The possibility to decrease biological activity of chrysotile-asbestos

The paper presents a study of natural chrysotile and 15 samples modified using different temperature and pressure. The morphology, dimensions, chemical composition, crystalline structure, and technologic characteristics of the samples studied were similar. The numbers of negatively charged centers on the surface of fibers were about the same in all the samples. In two modified asbestos samples the number of positively charged centers was less than in the native one. In these samples the energy of interaction of charged centers with macromolecules of rodamin and eozin was also less than in the sample of natural chrysotile. It directly correlated with cytotoxicity and mutagenicity of them. The principal possibility to decrease the biological activity of asbestos has been discussed

Baby MIND: A magnetised spectrometer for the WAGASCI experiment

The WAGASCI experiment being built at the J-PARC neutrino beam line will measure the difference in cross sections from neutrinos interacting with a water and scintillator targets, in order to constrain neutrino cross sections, essential for the T2K neutrino oscillation measurements. A prototype Magnetised Iron Neutrino Detector (MIND), called Baby MIND, is being constructed at CERN to act as a magnetic spectrometer behind the main WAGASCI target to be able to measure the charge and momentum of the outgoing muon from neutrino charged current interactions.Comment: Poster presented at NuPhys2016 (London, 12-14 December 2016). Title + 4 pages, LaTeX, 6 figure

Baby MIND Experiment Construction Status

Baby MIND is a magnetized iron neutrino detector, with novel design features, and is planned to serve as a downstream magnetized muon spectrometer for the WAGASCI experiment on the T2K neutrino beam line in Japan. One of the main goals of this experiment is to reduce systematic uncertainties relevant to CP-violation searches, by measuring the neutrino contamination in the anti-neutrino beam mode of T2K. Baby MIND is currently being constructed at CERN, and is planned to be operational in Japan in October 2017.Comment: Poster presented at NuPhys2016 (London, 12-14 December 2016). 4 pages, LaTeX, 7 figure

Synchronization of the Distributed Readout Frontend Electronics of the Baby MIND Detector

Baby MIND is a new downstream muon range detector for the WGASCI experiment. This article discusses the distributed readout system and its timing requirements. The paper presents the design of the synchronization subsystem and the results of its test

Baby MIND: A magnetized segmented neutrino detector for the WAGASCI experiment

T2K (Tokai-to-Kamioka) is a long-baseline neutrino experiment in Japan designed to study various parameters of neutrino oscillations. A near detector complex (ND280) is located 280~m downstream of the production target and measures neutrino beam parameters before any oscillations occur. ND280's measurements are used to predict the number and spectra of neutrinos in the Super-Kamiokande detector at the distance of 295~km. The difference in the target material between the far (water) and near (scintillator, hydrocarbon) detectors leads to the main non-cancelling systematic uncertainty for the oscillation analysis. In order to reduce this uncertainty a new WAter-Grid-And-SCintillator detector (WAGASCI) has been developed. A magnetized iron neutrino detector (Baby MIND) will be used to measure momentum and charge identification of the outgoing muons from charged current interactions. The Baby MIND modules are composed of magnetized iron plates and long plastic scintillator bars read out at the both ends with wavelength shifting fibers and silicon photomultipliers. The front-end electronics board has been developed to perform the readout and digitization of the signals from the scintillator bars. Detector elements were tested with cosmic rays and in the PS beam at CERN. The obtained results are presented in this paper.Comment: In new version: modified both plots of Fig.1 and added one sentence in the introduction part explaining Baby MIND role in WAGASCI experiment, added information for the affiliation

Polycystin-1 Surface Localization Is Stimulated by Polycystin-2 and Cleavage at the G Protein-coupled Receptor Proteolytic Site

The localization of polycystin (PC)1) to the plasma membrane requires coexpression with PC2 and cleavage at the PC1 G protein-coupled receptor proteolytic site. Neither the PC1 binding capacity of PC2 nor its channel function is required for this effect

The Baby MIND spectrometer for the J-PARC T59(WAGASCI) experiment

The Baby MIND spectrometer is designed to measure the momentum and charge of muons from neutrino interactions in water and hydrocarbon targets at the J-PARC T59 (WAGASCI) experiment. The WAGASCI experiment will measure the ratio of neutrino charged current interaction cross-sections on water and hydrocarbon aiming at reducing systematic errors in neutrino oscillation analyses at T2K. Construction of the Baby MIND detector within the CERN Neutrino Platform framework was completed in June 2017, where it underwent full commissioning and characterization on a charged particle beam line at the Proton Synchrotron experimental hall

The Baby MIND spectrometer for the J-PARC T59(WAGASCI) experiment

The Baby MIND spectrometer is designed to measure the momentum and charge of muons from neutrino interactions in water and hydrocarbon targets at the J-PARC T59 (WAGASCI) experiment. The WAGASCI experiment will measure the ratio of neutrino charged current interaction cross-sections on water and hydrocarbon aiming at reducing systematic errors in neutrino oscillation analyses at T2K. Construction of the Baby MIND detector within the CERN Neutrino Platform framework was completed in June 2017, where it underwent full commissioning and characterization on a charged particle beam line at the Proton Synchrotron experimental hall

Glomerulocystic kidney disease

Glomerulocystic disease is a rare renal cystic disease with a long descriptive history. Findings from recent studies have significantly advanced the pathophysiological understanding of the disease processes leading to this peculiar phenotype. Many genetic syndromes associated with glomerulocystic disease have had their respective proteins localized to primary cilia or centrosomes. Transcriptional control of renal developmental pathways is dysregulated in obstructive diseases that also lead to glomerulocystic disease, emphasizing the importance of transcriptional choreography between renal development and renal cystic disease

Emerging evidence of a link between the polycystins and the mTOR pathways

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized by the formation of renal cysts. This disease can be caused by mutations in two genes, PKD1 and PKD2, which encode polycystin-1 (PC-1) and -2 (PC-2), respectively