Pomiar parametrów torów telewizyjnych metodą linii kontrolnej. Część II. Przegląd Zagadnień Łączności, 1967, nr 10 (73)

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Maternal exposure to air pollution before and during pregnancy related to changes in newborn's cord blood lymphocyte subpopulations. The EDEN study cohort

<p>Abstract</p> <p>Background</p> <p>Toxicants can cross the placenta and expose the developing fetus to chemical contamination leading to possible adverse health effects, by potentially inducing alterations in immune competence. Our aim was to investigate the impacts of maternal exposure to air pollution before and during pregnancy on newborn's immune system.</p> <p>Methods</p> <p>Exposure to background particulate matter less than 10 μm in diameter (PM₁₀) and nitrogen dioxide (NO₂) was assessed in 370 women three months before and during pregnancy using monitoring stations. Personal exposure to four volatile organic compounds (VOCs) was measured in a subsample of 56 non-smoking women with a diffusive air sampler during the second trimester of pregnancy. Cord blood was analyzed at birth by multi-parameter flow cytometry to determine lymphocyte subsets.</p> <p>Results</p> <p>Among other immunophenotypic changes in cord blood, decreases in the CD4+CD25+ T-cell percentage of 0.82% (p = 0.01), 0.71% (p = 0.04), 0.88% (p = 0.02), and 0.59% (p = 0.04) for a 10 μg/m³increase in PM₁₀levels three months before and during the first, second and third trimester of pregnancy, respectively, were observed after adjusting for confounders. A similar decrease in CD4+CD25+ T-cell percentage was observed in association with personal exposure to benzene. A similar trend was observed between NO₂exposure and CD4+CD25+ T-cell percentage; however the association was stronger between NO₂exposure and an increased percentage of CD8+ T-cells.</p> <p>Conclusions</p> <p>These data suggest that maternal exposure to air pollution before and during pregnancy may alter the immune competence in offspring thus increasing the child's risk of developing health conditions later in life, including asthma and allergies.</p

Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review

BACKGROUND: Acute hematogenous osteomyelitis (AHO) occurs primarily in children and is believed to evolve from bacteremia followed by localization of infection to the metaphysis of bones. Currently, there is no consensus on the route and duration of antimicrobial therapy to treat AHO. METHODS: We conducted a systematic review of a short versus long course of treatment for AHO due primarily to Staphylococcus aureus in children aged 3 months to 16 years. We searched Medline, Embase and the Cochrane trials registry for controlled trials. Clinical cure rate at 6 months was the primary outcome variable, and groups receiving less than 7 days of intravenous therapy were compared with groups receiving one week or longer of intravenous antimicrobials. RESULTS: 12 eligible prospective studies, one of which was randomized, were identified. The overall cure rate at 6 months for the short course of intravenous therapy was 95.2% (95% CI = 90.4, 97.7) compared to 98.8% (95% CI = 93.6, 99.8) for the longer course of therapy. There was no significant difference in the duration of oral therapy between the two groups. CONCLUSIONS: Given the potential increased morbidity and cost associated with longer courses of intravenous therapy, this finding should be confirmed through a randomized controlled equivalence trial

Use of application system and their impact on improving processes associated with road infrastructure management

Zastosowanie aplikacji systemowych i ich wpływ na usprawnienie procesów związanych z zarządzaniem infrastrukturą drogową. Zarządzanie siecią dróg stanowi szeroki zakres działań i obowiązków powierzonych administracji publicznej danego szczebla. Jednym z podstawowych zadań należących do zarządcy dróg danej kategorii jest ich ewidencjonowanie i stałe aktualizowanie tej ewidencji. Niniejsza praca stanowi ocenę stanu oraz jakości funkcjonowania ewidencji dróg na szczeblu powiatowym oraz ocenę stopnia wdrożenie systemów geoinformacyjnych do ewidencjonowania dróg. Zastosowanie oprogramowania Geomedia umożliwiło wizualizację wyników przeprowadzonych przez autora badań w postaci map tematycznych obrazujących aktualne tendencje rozwojowe i problemy związane z wdrażaniem elektronicznej ewidencji dróg.Use of application system and their impact on improving processes associated with road infrastructure management. The management in road network is the range of entrusted operations and duties of proper range of administration. One of the basic road manager’s task is recording of the roads and continuous it in the future. This paper present estimate condition and quality of functioning recording at the district level, what is more the process of accustoming road recording geoinformation systems. Using the Geomedia has allowed to show thematic maps as a result of research. It presents current development trend and problems related to accustoming electronic road recording