1 research outputs found
Synthesis of Alkylated Monofluoroalkenes via Fe-Catalyzed Defluorinative Cross-Coupling of Donor Alkenes with <i>gem</i>-Difluoroalkenes
A reductive
cross-coupling of <i>gem</i>-difluoroalkenes
with diverse unactivated and heteroatom substituted olefins through
a Fe-catalyzed hydrogen atom transfer (HAT) strategy is reported.
Different from the previous HAT-type olefin cross-coupling reactions,
the presence of a fluorine atom in the molecule results in a stereoselective
β-F cleavage, leading to a CÂ(sp<sup>2</sup>)–CÂ(sp<sup>3</sup>) bond formation. A wide variety of alkylated monofluoroalkenes
were obtained in good efficiency with excellent <i>Z</i> selectivity under air- and water-tolerant reaction conditions. A
similar defluorinative coupling reaction of monofluoroalkenes was
also realized