2,172 research outputs found
Multiple early gastric cancer with duodenal invasion
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Electronic correlation in the infrared optical properties of the quasi two dimensional -type BEDT-TTF dimer system
The polarized optical reflectance spectra of the quasi two dimensional
organic correlated electron system -(BEDT-TTF)Cu[N(CN)],
Br and Cl are measured in the infrared region. The former shows the
superconductivity at 11.6 K and the latter does the
antiferromagnetic insulator transition at 28 K. Both the
specific molecular vibration mode of the BEDT-TTF molecule and
the optical conductivity hump in the mid-infrared region change correlatively
at 38 K of -(BEDT-TTF)Cu[N(CN)]Br, although
no indication of but the insulating behaviour below 50-60 K are found in -(BEDT-TTF)Cu[N(CN)]Cl. The
results suggest that the electron-molecular vibration coupling on the
mode becomes weak due to the enhancement of the itinerant
nature of the carriers on the dimer of the BEDT-TTF molecules below ,
while it does strong below because of the localized carriers on
the dimer. These changes are in agreement with the reduction and the
enhancement of the mid-infrared conductivity hump below and , respectively, which originates from the transitions between the upper
and lower Mott-Hubbard bands. The present observations demonstrate that two
different metallic states of -(BEDT-TTF)Cu[N(CN)]Br are
regarded as {\it a correlated good metal} below including the
superconducting state and {\it a half filling bad metal} above . In
contrast the insulating state of -(BEDT-TTF)Cu[N(CN)]Cl
below is the Mott insulator.Comment: 8 pages, 7 figure
Tyrosine Sulfation of the Amino Terminus of PSGL-1 Is Critical for Enterovirus 71 Infection
Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease, a common febrile disease in children; however, EV71 has been also associated with various neurological diseases including fatal cases in large EV71 outbreaks particularly in the Asia Pacific region. Recently we identified human P-selectin glycoprotein ligand-1 (PSGL-1) as a cellular receptor for entry and replication of EV71 in leukocytes. PSGL-1 is a sialomucin expressed on the surface of leukocytes, serves as a high affinity counterreceptor for selectins, and mediates leukocyte rolling on the endothelium. The PSGL-1–P-selectin interaction requires sulfation of at least one of three clustered tyrosines and an adjacent O-glycan expressing sialyl Lewis x in an N-terminal region of PSGL-1. To elucidate the molecular basis of the PSGL-1–EV71 interaction, we generated a series of PSGL-1 mutants and identified the post-translational modifications that are critical for binding of PSGL-1 to EV71. We expressed the PSGL-1 mutants in 293T cells and the transfected cells were assayed for their abilities to bind to EV71 by flow cytometry. We found that O-glycosylation on T57, which is critical for PSGL-1–selectin interaction, is not necessary for PSGL-1 binding to EV71. On the other hand, site-directed mutagenesis at one or more potential tyrosine sulfation sites in the N-terminal region of PSGL-1 significantly impaired PSGL-1 binding to EV71. Furthermore, an inhibitor of sulfation, sodium chlorate, blocked the PSGL-1–EV71 interaction and inhibited PSGL-1-mediated viral replication of EV71 in Jurkat T cells in a dose-dependent manner. Thus, the results presented in this study reveal that tyrosine sulfation, but not O-glycosylation, in the N-terminal region of PSGL-1 may facilitate virus entry and replication of EV71 in leukocytes
Ferromagnetic Semiconductors: Moving Beyond (Ga,Mn)As
The recent development of MBE techniques for growth of III-V ferromagnetic
semiconductors has created materials with exceptional promise in spintronics,
i.e. electronics that exploit carrier spin polarization. Among the most
carefully studied of these materials is (Ga,Mn)As, in which meticulous
optimization of growth techniques has led to reproducible materials properties
and ferromagnetic transition temperatures well above 150 K. We review progress
in the understanding of this particular material and efforts to address
ferromagnetic semiconductors as a class. We then discuss proposals for how
these materials might find applications in spintronics. Finally, we propose
criteria that can be used to judge the potential utility of newly discovered
ferromagnetic semiconductors, and we suggest guidelines that may be helpful in
shaping the search for the ideal material.Comment: 37 pages, 4 figure
Thermal-equilibrium defects in undoped hydrogenated amorphous silicon, silicon-carbon, and silicon-nitrogen
Search for GeV Gamma-ray Counterparts of Gravitational Wave Events by CALET
We present results on searches for gamma-ray counterparts of the LIGO/Virgo
gravitational-wave events using CALorimetric Electron Telescope ({\sl CALET})
observations. The main instrument of {\sl CALET}, CALorimeter (CAL), observes
gamma-rays from GeV up to 10 TeV with a field of view of nearly 2 sr.
In addition, the {\sl CALET} gamma-ray burst monitor (CGBM) views 3 sr
and sr of the sky in the 7 keV -- 1 MeV and the 40 keV -- 20 MeV
bands, respectively, by using two different crystal scintillators. The {\sl
CALET} observations on the International Space Station started in October 2015,
and here we report analyses of events associated with the following
gravitational wave events: GW151226, GW170104, GW170608, GW170814 and GW170817.
Although only upper limits on gamma-ray emission are obtained, they correspond
to a luminosity of erg s in the GeV energy band
depending on the distance and the assumed time duration of each event, which is
approximately the order of luminosity of typical short gamma-ray bursts. This
implies there will be a favorable opportunity to detect high-energy gamma-ray
emission in further observations if additional gravitational wave events with
favorable geometry will occur within our field-of-view. We also show the
sensitivity of {\sl CALET} for gamma-ray transient events which is the order of
~erg\,cm\,s for an observation of 100~s duration.Comment: 12 pages, 8 figures, 1 table. Accepted for publication in
Astrophysical Journa
On-orbit Operations and Offline Data Processing of CALET onboard the ISS
The CALorimetric Electron Telescope (CALET), launched for installation on the
International Space Station (ISS) in August, 2015, has been accumulating
scientific data since October, 2015. CALET is intended to perform long-duration
observations of high-energy cosmic rays onboard the ISS. CALET directly
measures the cosmic-ray electron spectrum in the energy range of 1 GeV to 20
TeV with a 2% energy resolution above 30 GeV. In addition, the instrument can
measure the spectrum of gamma rays well into the TeV range, and the spectra of
protons and nuclei up to a PeV.
In order to operate the CALET onboard ISS, JAXA Ground Support Equipment
(JAXA-GSE) and the Waseda CALET Operations Center (WCOC) have been established.
Scientific operations using CALET are planned at WCOC, taking into account
orbital variations of geomagnetic rigidity cutoff. Scheduled command sequences
are used to control the CALET observation modes on orbit. Calibration data
acquisition by, for example, recording pedestal and penetrating particle
events, a low-energy electron trigger mode operating at high geomagnetic
latitude, a low-energy gamma-ray trigger mode operating at low geomagnetic
latitude, and an ultra heavy trigger mode, are scheduled around the ISS orbit
while maintaining maximum exposure to high-energy electrons and other
high-energy shower events by always having the high-energy trigger mode active.
The WCOC also prepares and distributes CALET flight data to collaborators in
Italy and the United States.
As of August 31, 2017, the total observation time is 689 days with a live
time fraction of the total time of approximately 84%. Nearly 450 million events
are collected with a high-energy (E>10 GeV) trigger. By combining all operation
modes with the excellent-quality on-orbit data collected thus far, it is
expected that a five-year observation period will provide a wealth of new and
interesting results.Comment: 11 pages, 7 figures, published online 27 February 201
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