109 research outputs found

    Effects of Passive and active Rest on Physiological Responses and Time Motion Characteristics in Different Small Sided Soccer Games

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    The purpose of this study was to investigate the effects of resting regimes on physiological responses and time motion characteristics between bouts during small sided games (SSGs) in young soccer players. Sixteen players (average age 16.87 ± 0.34 years; body height 176.69 ± 3.21 cm; body mass 62.40 ± 2.59 kg; training experience 3.75 ± 0.44 years) performed four bouts 2-a-side, 3-a-side and 4-a-side games with three minutes active (SSGar: Running at 70% of HRmax) and passive (SSGpr) rest between bouts at two-day intervals. The heart rate (HR) along with total distance covered in different speed zones - walking (W, 0-6.9 km·h-1), low-intensity running (LIR, 7.0-12.9 km·h-1), moderate-intensity running (MIR, 13.0-17.9 km·h-1) and high-intensity running (HIR, >18km·h-1), were monitored during all SSGs, whereas the rating of perceived exertion (RPE, CR-20) and venous blood lactate (La-) were determined at the end of the last bout of each SSG. The results demonstrated that all SSGpr elicited significantly higher physiological responses compared to SSGar in terms of the RPE and La- (p < 0.05). In addition, 2-a-side SSGpr induced significantly lower %HRmax responses and total distance covered than 2-a-side SSGar (p < 0.05). Moreover, the distance covered at HIR was significantly higher in 4-a-side SSGar than 4-side SSGpr. The results of this study indicate that both SSGs with passive and active rest can be used for soccer specific aerobic endurance training. Furthermore, all SSGs with active recovery should be performed in order to increase players and teams' performance capacity for subsequent bouts. © 2017 Editorial Committee of Journal of Human Kinetics 2017

    Envisioning the role of inwardly rectifying potassium (Kir) channel in epilepsy

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    Epilepsy is a devastating neurological disorder characterized by recurrent seizures attributed to the disruption of the dynamic excitatory and inhibitory balance in the brain. Epilepsy has emerged as a global health concern affecting about 70 million people worldwide. Despite recent advances in pre-clinical and clinical research, its etiopathogenesis remains obscure, and there are still no treatment strategies modifying disease progression. Although the precise molecular mechanisms underlying epileptogenesis have not been clarified yet, the role of ion channels as regulators of cellular excitability has increasingly gained attention. In this regard, emerging evidence highlights the potential implication of inwardly rectifying potassium (Kir) channels in epileptogenesis. Kir channels consist of seven different subfamilies (Kir1–Kir7), and they are highly expressed in both neuronal and glial cells in the central nervous system. These channels control the cell volume and excitability. In this review, we discuss preclinical and clinical evidence on the role of the several subfamilies of Kir channels in epileptogenesis, aiming to shed more light on the pathogenesis of this disorder and pave the way for future novel therapeutic approaches. © 2021 Wiley Periodicals LLC
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