19 research outputs found
Hepatic artery pseudoaneurysm ligation after orthotopic liver transplantation-a report of 7 cases
Pseudoaneurysm (PA) is a rare but life-threatening complication of liver transplantation. The authors present their experience on 7 patients treated by ligation of a post-OLT PA. Hepatic artery ligation or embolization was performed from 10 to 70 days after liver transplantation. Of the seven patients, four survived, one developed a biliary stricture, treated by percutaneous ballon dilatation, two died of a complication not related to treatment, and one died of multiple organ failure. © 1992 by Williams & Wilkins
Hemorrhage associated with hepatic artery pseudoaneurysms after regional chemotherapy with floxuridine: case report
Pseudoaneurysms of the hepatic artery are a rare complication in patients with primary or secondary liver tumors treated with intra-arterial chemotherapy. We present two patients who developed this complication after placement of a catheter system into the gastroduodenal artery and initiation of regional chemotherapy with floxuridine. Diagnosis was made after symptomatic bleeding occurred, necessitating emergency angiography with coil embolization. Pseudoaneurysms usually occur after mechanical damage of the vessel wall, but the chemical toxicity of floxuridine may add to the development of vascular impairment
Extended adjuvant hormonal therapy with exemestane has no detrimental effect on the lipid profile of postmenopausal breast cancer patients: final results of the ATENA lipid substudy
592 Tamoxifen in combination with chemotherapy in locally advanced or metastatic breast cancer
Tamoxifen in combination with chemotherapy in locally advanced or metastatic breast cancer
Significance of bile leaks complicating conservative surgery for liver hydatidosis
Hepatic hydatidosis presents a challenge in liver surgery, and there is
still controversy regarding the appropriate surgical technique. A high
incidence of postoperative bile leaks is reported as a significant
disadvantage of conservative surgical procedures. The purpose of this
study was to examine the incidence and clinical importance of bile
leakage in patients being treated exclusively by a conservative surgical
technique. From January 1985 to November 2000 a total of 187 patients
were operated on at our department for hepatic hydatidosis. They were
subjected to the standard conservative surgical technique (wide
unroofing and cyst drainage). A total of IS complications were related
to bile leakage (10%), 3 of them bile abscesses (1 drained surgically
and 2 percutaneously), 1 case of bile peritonitis due to an accessory
bile duct in the gallbladder bed (treated surgically), and 14 fistulas
(1 bronchobiliary and 13 biliocutaneous). Five of the fistulas,
including the bronchobiliary one, were treated successfully by
endoscopy; and the remaining nine healed after conservative treatment.
Bile leakage, representing a significant complication following
conservative operations for hepatic hydatidosis, can be effectively
treated conservatively or endoscopically, not justifying more aggressive
surgical approaches
HEPATIC ARTERY PSEUDOANEURYSM LIGATION AFTER ORTHOTOPIC LIVER TRANSPLANTATION—A REPORT OF 7 CASES
Extended adjuvant hormonal therapy with exemestane has no detrimental effect on the lipid profile of postmenopausal breast cancer patients: Final results of the ATENA lipid substudy
Introduction: Extended adjuvant endocrine therapy for breast cancer with aromatase inhibitors may potentially alter the lipid profile of postmenopausal patients and thus increase the risk of developing cardiovascular disease. In this study, a subprotocol of the ATENA (Adjuvant post-Tamoxifen Exemestane versus Nothing Applied) trial, we compared the effect of the steroidal aromatase inactivator exemestane on the lipid profile of postmenopausal patients with operable breast cancer, in the adjuvant setting, with that of observation alone after completion of 5 to 7 years of primary treatment with tamoxifen.Methods: In this open-label, randomized, parallel-group study, 411 postmenopausal patients with operable breast cancer, who had been treated with tamoxifen for 5 to 7 years, were randomized to either 5 additional years of exemestane (25 mg/day; n = 211) or observation only (n = 200). Assessments of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total serum triglycerides (TRG) were performed at baseline and then during each follow-up visit, performed at either 6 or 12 months, according to the center's clinical practice, until completing 24 months in the study.Results: TC and LDL levels increased significantly across time for both arms; TC increase was more pronounced for the observation arm, and that was sustained up to 24 months. HDL levels decreased significantly across time for the exemestane arm, whereas no significant change was detected across time for the observation arm. Triglyceride levels decreased significantly across time on both arms, with no difference detected in changes from baseline between the exemestane and the observation arms.Conclusions: Exemestane lacks the beneficial effect of tamoxifen on lipids; however, sequential adjuvant treatment with exemestane in postmenopausal breast cancer patients after cessation of 5 to 7 years of tamoxifen does not appear to alter the lipid profile significantly compared with that of an observational arm.Trial Registration: ClinicalTrials.gov ID: NCT00810706. © 2009 Markopoulos et al.; Licensee BioMed Central Ltd