quasicrystal and the Harper Model

One-dimensional quasiperiodic systems, such as the Harper model and the Fibonacci quasicrystal, have long been the focus of extensive theoretical and experimental research. Recently, the Harper model was found to be topologically nontrivial. Here, we derive a general model that embodies a continuous deformation between these seemingly unrelated models. We show that this deformation does not close any bulk gaps, and thus prove that these models are in fact topologically equivalent. Remarkably, they are equivalent regardless of whether the quasiperiodicity appears as an on-site or hopping modulation. This proves that these different models share the same boundary phenomena and explains past measurements. We generalize this equivalence to any Fibonacci-like quasicrystal, i.e., a cut and project in any irrational angle.Comment: 7 pages, 2 figures, minor change

Should corifollitropin alfa be offered to patients with "genuine" poor response to controlled ovarian hyperstimulation?

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Hanbury-Brown and Twiss interference of anyons

We present a study of an Hanbury Brown and Twiss (HBT) interferometer realized with anyons. Such a device can directly probe entanglement and fractional statistics of initially uncorrelated particles. We calculate HBT cross-correlations of Abelian Laughlin anyons. The correlations we calculate exhibit partial bunching similar to bosons, indicating a substantial statistical transmuta- tion from the underlying electronic degrees of freedom. We also find qualitative differences between the anyonic signal and the corresponding bosonic or fermionic signals, indicating that anyons cannot be simply thought as intermediate between bosons and fermions.Comment: Refs adde

Topological States and Adiabatic Pumping in Quasicrystals

The unrelated discoveries of quasicrystals and topological insulators have in turn challenged prevailing paradigms in condensed-matter physics. We find a surprising connection between quasicrystals and topological phases of matter: (i) quasicrystals exhibit nontrivial topological properties and (ii) these properties are attributed to dimensions higher than that of the quasicrystal. Specifically, we show, both theoretically and experimentally, that one-dimensional quasicrystals are assigned two-dimensional Chern numbers and, respectively, exhibit topologically protected boundary states equivalent to the edge states of a two-dimensional quantum Hall system.We harness the topological nature of these states to adiabatically pump light across the quasicrystal. We generalize our results to higher-dimensional systems and other topological indices. Hence, quasicrystals offer a new platform for the study of topological phases while their topology may better explain their surface properties.Comment: 10 pages, 5 figures, 4 appendice

Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: A retrospective cohort study

INTRODUCTION: The impact of in vitro resistance on initially appropriate antibiotic therapy (IAAT) remains unclear. We elucidated the relationship between non-IAAT and mortality, and between IAAT and multi-drug resistance (MDR) in sepsis due to Gram-negative bacteremia (GNS). METHODS: We conducted a single-center retrospective cohort study of adult intensive care unit patients with bacteremia and severe sepsis/septic shock caused by a gram-negative (GN) organism. We identified the following MDR pathogens: MDR P. aeruginosa, extended spectrum beta-lactamase and carbapenemase-producing organisms. IAAT was defined as exposure within 24 hours of infection onset to antibiotics active against identified pathogens based on in vitro susceptibility testing. We derived logistic regression models to examine a) predictors of hospital mortality and b) impact of MDR on non-IAAT. Proportions are presented for categorical variables, and median values with interquartile ranges (IQR) for continuous. RESULTS: Out of 1,064 patients with GNS, 351 (29.2%) did not survive hospitalization. Non-survivors were older (66.5 (55, 73.5) versus 63 (53, 72) years, P = 0.036), sicker (Acute Physiology and Chronic Health Evaluation II (19 (15, 25) versus 16 (12, 19), P <0.001), and more likely to be on pressors (odds ratio (OR) 2.79, 95% confidence interval (CI) 2.12 to 3.68), mechanically ventilated (OR 3.06, 95% CI 2.29 to 4.10) have MDR (10.0% versus 4.0%, P <0.001) and receive non-IAAT (43.4% versus 14.6%, P <0.001). In a logistic regression model, non-IAAT was an independent predictor of hospital mortality (adjusted OR 3.87, 95% CI 2.77 to 5.41). In a separate model, MDR was strongly associated with the receipt of non-IAAT (adjusted OR 13.05, 95% CI 7.00 to 24.31). CONCLUSIONS: MDR, an important determinant of non-IAAT, is associated with a three-fold increase in the risk of hospital mortality. Given the paucity of therapies to cover GN MDRs, prevention and development of new agents are critical