Mental Illness in Early American Fiction: Charles Brockden Brown and the Sentimental Novelists

The late eighteenth and early nineteenth centuries witnessed the development of the United States of America as a new nation. This development brought with it new ideologies and social and political change; included in these changes was the way that sexual conduct outside of marriage was dealt with. Because the emerging legal system became less concerned with matters of morality, some people became frightened that sexual promiscuity would become rampant. The sentimental novel or seduction tale became a means of attempting to control sexual behavior when the law was not able to step in. The way that madness, a term used to describe a variety of mental disorders, was understood was also changing in the post-Revolutionary era. As historian Roy Porter points out, mental illness has a complex history in which it is used by society for a variety of reasons and perceptions of it have changed depending on the needs of a particular group of people. Early American culture was no different. Mental illness became something to discuss and write about, and the medical documents presented it in such a way that it fit the goals of the sentimental novelist well. Sentimental Novelists typically used mental illness and eventual death as a way to punish those characters who committed sexual misconduct. Not all novelists bought into the link between sexual misconduct and mental illness, however. Writers such as Mary Wollstonecraft and Charles Brockden Brown believed that the relationship between the two was much more complex. Charles Brockden Brown brings to life many of Wollstonecraft\u27s philosophies in his fiction and pushes very strongly for women\u27s rights using his American brand of Gothic fiction. He destabilizes the idea that sexual misconduct in and of itself could cause mental illness in three of his novels: Wieland, Ormond, and Arthur Mervyn. This thesis examines Charles Brockden Brown\u27s novels in relation to sentimental novels and shows that while he does not dispute the ability of grief and other emotions to cause mental illness, he also does not attempt to scare readers but instead uses mentally ill characters in his novels to push for social change and more rights for women

Improved profile fitting and quantification of uncertainty in experimental measurements of impurity transport coefficients using Gaussian process regression

The need to fit smooth temperature and density profiles to discrete observations is ubiquitous in plasma physics, but the prevailing techniques for this have many shortcomings that cast doubt on the statistical validity of the results. This issue is amplified in the context of validation of gyrokinetic transport models (Holland et al 2009 Phys. Plasmas 16 052301), where the strong sensitivity of the code outputs to input gradients means that inadequacies in the profile fitting technique can easily lead to an incorrect assessment of the degree of agreement with experimental measurements. In order to rectify the shortcomings of standard approaches to profile fitting, we have applied Gaussian process regression (GPR), a powerful non-parametric regression technique, to analyse an Alcator C-Mod L-mode discharge used for past gyrokinetic validation work (Howard et al 2012 Nucl. Fusion 52 063002). We show that the GPR techniques can reproduce the previous results while delivering more statistically rigorous fits and uncertainty estimates for both the value and the gradient of plasma profiles with an improved level of automation. We also discuss how the use of GPR can allow for dramatic increases in the rate of convergence of uncertainty propagation for any code that takes experimental profiles as inputs. The new GPR techniques for profile fitting and uncertainty propagation are quite useful and general, and we describe the steps to implementation in detail in this paper. These techniques have the potential to substantially improve the quality of uncertainty estimates on profile fits and the rate of convergence of uncertainty propagation, making them of great interest for wider use in fusion experiments and modelling efforts.United States. Dept. of Energy. Office of Fusion Energy Sciences (Award DE-FC02-99ER54512)United States. Dept. of Energy. Office of Science (Contract DE-AC05-06OR23177)United States. Dept. of Energy. Office of Advanced Scientific Computing Research (Award DE-SC0007099

Contrast-enhanced microCT evaluation of degeneration following partial and full width injuries to the mouse lumbar intervertebral disc

A targeted injury to the mouse intervertebral disc (IVD) is often used to recapitulate the degenerative cascade of the human pathology. Since injuries can vary in magnitude and localization, it is critical to examine the effects of different injuries on IVD degeneration. We thus evaluated the degenerative progression resulting from either a partial- or full-width injury to the mouse lumbar IVD using contrast-enhanced micro-computed tomography and histological analyses. A lateral-retroperitoneal surgical approach was used to access the lumbar IVD, and the injuries to the IVD were produced by either incising one side of the annulus fibrosus or puncturing both sides of the annulus fibrosus. Female C57BL/6J mice of 3-4 months age were used in this study. They were divided into three groups to undergo partial-width, full-width, or sham injuries. The L5/6 and L6/S1 lumbar IVDs were surgically exposed, and then the L6/S1 IVDs were injured using either a surgical scalpel (partial-width) or a 33G needle (full-width), with the L5/6 serving as an internal control. These animals recovered and then euthanized at either 2-, 4-, or 8-weeks after surgery for evaluation. The IVDs were assessed for degeneration using contrast-enhanced microCT (CEµCT) and histological analysis. The high-resolution 3D CEµCT evaluation of the IVD confirmed that the respective injuries were localized within one side of the annulus fibrosus or spanned the full width of the IVD. The full-width injury caused significant deteriorations in the nucleus pulposus, annulus fibrous and at the interfaces after 2 weeks, which was sustained through the 8 weeks, while the partial width injury caused localized disruptions that remained limited to the annulus fibrosus. The use of CEµCT revealed distinct IVD degeneration profiles resulting from partial- and full-width injuries. The partial width injury may serve as an alternative model for IVD degeneration resulting from localized annulus fibrosus injuries

Renesting Decisions and Annual Fecundity of Female Dickcissels (Spiza Americana) in Illinois

T.-Renesting decisions and annual fecundity are crucial for interpreting other demographic information, yet are infrequently reported. We used radiotelemetry to monitor female Dickcissels (Spiza americana) throughout the 1999 and 2000 breeding seasons in south- eastern Illinois. Overall fecundity (regardless of whether females remained in the study area throughout the breeding season) was 0.61 ? 0.13 female fledglings per year. Of females that re- mained within the study area, 94% fledged young (1.25 ? 0.15 female fledglings per year). Most females (62%) that experienced nest failure emigrated from the study area (moved \u3e10 km) in 2.8 ? 0.6 days; others (36%) initiated subsequent nests in 8.5 ? 0.8 days. After fledging \u3e1 young, 95% of females ceased breeding for the season. Successful and failed nest sites were indistin- guishable on the basis of vegetative characteristics. Moreover, replacement nests had similar vegetative characteristics and were similar distances from habitat edges, compared with initial nests, which suggests that female Dickcissels do not or cannot improve nest-site characteris- tics in response to nest failure. We observed two behaviors unusual in female Dickcissels: one bird that fledged two broods in one season, and the return of five females banded in 1999 to the study site in 2000

Renesting Decisions and Annual Fecundity of Female Dickcissels (Spiza americana) in Illinois

ABSTRACT.-Renesting decisions and annual fecundity are crucial for interpreting other demographic information, yet are infrequently reported. We used radiotelemetry to monitor female Dickcissels (Spiza americana) throughout the 1999 and 2000 breeding seasons in southeastern Illinois. Overall fecundity (regardless of whether females remained in the study area throughout the breeding season) was 0.61 ± 0.13 female fledglings per year. Of females that remained within the study area, 94% fledged young (1.25 ± 0.15 female fledglings per year). Most females (62%) that experienced nest failure emigrated from the study area (moved \u3e10 km) in 2.8 ± 0.6 days; others (36%) initiated subsequent nests in 8.5 ± 0.8 days. After fledging ~1 young, 95% of females ceased breeding for the season. Successful and failed nest sites were indistinguishable on the basis of vegetative characteristics. Moreover, replacement nests had similar vegetative characteristics and were similar distances from habitat edges, compared with initial nests, which suggests that female Dickcissels do not or cannot improve nest-site characteristics in response to nest failure. We observed two behaviors unusual in female Dickcissels: one bird that fledged two broods in one season, and the return of five females banded in 1999 to the study site in 2000

Renesting Decisions and Annual Fecundity of Female Dickcissels (Spiza Americana) in Illinois

T.-Renesting decisions and annual fecundity are crucial for interpreting other demographic information, yet are infrequently reported. We used radiotelemetry to monitor female Dickcissels (Spiza americana) throughout the 1999 and 2000 breeding seasons in south- eastern Illinois. Overall fecundity (regardless of whether females remained in the study area throughout the breeding season) was 0.61 ? 0.13 female fledglings per year. Of females that re- mained within the study area, 94% fledged young (1.25 ? 0.15 female fledglings per year). Most females (62%) that experienced nest failure emigrated from the study area (moved \u3e10 km) in 2.8 ? 0.6 days; others (36%) initiated subsequent nests in 8.5 ? 0.8 days. After fledging \u3e1 young, 95% of females ceased breeding for the season. Successful and failed nest sites were indistin- guishable on the basis of vegetative characteristics. Moreover, replacement nests had similar vegetative characteristics and were similar distances from habitat edges, compared with initial nests, which suggests that female Dickcissels do not or cannot improve nest-site characteris- tics in response to nest failure. We observed two behaviors unusual in female Dickcissels: one bird that fledged two broods in one season, and the return of five females banded in 1999 to the study site in 2000

Renesting Decisions and Annual Fecundity of Female Dickcissels (Spiza americana) in Illinois

ABSTRACT.-Renesting decisions and annual fecundity are crucial for interpreting other demographic information, yet are infrequently reported. We used radiotelemetry to monitor female Dickcissels (Spiza americana) throughout the 1999 and 2000 breeding seasons in southeastern Illinois. Overall fecundity (regardless of whether females remained in the study area throughout the breeding season) was 0.61 ± 0.13 female fledglings per year. Of females that remained within the study area, 94% fledged young (1.25 ± 0.15 female fledglings per year). Most females (62%) that experienced nest failure emigrated from the study area (moved \u3e10 km) in 2.8 ± 0.6 days; others (36%) initiated subsequent nests in 8.5 ± 0.8 days. After fledging ~1 young, 95% of females ceased breeding for the season. Successful and failed nest sites were indistinguishable on the basis of vegetative characteristics. Moreover, replacement nests had similar vegetative characteristics and were similar distances from habitat edges, compared with initial nests, which suggests that female Dickcissels do not or cannot improve nest-site characteristics in response to nest failure. We observed two behaviors unusual in female Dickcissels: one bird that fledged two broods in one season, and the return of five females banded in 1999 to the study site in 2000

Six Blind Men and One Elephant – Proposing an Integrative Framework to Advance Research and Practice in Justice Philanthropy

There are growing calls that philanthropic foundations across the globe can and should advance diversity, equity, inclusion, and justice. Initial evidence indicates that foundations have indeed responded as evidenced by pledges to change practice, increased funding for racial justice, and the emergence of new networks to support equity and justice. However, there is also great skepticism about whether the field of foundations are, in fact, able to make lasting changes given numerous critiques of philanthropy and its structural limitations. In this article, we summarize these critiques that suggest factors that make institutional philanthropy resistant to calls for equity and justice. We posit that a core obstacle is a lack of conceptual coherence within and across academic and practitioner literature about the meanings of terms and their implications for practice. Therefore, we propose a transdisciplinary conceptual framework of justice philanthropy that integrates the fragmented literature on justice-related aspects of philanthropy emerging from different disciplinary traditions such as ethics, political theory and political science, social movement theory, geography, public administration, and community development