Cultivation and analysis of anthocyanins containing-, blue potatoes

Anthocyanins, as secondary plant substance in different agricultural crops such as potatoes and cereals have positive effects on health due to their antioxidant capacity. Therefore food industry, nutritional medicine and consumers have an increasing interest in these crops. The objectives of the interdisciplinary research project (AGIP) starting in march 2006 are ascertainment and assessment of the impact of different agricultural production processes and production intensities. Furthermore, the impact of different ways of food preparation concerning anthocyanin content and antioxidative capacity in selected cultivated plants will be tested. Main focus will be on potatoes due to the fact that potatoes as a staple food are consumed in large quantities. Therefore potatoes can be an important quantitative source for anthocyanins

Hyperacusis in tinnitus patients relates to enlarged subcortical and cortical responses to sound except at the tinnitus frequency

Hyperacusis, a hypersensitivity to sounds of mild to moderate intensity, has been related to increased neural gain along the auditory pathway. To date, there is still uncertainty on the neural correlates of hyperacusis. Since hyperacusis often co-occurs with hearing loss and tinnitus, the effects of the three conditions on cortical and subcortical structures are often hard to separate. In this fMRI study, two groups of hearing loss and tinnitus participants, with and without hyperacusis, were compared to specifically investigate the effect of the latter in a group that often reports hyperacusis. In 35 participants with hearing loss and tinnitus, with and without hyperacusis as indicated by a cut-off score of 22 on the Hyperacusis Questionnaire (HQ), subcortical and cortical responses to sound stimulation were investigated. In addition, the frequency tuning of cortical voxels was investigated in the primary auditory cortex. In cortical and subcortical auditory structures, sound-evoked activity was higher in the group with hyperacusis. This effect was not restricted to frequencies affected by hearing loss but extended to intact frequencies. The higher subcortical and cortical activity in response to sound thus appears to be a marker of hyperacusis. In contrast, the response to the tinnitus frequency was reduced in the group with hyperacusis. This increase in subcortical and cortical activity in hyperacusis can be related to an increase in neural gain along the auditory pathway, and the reduced response to the tinnitus frequency to differences in attentional resources allocated to the tinnitus sound. (c) 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/

Vormen van subsidiariteit : een historisch-comparatistische studie naar het subsidiariteitsbeginsel bij pand, hypotheek en borgtocht

In several continental Western European legal systems, a person may be liable in person or through his property for payment of a debt which is not his. Both personal surety and a pledge which has been alienated by its owner come to mind. Under such circumstances, the question rises whether a creditor can attach the surety or the pledge before seeking payment from the debtor. According to classical Roman law, the creditor had a right to choose. However, emperor Justinian changed the law in this regard, forcing the creditor to first seek recourse against his debtor, even to the point of insolvency proceedings. This rule later became known as the ‘beneficium ordinis’ or ‘beneficium excussionis / discussionis’. Over the ages, the rule has come under severe attack, which resulted in it either being abandoned or modified, so as not to interfere with creditors’ rights. The author tracks these developments through the medieval European ‘ius commune’ into French law, Roman-Dutch law and modern Dutch law. The latter has extended the rule in 1992 for real security interests, while at the same time abandoning it for sureties. It is asserted that this was a mistake and the rule should be abolished entirely.LEI Universiteit LeidenCoherent privaatrech

Bijzonder recht: het ius promovendi

Van oudsher mogen alleen hoogleraren optreden als promotor. Er ligt een wetsvoorstel klaar om dat te veranderen. Maar wat is het promotierecht precies, en waar komt het vandaan? In deze bijdrage wordt de temperatuur genomen van de graad van doctor in de rechten.Coherent privaatrech

Vermenging is een vat vol tegenstrijdigheden

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Purification and analytical characterization of an anti- CD4 monoclonal antibody for human therapy

A purification process for the monclonal anti-CD4 antibody MAX.16H5 was developed on an analytical scale using (NH&SO, precipitation, anion-exchange chromatography on MonoQ or Q-Sepharose, hydrophobic interaction chromatography on phenyl- Sepharose and gel filtration chromatography on Superdex 200. The purification schedule was scaled up and gram amounts of MAX.16H5 were produced on corresponding BioPilot columns. Studies of the identity, purity and possible contamination by a broad range of methods showed that the product was highly purified and free from contaminants such as mouse DNA, viruses, pyrogens and irritants. Overall, the analytical data confirm that the monoclonal antibody MAX.16H5 prepared by this protocol is suitable for human therapy

Introducing Students to Ethics and Professionalism Challenges in Virtual Communication

As the practice of law, and the conduct of business generally, focuses increasingly on virtual communication, the ethics and professionalism challenges inherent in email, videoconference, text, and telephone communication continue to evolve. These challenges are particularly prevalent in transactional practice, which involves frequent communication with a variety of parties through a variety of communication channels. Exposing law students to these challenges through exercises and simulations contributes to the continued development of their professional identity as lawyers. This article presents a variety of exercises that introduce students to client confidentiality, inadvertent disclosure, and other ethical issues that often arise in the context of virtual communication during a transaction. They also introduce professionalism issues common to transactional practice and explore the relationship between professionalism and ethical duties in transactional practice