Avaliação da qualidade de vida em pacientes cirróticos com hérnia da parede abdominal Quality of life in patients with abdominal hernia and cirrhosis

RACIONAL: As hérnias de parede abdominal são um problema frequente no paciente cirrótico. Elas costumam ser volumosas e muito sintomáticas. OBJETIVO: Avaliar a qualidade de vida, através da aplicação do questionário Short Form-36 (SF-36), nos pacientes com hérnia e cirrose. MÉTODOS: Foram avaliados 39 pacientes cirróticos com hérnia de parede abdominal estratificados pela classificação de Child e submetidos ao questionário SF-36 por um mesmo profissional. RESULTADOS: A média dos escores obtidos no SF-36 mostra diminuição em todos os domínios nos pacientes cirróticos, principalmente no aspecto físico. O grupo Child B mostrou pior avaliação ao estado geral de saúde e capacidade funcional em relação ao grupo Child A, contudo não houve diferença em relação ao aspecto físico. CONCLUSÃO: A presença de hérnia de parede abdominal ocasiona piora na qualidade de vida do paciente cirrótico. A deterioração da função hepática está relacionada a pior qualidade de vida. A hérnia abdominal leva a restrição importante no aspecto físico também no Child A.<br>BACKGROUND: Abdominal hernias are frequent issue in cirrhotic patients. These hernias tend to be large and symptomatic. AIM: To analyze the quality of life using a Short Form-36 (SF-36) questionnaire in cirrhotic patients with abdominal hernia. METHODS: Thirty nine cirrhotic patients with abdominal wall hernia were analyzed. They were stratified according to Child´s classification and answered the SF-36 questionnaire administered by a same professional. RESULTS: The scores from SF-36 show impairment in all questionnaire domains in cirrhotic patients, especially in the physical aspect. The Child B group showed worse health general condition and functional capacity comparing with Child A group; however it did not show any significant difference related to physical aspect. CONCLUSION: The presence of abdominal hernia leads to worse quality of life in cirrhotic patients. Hepatic function deterioration is related to a worse quality of life. Abdominal hernia causes an important restriction in physical aspect even in Child A

Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary Perspective

Malignant bowel obstruction (MBO) is a major complication in women with advanced gynecologic cancers which imposes a significant burden on patients, caregivers, and healthcare systems. Symptoms of MBO are challenging to palliate and result in progressive decompensation of already vulnerable patients with limited therapeutic options and a short prognosis. However, there is a paucity of guidelines or innovative approaches to improve the care of women who develop MBO. MBO is a complex clinical situation that requires a multidisciplinary approach to ensure the appropriate treatment modality and interprofessional care to optimally manage these patients. This review summarizes the current literature on the different approaches targeting MBO management including surgical intervention, chemotherapy, total parenteral nutrition, and pharmacological treatment. In addition, the impact of MBO management on patients’ quality of life (QOL) is examined. This article focuses on the challenges in developing evidence-based treatment guidelines for MBO and barriers in clinical trial design for MBO and proposes strategies to advance the MBO management. Collaboration is essential to design studies that may improve the overall care and quality of life for these patients. Prospective data are needed to inform clinical practice, establish a new benchmark for evidence-based MBO management, and better understand the biology of MBO.Peer Reviewe

Ptpn6 inhibits caspase-8-and Ripk3/Mlkl-dependent inflammation

Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1) receptor-dependent, caspase-1-independent inflammatory disease. Conditional deletion of Ptpn6 in neutrophils (Ptpn6∆PMN) is sufficient to initiate IL-1 receptor-dependent cutaneous inflammatory disease, but the source of IL-1 and the mechanisms behind IL-1 release remain unclear. Here, we investigate the mechanisms controlling IL-1α/β release from neutrophils by inhibiting caspase-8-dependent apoptosis and Ripk1-Ripk3-Mlkl-regulated necroptosis. Loss of Ripk1 accelerated disease onset, whereas combined deletion of caspase-8 and either Ripk3 or Mlkl strongly protected Ptpn6∆PMN mice. Ptpn6∆PMN neutrophils displayed increased p38 mitogen-activated protein kinase-dependent Ripk1-independent IL-1 and tumor necrosis factor production, and were prone to cell death. Together, these data emphasize dual functions for Ptpn6 in the negative regulation of p38 mitogen-activated protein kinase activation to control tumor necrosis factor and IL-1α/β expression, and in maintaining Ripk1 function to prevent caspase-8- and Ripk3-Mlkl-dependent cell death and concomitant IL-1α/β release