Intra-articular injection of tenoxicam in rats: Assessment of the local effects on the articular cartilage and synovium

This study investigated the possible local adverse effects of intra-articular administration of tenoxicam in the rat knee joint. A total of 50 rats were given 0.25 ml of a standard preparation of tenoxicam by injection into the right knee joint and 0.25 ml of 0.9% saline solution by injection into the left knee joint as a control. Groups of 10 rats were killed 24 h, 48 h, 7 days, 14 days and 21 days after tenoxicam administration. Two rats were sham operated; one was killed on the first day and the other on the second day after this procedure. All the joints were prepared and sectioned for histological examination. Tissue loss and oedema were observed in the specimens obtained 24 h and 48 h after treatment with tenoxicam.. No pathological changes were observed in the 7-day, 14-day and 21-day specimens, or in the control joints. Caution should be exercised when using intra-articular tenoxicam for postoperative analgesia

Radiologic and histomorphometric evaluation of maxillary sinus grafting with alloplastic grafts materials

Background: Sinus lifting procedures are widely used to obtain adequate bony support for implant placement at the atrophic maxillae. The aim of this study was to compare various sinus lifting and grafting techniques and materials

Pain Intensity and Its Objective Determinants Following Implant Surgery and Sinus Lifting: A 1-Year Prospective Study

Objectives: The main goal of this study was to evaluate the relationship between postoperative pain and short-term implant survival. Objective parameters, such as implant-related factors (type, diameter, length) and the surgical approach were also assessed to correlate them with pain. Materials and Methods: This prospective, single-center study consisted of 144 patients scheduled for the surgical placement of one or more implants either with conventional surgery or with sinus-lifting together. All patients were asked to complete a questionnaire form of pain with a visual-analog scale (VAS, 1-10) for 7 days following surgery. The association of pain scores at each time-point was assessed on implant-and surgery-related factors. Results: The overall cumulative survival rate of 546 implants in 144 patients was 98.17 % (10 implants lost) after 1-year follow-up. No statistical difference was found in pain (VAS) scores between patients with loss and survived implants at any observation period. The length and diameter of placed implants and the presence of a sinus-lifting procedure did not influence the pain scores at any period (P > 0.05). In patients with bilateral sinus lifting, the decrease in pain scores was significant after 3 days (P < 0.05), whereas it was significant after 6 hours for the conventionally treated group (P < 0.01). Although no severe pain was reported at any time, this study found a significant difference in pain intensities among different implant brands. Conclusions: This study was able to show that increased postoperative pain is not a sign of early implant failure. In addition to this, the implant dimensions and presence of sinus lifting procedure did not influence the pain experience. However, the bilateral sinus lifting prolongs the recovery time

Effects of Different Local Anaesthetics on Oto-acoustic Emission Tests after Spinal Anaesthesia

Purpose: To evaluate whether there is any effect of different local anaesthetic agents on hearing loss after spinal anaesthesia