1,065 research outputs found
Exceeding classical capacity limit in quantum optical channel
The amount of information transmissible through a communications channel is
determined by the noise characteristics of the channel and by the quantities of
available transmission resources. In classical information theory, the amount
of transmissible information can be increased twice at most when the
transmission resource (e.g. the code length, the bandwidth, the signal power)
is doubled for fixed noise characteristics. In quantum information theory,
however, the amount of information transmitted can increase even more than
twice. We present a proof-of-principle demonstration of this super-additivity
of classical capacity of a quantum channel by using the ternary symmetric
states of a single photon, and by event selection from a weak coherent light
source. We also show how the super-additive coding gain, even in a small code
length, can boost the communication performance of conventional coding
technique.Comment: 4 pages, 3 figure
Kinetic modeling and microbial assessment by fluorescent in situ hybridization in anaerobic sequencing batch biofilm reactors treating sulfate-rich wastewater
This paper reports the results of applying anaerobic sequencing batch biofilm reactors (AnSBBR) for treating sulfate-rich wastewater. The reactor was filled with polyurethane foam matrices or with eucalyptus charcoal, used as the support for biomass attachment. Synthetic wastewater was prepared with two ratios between chemical oxygen demand (COD) and sulfate concentration (COD/SO4(2-)) of 0.4 and 3.2. For a COD/SO4(2-) ratio of 3.2, the AnSBBR performance was influenced by the support material used; the average levels of organic matter removal were 67% and 81% in the reactors filled with polyurethane foam and charcoal, respectively, and both support materials were associated with similar levels of sulfate reduction (above 90%). In both reactors, sulfate-reducing bacteria (SRB) represented more than 65% of the bacterial community. The kinetic model indicated equilibrium between complete- and incomplete-oxidizing SRB in the reactor filled with polyurethane foam and predominantly incomplete-oxidizing SRB in the reactor filled with charcoal. Methanogenic activity seems to have been the determining factor to explain the better performance of the reactor filled with charcoal to remove organic matter at a COD/SO4(2-) ratio of 3.2. For a COD/SO4(2-) ratio of 0.4, low values of sulfate reduction (around 32%) and low reaction rates were observed as a result of the small SRB population (about 20% of the bacterial community). Although the support material did not affect overall performance for this condition, different degradation pathways were observed; incomplete oxidation of organic matter by SRB was the main kinetic pathway and methanogenesis was negligible in both reactors.This work was funded by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and the Financiadora de Estudos e Projetos (FINEP), Brazil. The authors acknowledge the grants received from FAPESP and the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazi
Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance
Although chemotherapy is designed to eradicate tumor cells, it also has significant effects on normal tissues. The platinum-induced fatty acid 16:4(n-3) (hexadeca-4,7,10,13-tetraenoic acid) induces systemic resistance to a broad range of DNA-damaging chemotherapeutics. We show that 16:4(n-3) exerts its effect by activating splenic F4/80+/CD11blow macrophages, which results in production of chemoprotective lysophosphatidylcholines (LPCs). Pharmacologic studies, together with analysis of expression patterns, identified GPR120 on F4/80+/CD11blow macrophages as the relevant receptor for 16:4(n-3). Studies that used splenocytes from GPR120-deficient mice have confirmed this conclusion. Activation of the 16:4(n-3)-GPR120 axis led to enhanced cPLA2 activity in these splenic macrophages and secretion of the resistance-inducing lipid mediator, lysophosphatidylcholine(24:1). These studies identify a novel and unexpected function for GPR120 and suggest that antagonists of this receptor might be effective agents to limit development of chemotherapy resistance.—Houthuijzen, J. M., Oosterom, I., Hudson, B. D., Hirasawa, A., Daenen, L. G. M., McLean, C. M., Hansen, S. V. F., van Jaarsveld, M. T. M., Peeper, D. S., Jafari Sadatmand, S., Roodhart, J. M. L., van de Lest, C. H. A., Ulven, T., Ishihara, K., Milligan, G., Voest, E. E. Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance
Ammonia and lactate blood levels on hospital arrival predict neurological outcome in patients with out-of-hospital cardiac arrest
Correlation between IL-6 and S-100B blood levels and outcome of post-cardiac arrest syndrome and influence of therapeutic hypothermia on these mediator blood levels
Large mass dileptons from the passage of jets through quark gluon plasma
We calculate the emission of large mass dileptons originating from the
annihilation of quark jets passing through quark gluon plasma. Considering
central collisions of heavy nuclei at SPS, RHIC and LHC energies, we find that
the yield due to the jet-plasma interaction gets progressively larger as the
collision energy increases. We find it to be negligible at SPS energies, of the
order of the Drell-Yan contribution and much larger than the normal thermal
yield at RHIC energies and up to a factor of ten larger than the Drell-Yan
contribution at LHC energies. An observation of this new dilepton source would
confirm the occurrence of jet-plasma interactions and of conditions suitable
for jet-quenching to take place.Comment: 9 pages, 11 figures; references added, improved calculation,
conclusions unchange
Simulations of Pregalactic Structure Formation with Radiative Feedback
We present results from three-dimensional hydrodynamic simulations of the
high redshift collapse of pregalactic clouds including feedback effects from a
soft H2 photodissociating UV radiation field. The simulations use an Eulerian
adaptive mesh refinement technique to follow the nonequilibrium chemistry of
nine chemical species with cosmological initial conditions drawn from a popular
Lambda-dominated cold dark matter model. The results confirm that the soft UV
background can delay the cooling and collapse of small halos (~10^6 Msun). For
reasonable values of the photo-dissociating flux, the H2 fraction is in
equilibrium throughout most of the objects we simulate. We determine the mass
threshold for collapse for a range of soft-UV fluxes and also derive a simple
analytic expression. Continuing the simulations beyond the point of initial
collapse demonstrates that the fraction of gas which can cool depends mostly on
the virial mass of the halo and the amount of soft-UV flux, with remarkably
little scatter. We parameterize this relation, for use in semi-analytic models.Comment: 18 pages, 7 figures, submitted to Ap
Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors
Agonist exposure can cause internalisation of G-protein coupled receptors (GPCRs), which may be a part of desensitisation but also of cellular signaling. Previous methods to study internalisation have been tedious or only poorly quantitative. Therefore, we have developed and validated a quantitative method using a sphingosine-1-phosphate (S1P) receptor as a model. Because of a lack of suitable binding studies, it has been difficult to study S1P receptor internalisation. Using a N-terminal HisG-tag, S1P1 receptors on the cell membrane can be visualised via immunocytochemistry with a specific anti-HisG antibody. S1P-induced internalisation was concentration dependent and was quantified using a microplate reader, detecting either absorbance, a fluorescent or luminescent signal, depending on the antibodies used. Among those, the fluorescence detection method was the most convenient to use. The relative ease of this method makes it suitable to measure a large number of data points, e.g. to compare the potency and efficacy of receptor ligands
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