2,373 research outputs found
A continuous discharge improves the performance of the Cu/CuCl double pulse laser
A continuous glow discharge was applied to a Cu/CuCl double pulse laser. Maximum laser pulse energy was observed to increase as much as 35 percent at low buffer gas pressure and 3.5 percent at optimum buffer gas pressure. Minimum and optimum time delays decreased with increasing glow discharge current. The greater pulse energy may be due to increased rate of current rise of the pumping discharge pulse, and decreased contribution to the population of metastable copper from ion recombination
Electron collision quenching of CO(v) chemiluminescence in CS2/O2 and CS2/O2/N2O flames
Chemiluminescence from vibrationally excited carbon monoxide formed by the reaction CS+O-->CO(v)+S was observed in CS2/O2 and CS2/O2/N2O flames to which an electric discharge was applied. Although the total amount of chemiluminescence increased with increasing discharge current probably due to enhanced reaction rates as a result of radical formation, the vibrational distribution was quenched, becoming thermal in character. The thermalization is attributed to superelastic electron collisions [e+CO(v)-->e+CO(vâ1)]. The technique demonstrates a sensitive method for detecting collisional transfers between excited states by separating the perturbation (electron collisions) from the initial excitation mechanism (chemical reactions)
A model for the dissociation pulse, afterglow, and laser pulse in the Cu/CuCl double pulse laser
A model which completely describes the Cu/CuCl double pulse laser is presented. The dissociation discharge pulse and afterglow are simulated and the results are used as initial conditions for an analysis of the pumping discharge pulse and laser pulse. Experimental behavior including the minimum, optimum, and maximum delays between pulses, and the dependence of laser pulse energy on dissociation energy are satisfactorily reproduced. An optimum tube temperature is calculated, and the dependence of laser pulse energy on tube temperature (i.e., CuCl vapor pressure) is explained for the first time
Dynamic Control of Explore/Exploit Trade-Off In Bayesian Optimization
Bayesian optimization offers the possibility of optimizing black-box
operations not accessible through traditional techniques. The success of
Bayesian optimization methods such as Expected Improvement (EI) are
significantly affected by the degree of trade-off between exploration and
exploitation. Too much exploration can lead to inefficient optimization
protocols, whilst too much exploitation leaves the protocol open to strong
initial biases, and a high chance of getting stuck in a local minimum.
Typically, a constant margin is used to control this trade-off, which results
in yet another hyper-parameter to be optimized. We propose contextual
improvement as a simple, yet effective heuristic to counter this - achieving a
one-shot optimization strategy. Our proposed heuristic can be swiftly
calculated and improves both the speed and robustness of discovery of optimal
solutions. We demonstrate its effectiveness on both synthetic and real world
problems and explore the unaccounted for uncertainty in the pre-determination
of search hyperparameters controlling explore-exploit trade-off.Comment: Accepted for publication in the proceedings of 2018 Computing
Conferenc
A fully-discrete scheme for systems of nonlinear Fokker-Planck-Kolmogorov equations
We consider a system of Fokker-Planck-Kolmogorov (FPK) equations, where the
dependence of the coefficients is nonlinear and nonlocal in time with respect
to the unknowns. We extend the numerical scheme proposed and studied recently
by the authors for a single FPK equation of this type. We analyse the
convergence of the scheme and we study its applicability in two examples. The
first one concerns a population model involving two interacting species and the
second one concerns two populations Mean Field Games
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ranacapa: An R package and Shiny web app to explore environmental DNA data with exploratory statistics and interactive visualizations.
Environmental DNA (eDNA) metabarcoding is becoming a core tool in ecology and conservation biology, and is being used in a growing number of education, biodiversity monitoring, and public outreach programs in which professional research scientists engage community partners in primary research. Results from eDNA analyses can engage and educate natural resource managers, students, community scientists, and naturalists, but without significant training in bioinformatics, it can be difficult for this diverse audience to interact with eDNA results. Here we present the R package ranacapa, at the core of which is a Shiny web app that helps perform exploratory biodiversity analyses and visualizations of eDNA results. The app requires a taxonomy-by-sample matrix and a simple metadata file with descriptive information about each sample. The app enables users to explore the data with interactive figures and presents results from simple community ecology analyses. We demonstrate the value of ranacapa to two groups of community partners engaging with eDNA metabarcoding results
Low-Frequency Sonophoresis: Application to the Transdermal Delivery of Macromolecules and Hydrophilic Drugs
Importance of the field: Transdermal delivery of macromolecules provides an attractive alternative route of drug administration when compared to oral delivery and hypodermic injection because of its ability to bypass the harsh gastrointestinal tract and deliver therapeutics non-invasively. However, the barrier properties of the skin only allow small, hydrophobic permeants to traverse the skin passively, greatly limiting the number of molecules that can be delivered via this route. The use of low-frequency ultrasound for the transdermal delivery of drugs, referred to as low-frequency sonophoresis (LFS), has been shown to increase skin permeability to a wide range of therapeutic compounds, including both hydrophilic molecules and macromolecules. Recent research has demonstrated the feasibility of delivering proteins, hormones, vaccines, liposomes and other nanoparticles through LFS-treated skin. In vivo studies have also established that LFS can act as a physical immunization adjuvant. LFS technology is already clinically available for use with topical anesthetics, with other technologies currently under investigation.
Areas covered in this review: This review provides an overview of mechanisms associated with LFS-mediated transdermal delivery, followed by an in-depth discussion of the current applications of LFS technology for the delivery of hydrophilic drugs and macromolecules, including its use in clinical applications.
What the reader will gain: The reader will gain an insight into the field of LFS-mediated transdermal drug delivery, including how the use of this technology can improve on more traditional drug delivery methods.
Take home message: Ultrasound technology has the potential to impact many more transdermal delivery platforms in the future due to its unique ability to enhance skin permeability in a controlled manner.National Institutes of Health (U.S.) (Grant EB-00351)Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (Grant DAAD-19-02-D-002
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