Center for the Study of Religion and American Culture

poster abstractThe NEH Summer Institute for Teachers will support the studies of twenty-five talented teachers from across the nation as they join with nationally renowned scholars to explore how religion has shaped, and been shaped by, the American experience. The institute directors, Philip Goff, Arthur Farnsley, and Rachel Wheeler, are all noted scholars in their field, whose work encompasses a wide range of subject matter and methodologies. The institute will enable participants from many different fields to develop new materials on American religion that can be incorporated into their current curricula. An English teacher introducing Uncle Tom’s Cabin, or The Adventures of Huckleberry Finn, for instance, will be better prepared to discuss the nexus of religion and race in the context of nineteenth-century America. A civics teacher focusing on the origins of the American government will be able to incorporate discussion about the religion of the founders and the ways in which the First Amendment has shaped American society. The prime goal of The Bible in American Life project is to gain insight for clergy and scholars on Bible-reading as a religious practice. We are particularly interested in how people use the Bible in their personal lives, how religious communities and even the internet shape individuals’ comprehension of scripture, and how individual and communal understandings of scripture influence American public life. Employing both quantitative methods (the General Social Survey and a local survey) and qualitative research (focus-group interviews, historical analysis, and other means), we hope to provide an unprecedented perspective on the Bible’s role outside the context of worship, in the lived religion of a broad cross-section of Americans both now and in the past. Such data will be invaluable to clergy and seminar professors seeking more effective ways to teach and preach scripture in an age saturated with information and technology. The results of the project also will help scholars seeking to understand recent changes in American Christianity

Evidence-Based Interventions and Strategies for the Grand Challenges Approach: The Need for Judgement

What is the value of evidence-based interventions in addressing “Grand Challenges”? Building upon the EPOS Grand Challenges work (Sakhrani et al., 2017), this paper explores whether evidence-based approaches developed for management and policy are relevant to addressing Grand Challenges. It discusses the criticisms of the Evidence-based Management approach and argues that evidence is a necessary, but not sufficient input in the decisionmaking process of addressing Grand Challenges

Applications of Film Tomography Technique for QNDE

Tomography with X- and gamma- rays provides three-dimensional radiographic information on the examined object. The film-based tomography (1,2) generates a summation-image of a surface within the object by continuously combining back projections directly on the film. This method has many attractive features for industrial applications in which cost and simplicity are of primary importance. Some of the features are: (1) The absence of post processing allows this method to yield an image immediately on development of the film.; (2) Conventional radiologists need a short training time to master the technique as most components and concepts are familiar to them: e. g. radiation sources, films, screens, collimators, filters, processing units, viewers, exposure, contrast, resolution.; (3) Purpose oriented system optimized for a certain range of products, may be built with costs much less than digital computing trans-axial tomography (CT).; (4) Tomographic images of surfaces of critical areas within the examined object are directly recorded on films curved to match the required shape.; (5) Tomographs on film may be digitized and imaged-processed by commercial system developed for conventional radiographs.; (6) The slice thickness of the recorded surface may be in the order of magnitude of the thickness of the film-emulsion.; (7) The quality of the tomograph is high especially for high- contrast objects (2) and whenever the noise and the dynamic-range of the film do not impose a limitation on the information to be extracted.</p

Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study.

Murine models suggest that the microRNAs miR-103 and miR-143 may play central roles in the regulation of subcutaneous adipose tissue (SAT) and development of type 2 diabetes (T2D). The microRNA miR-483-3p may reduce adipose tissue expandability and cause ectopic lipid accumulation, insulin resistance and T2D. We aimed to explore the genetic and non-genetic factors that regulate these microRNAs in human SAT, and to investigate their impact on metabolism in humans. Levels of miR-103, miR-143 and miR-483-3p were measured in SAT biopsies from 244 elderly monozygotic and dizygotic twins using real-time PCR. Heritability estimates were calculated and multiple regression analyses were performed to study associations between these microRNAs and measures of metabolism, as well as between these microRNAs and possible regulating factors. We found that increased BMI was associated with increased miR-103 expression levels. In addition, the miR-103 levels were positively associated with 2 h plasma glucose levels and hemoglobin A1c independently of BMI. Heritability estimates for all three microRNAs were low. In conclusion, the expression levels of miR-103, miR-143 and miR-483-3p in adipose tissue are primarily influenced by non-genetic factors, and miR-103 may be involved in the development of adiposity and control of glucose metabolism in humans

Influence of fractional flow reserve on grafts patency: Systematic review and patient-level meta-analysis.

To investigate the impact of invasive functional guidance for coronary artery bypass graft surgery (CABG) on graft failure. Data on the impact of fractional flow reserve (FFR) in guiding CABG are still limited. Systematic review and individual patient data meta-analysis were performed. Primary objective was the risk of graft failure, stratified by FFR. Risk estimates are reported as odds ratios (ORs) derived from the aggregated data using random-effects models. Individual patient data were analyzed using mixed effect model to assess relationship between FFR and graft failure. This meta-analysis is registered in PROSPERO (CRD42020180444). Four prospective studies comprising 503 patients referred for CABG, with 1471 coronaries, assessed by FFR were included. Graft status was available for 1039 conduits at median of 12.0 [IQR 6.6; 12.0] months. Risk of graft failure was higher in vessels with preserved FFR (OR 5.74, 95% CI 1.71-19.29). Every 0.10 FFR units decrease in the coronaries was associated with 56% risk reduction of graft failure (OR 0.44, 95% CI 0.34 to 0.59). FFR cut-off to predict graft failure was 0.79. Surgical grafting of coronaries with functionally nonsignificant stenoses was associated with higher risk of graft failure

Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort

OBJECTIVE Offspring of pregnancies affected by gestational diabetes mellitus (GDM) are at increased risk of the development of type 2 diabetes. However, the extent to which these dysmetabolic traits may be due to offspring and/or maternal adiposity is unknown. We examined body composition and associated cardiometabolic traits in 561 9- to 16-year-old offspring of mothers with GDM and 597 control offspring. RESEARCH DESIGN AND METHODS We measured anthropometric characteristics; puberty status; blood pressure; and fasting glucose, insulin, C-peptide, and lipid levels; and conducted a DEXA scan in a subset of the cohort. Differences in the outcomes between offspring of mothers with GDM and control subjects were examined using linear and logistic regression models. RESULTS After adjustment for age and sex, offspring of mothers with GDM displayed higher weight, BMI, waist-to-hip ratio (WHR), systolic blood pressure, and resting heart rate and lower height. Offspring of mothers with GDM had higher total and abdominal fat percentages and lower muscle mass percentages, but these differences disappeared after correction for offspring BMI. The offspring of mothers with GDM displayed higher fasting plasma glucose, insulin, C-peptide, HOMA-insulin resistance (IR), and plasma triglyceride levels, whereas fasting plasma HDL cholesterol levels were decreased. Female offspring of mothers with GDM had an earlier onset of puberty than control offspring. Offspring of mothers with GDM had significantly higher BMI, WHR, fasting glucose, and HOMA-IR levels after adjustment for maternal prepregnancy BMI, and glucose and HOMA-IR remained elevated in the offspring of mothers with GDM after correction for both maternal and offspring BMIs. CONCLUSIONS In summary, adolescent offspring of women with GDM show increased adiposity, an adverse cardiometabolic profile, and earlier onset of puberty among girls. Increased fasting glucose and HOMA-IR levels among the offspring of mothers with GDM may be explained by the programming effects of hyperglycemia in pregnancy. </jats:sec