Glycaemic response of four mango fruits consumed in Enugu State

Background: Mango fruit is a delicious juicy drupe, commonly consumed in Nigeria. It is a seasonal fruits that is consumed by all. However, diabetic patients sometimes are afraid of spike in their blood sugar after consuming fruits of which mango is one of them. Evidenced based dietary counselling and nutrition eduction of the public requires such an empirical study to establish evidence. Objectives: This study examined the glycemic response, glycemic index and glycemic load of four mango fruits consumed in Nsukka, Enugu state. Methodology: Samples of four mango varieties (Opioro, Alphonso, Haden, and Sweet) were randomly selected from different markets in Nsukka, Enugu state, Nigeria. These samples were thoroughly washed in warm water to remove gums. The edible portion of the mango (alphonso, haden and sweet mango was consumed with the peels, while the peel of opioro mango was remove before consumption). The weight of each variety that will give about 25g available carbohydrate was used as the test meal. Voluntary human subjects who were informed about the research were used and withdrawal at any stage was allowed. Ethical approval given by Research Ethics Committee University of Nigeria Teaching Hospital Ituku-Ozalla. Available carbohydrate was determined using standard method. The glycemic response was done using the FAO protocols. Descriptive statistics (mean and standard deviation) was used to present the data obtained while analysis of variance (ANOVA) was used to compare the means and turkey HSD test was used to separate the means. Results: Available carbohydrate was highest in Sweet mango (6.18g). Alphonso mango significantly (p<0.05) had the least effect on blood glucose levels. The glycemic index of the samples was 33 for Opioro, 4 for Alphonso, 15 for Haden and 39 for Sweet mangoes. The glycemic load ranged from 5.18 in Haden mango to 6.18 in Sweet mango. Conclusion: The study revealed that Alphonso mangoes could be used in planning diets for people with metabolic diseases like diabetes mellitus

Stress Among Parents of Hospitalized Infants in NICU: Effects on Parental Needs and Expectations

Abstract. Neonatal Intensive Care Unit (NICU) environment has the potential to exacerbate stress for parents of infants admitted to the unit. This study investigated the stress among parents of hospitalized infants in neonatal intensive care unit, and its effects on parental needs and expectations. Convenient sampling method was used to select 216 parents of at-risk infants in the NICU from two Teaching Hospitals in the South-East Zone of Nigeria. Two research questions and three null hypotheses guided the study. Parental Stressor Scale: Neonatal Intensive Care Unit and Parental Self -report Scale on coping measures were used to measure the stress among the parents. A parent -infant demographic information was obtained and used to determine the extent to which the characteristics serve as stress predictors. Mean score, standard deviation (SD) and Spearman Rank correlation Coefficient (rho) were used to answer the research questions while Chi-square, Wilcoxon and Mann-Whitney U tests were adopted in testing the null hypotheses at 0.01 level of significance. Parental stress for NICU infant behaviour and appearance significantly correlated with parental role alteration while infant gestational age correlated with parental stress for NICU staff behaviour and communication. Significant differences resulted in parental self-report of coping measures and their role alterations with regard to number of children born by parents and across the fertility history of the parents respectively. Parents of infants in the NICU need to take more active part in decision making and care of their infants

Model for stimulating entrepreneurial skills through entrepreneurship education in an African context

The need to stimulate entrepreneurial skills in graduates as a strategy for tackling graduate unemployment has spurred the introduction of entrepreneurship education programs. The effectiveness of such entrepreneurship education programs from an African context is the focus of this paper. A modified model for evaluating the effectiveness of entrepreneurship education was derived from Fayolle, Gaily, and Lassa-Clerc; and was tested via structural equation modeling. Data were collected from randomly selected 750 participants who had undergone at least one compulsory entrepreneurship module at the university level. It was found that entrepreneurship education which is not well aligned with contextual peculiarities may not optimally yield the desired outcome. This paper, therefore, underscores the need for a thoroughly contextualized curriculum that encapsulates national, local, and very importantly, institutional factors

Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria.

Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emergence and spread of the SARS-CoV-2 B.1.1.318 and B.1.525 (Eta) variants of interest in Nigeria and the wider Africa region. By integrating travel data and phylogeographic reconstructions, we find that these two variants that arose during the second wave in Nigeria emerged from within Africa, with the B.1.525 from Nigeria, and then spread to other parts of the world. Data from this study show how regional connectivity of Nigeria drove the spread of these variants of interest to surrounding countries and those connected by air-traffic. Our findings demonstrate the power of genomic analysis when combined with mobility and epidemiological data to identify the drivers of transmission, as bidirectional transmission within and between African nations are grossly underestimated as seen in our import risk index estimates

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.

Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and illuminate the distinct dispersal dynamics of variants of concern-particularly Alpha, Beta, Delta, and Omicron-on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve while the continent faces many emerging and reemerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Adverse reactions to blood donation: A descriptive study of 3520 blood donors in a Nigerian tertiary hospital

Background: The occurrence of adverse reactions to blood donation significantly hampers donor retention and negatively impacts on the universal availability of adequate numbers of blood donor units. Objective: To analyze the spectrum and prevalence of adverse reactions in blood donors in a tertiary hospital-based blood bank in Nigeria. Subjects and Methods: The details of 3520 blood donors who presented for donation over a 12 months period were retrieved from the departmental archives for analysis. These included sociodemographic information, type of donor, type and frequency of adverse reactions to blood donation. Data were analyzed using the Statistical Package for Social Sciences version 20.0 (SPSS Inc., Chicago, IL, USA) computer software. Descriptive and inferential statistics were employed to represent the distribution of donor characteristics (as percentages) and compare reaction rates by gender and severity, respectively. Results: The prevalence of adverse reactions to blood donation was (56/3520) 1.60%; this occurred more frequently in male and family replacement donors (55.35% and 100.0%, respectively). The spectrum of donor adverse reactions included anxiety 25 (44.64%), generalized body weakness 11 (19.64%), hematoma 10 (17.86%), fainting 5 (8.93%), and vomiting 5 (8.93%). Vasovagal reactions were the most frequent adverse reaction encountered among the donors (46/56; 82.14%). Conclusion: Vasovagal reactions are common adverse phenomena in our blood donor set; this has implications on transfusion safety and blood donor retention

Adverse reactions to blood donation: A descriptive study of 3520 blood donors in a Nigerian tertiary hospital

Background: The occurrence of adverse reactions to blood donation significantly hampers donor retention and negatively impacts on the universal availability of adequate numbers of blood donor units. Objective: To analyze the spectrum and prevalence of adverse reactions in blood donors in a tertiary hospital-based blood bank in Nigeria. Subjects and Methods: The details of 3520 blood donors who presented for donation over a 12 months period were retrieved from the departmental archives for analysis. These included sociodemographic information, type of donor, type and frequency of adverse reactions to blood donation. Data were analyzed using the Statistical Package for Social Sciences version 20.0 (SPSS Inc., Chicago, IL, USA) computer software. Descriptive and inferential statistics were employed to represent the distribution of donor characteristics (as percentages) and compare reaction rates by gender and severity, respectively. Results: The prevalence of adverse reactions to blood donation was (56/3520) 1.60%; this occurred more frequently in male and family replacement donors (55.35% and 100.0%, respectively). The spectrum of donor adverse reactions included anxiety 25 (44.64%), generalized body weakness 11 (19.64%), hematoma 10 (17.86%), fainting 5 (8.93%), and vomiting 5 (8.93%). Vasovagal reactions were the most frequent adverse reaction encountered among the donors (46/56; 82.14%). Conclusion: Vasovagal reactions are common adverse phenomena in our blood donor set; this has implications on transfusion safety and blood donor retention