68 research outputs found

    Термінологія нормативного регулювання господарської діяльності Збройних Сил України потребує гармонізації

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    Бойченко Е. Г. Термінологія нормативного регулювання господарської діяльності Збройних Сил України потребує гармонізації / Е. Г. Бойченко // Актуальні проблеми держави і права : зб. наук. пр. / редкол.: С. В. Ківалов (голов. ред.), В. М. Дрьомін (заст. голов. ред.), Ю. П. Аленін [та ін.] ; МОНмолодьспорт України, НУ «ОЮА». – Одеса : Юрид. л-ра, 2012. – Вип. 68. - С. 391-399.Стаття присвячена проблематиці неоднозначного використання термінології у правовому регулюванні господарської діяльності Збройних Сил України; звертається увага на необхідність гармонізації термінології у даній сфері діяльності, пропонуються шляхи уніфікації застосування у законодавстві визначених юридичних термінів

    Господарсько-економічна діяльність військових частин Збройних Сил України - загальний погляд на проблематику правового регулювання

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    Бойченко Е. Г. Господарсько-економічна діяльність військових частин Збройних Сил України - загальний погляд на проблематику правового регулювання / Е. Г. Бойченко // Актуальні проблеми держави і права : збірник наук. праць. Вип. 64 / НУ «ОЮА» , редкол. С. В. Ківалов (голов. ред.) та ін., відп. за вип. В. М. Дрьомін. – Одеса : Юрид. л-ра, 2012. – С. 405-413.Стаття присвячена узагальненому аналізу стану правового регулювання господарсько-економічної діяльності Збройних Сил України, необхідності збалансування механізмів реалізації існуючого законодавства з цього питання, його удосконалення

    Окремі проблеми правового регулювання господарської діяльності військових частин Збройних Сил України

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    Бойченко Е. Г. Окремі проблеми правового регулювання господарської діяльності військових частин Збройних Сил України / Е. Г. Бойченко // Актуальні проблеми держави і права : зб. наук. пр. / редкол.: С. В. Ківалов (голов. ред.), В. М. Дрьомін (заст. голов. ред.), Ю. П. Аленін [та ін.] ; МОНмолодьспорт України, НУ «ОЮА». – Одеса : Юрид. л-ра, 2012. – Вип. 66. - С. 443-451.Стаття присвячена розгляду специфічності господарської діяльності Збройних Сил України, аналізу правового регулювання питань створення, реорганізації, ліквідації військових частин - суб'єктів господарювання, легалізації їх діяльності; акцентується увага на існуючих неузгодженостях чинного законодавства з цих питань, необхідності їх усунення, а також на необхідності раціоналізації норм військового права, зокрема, шляхом їх кодифікації

    Statistical properties of Lorenz like flows, recent developments and perspectives

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    We comment on mathematical results about the statistical behavior of Lorenz equations an its attractor, and more generally to the class of singular hyperbolic systems. The mathematical theory of such kind of systems turned out to be surprisingly difficult. It is remarkable that a rigorous proof of the existence of the Lorenz attractor was presented only around the year 2000 with a computer assisted proof together with an extension of the hyperbolic theory developed to encompass attractors robustly containing equilibria. We present some of the main results on the statisitcal behavior of such systems. We show that for attractors of three-dimensional flows, robust chaotic behavior is equivalent to the existence of certain hyperbolic structures, known as singular-hyperbolicity. These structures, in turn, are associated to the existence of physical measures: \emph{in low dimensions, robust chaotic behavior for flows ensures the existence of a physical measure}. We then give more details on recent results on the dynamics of singular-hyperbolic (Lorenz-like) attractors.Comment: 40 pages; 10 figures; Keywords: sensitive dependence on initial conditions, physical measure, singular-hyperbolicity, expansiveness, robust attractor, robust chaotic flow, positive Lyapunov exponent, large deviations, hitting and recurrence times. Minor typos corrected and precise acknowledgments of financial support added. To appear in Int J of Bif and Chaos in App Sciences and Engineerin

    Determination of the basin of attraction of a periodic orbit in two dimensions using meshless collocation

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    A contraction metric for an autonomous ordinary differential equation is a Riemannian metric such that the distance between adjacent solutions contracts over time. A contraction metric can be used to determine the basin of attraction of a periodic orbit without requiring information about its position or stability. Moreover, it is robust to small perturbations of the system. In two-dimensional systems, a contraction metric can be characterised by a scalar-valued function. In [9], the function was constructed as solution of a first-order linear Partial Differential Equation (PDE), and numerically constructed using meshless collocation. However, information about the periodic orbit was required, which needed to be approximated. In this paper, we overcome this requirement by studying a second-order PDE, which does not require any information about the periodic orbit. We show that the second-order PDE has a solution, which defines a contraction metric. We use meshless collocation to approximate the solution and prove error estimates. In particular, we show that the approximation itself is a contraction metric, if the collocation points are dense enough. The method is applied to two examples

    The role of nelarabine in the treatment of T-cell acute lymphoblastic leukemia: literature review and own experience

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    Aim. The analysis of experience of nelarabine use in refractory/relapsed T-cell acute lymphoblastic leukemia (T-ALL) depending on the immunophenotype and the line of therapy. Materials and methods. All the patients with relapsed or refractory T-ALL aged from 0 to 18 years who received treatment with nelarabine as a part of the therapeutic element R6 were included in the study. For all patients a detailed immunological analysis of leukemia cells with discrimination of immunological variants TI, TII, TIII or TIV was performed. Patients administered with nelarabine as a first therapeutic element were referred to the first-line therapy group, other patients were referred to the second-line therapy group. Nelarabine was administered as intravenous infusion at a dose of 650 mg/m2, on days 1-5. Allogeneic hematopoietic stem cells transplantation (allo-HSCT) was considered for all patients. Results. From 2009 to 2017, 54 patients with refractory/relapsed T-ALL were treated with nelarabine. Five-year event-free survival (EFS) and overall survival (OS) was 28% for all patients, cumulative risk of relapse (CIR) was 27%. EFS was significantly higher in nelarabine first-line therapy group in comparison with second-line therapy group (34±8% vs 8±8%, p=0,05). In patients after allo-HSCT EFS, OS and CIR were 51±10%, 50±10% and 39,1±9,5% accordingly. The best results were achieved in patients with TI immunophenotype. No toxicity-related mortality as well as severe neurologic complications or discontinuation of therapy associated with use of nelarabine were reported. Conclusion. The use of nelarabine is an effective strategy for the treatment of relapsed and refractory T-ALL. The best treatment outcomes were obtained in patients with TI immunophenotype and in the first-line therapy group. Optimal dosage regimens can be established during controlled clinical trials

    Removal and Reconstitution of the Carotenoid Antenna of Xanthorhodopsin

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    Salinixanthin, a C40-carotenoid acyl glycoside, serves as a light-harvesting antenna in the retinal-based proton pump xanthorhodopsin of Salinibacter ruber. In the crystallographic structure of this protein, the conjugated chain of salinixanthin is located at the protein–lipid boundary and interacts with residues of helices E and F. Its ring, with a 4-keto group, is rotated relative to the plane of the π-system of the carotenoid polyene chain and immobilized in a binding site near the β-ionone retinal ring. We show here that the carotenoid can be removed by oxidation with ammonium persulfate, with little effect on the other chromophore, retinal. The characteristic CD bands attributed to bound salinixanthin are now absent. The kinetics of the photocycle is only slightly perturbed, showing a 1.5-fold decrease in the overall turnover rate. The carotenoid-free protein can be reconstituted with salinixanthin extracted from the cell membrane of S. ruber. Reconstitution is accompanied by restoration of the characteristic vibronic structure of the absorption spectrum of the antenna carotenoid, its chirality, and the excited-state energy transfer to the retinal. Minor modification of salinixanthin, by reducing the carbonyl C=O double bond in the ring to a C-OH, suppresses its binding to the protein and eliminates the antenna function. This indicates that the presence of the 4-keto group is critical for carotenoid binding and efficient energy transfer

    Review on computational methods for Lyapunov functions

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    Lyapunov functions are an essential tool in the stability analysis of dynamical systems, both in theory and applications. They provide sufficient conditions for the stability of equilibria or more general invariant sets, as well as for their basin of attraction. The necessity, i.e. the existence of Lyapunov functions, has been studied in converse theorems, however, they do not provide a general method to compute them. Because of their importance in stability analysis, numerous computational construction methods have been developed within the Engineering, Informatics, and Mathematics community. They cover different types of systems such as ordinary differential equations, switched systems, non-smooth systems, discrete-time systems etc., and employ di_erent methods such as series expansion, linear programming, linear matrix inequalities, collocation methods, algebraic methods, set-theoretic methods, and many others. This review brings these different methods together. First, the different types of systems, where Lyapunov functions are used, are briefly discussed. In the main part, the computational methods are presented, ordered by the type of method used to construct a Lyapunov function

    Algal Photosynthesis as the Primary Driver for a Sustainable Development in Energy, Feed, and Food Production

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    High oil prices and global warming that accompany the use of fossil fuels are an incentive to find alternative forms of energy supply. Photosynthetic biofuel production represents one of these since for this, one uses renewable resources. Sunlight is used for the conversion of water and CO2 into biomass. Two strategies are used in parallel: plant-based production via sugar fermentation into ethanol and biodiesel production through transesterification. Both, however, exacerbate other problems, including regional nutrient balancing and the world's food supply, and suffer from the modest efficiency of photosynthesis. Maximizing the efficiency of natural and engineered photosynthesis is therefore of utmost importance. Algal photosynthesis is the system of choice for this particularly for energy applications. Complete conversion of CO2 into biomass is not necessary for this. Innovative methods of synthetic biology allow one to combine photosynthetic and fermentative metabolism via the so-called Photanol approach to form biofuel directly from Calvin cycle intermediates through use of the naturally transformable cyanobacterium Synechocystis sp. PCC 6803. Beyond providing transport energy and chemical feedstocks, photosynthesis will continue to be used for food and feed applications. Also for this application, arguments of efficiency will become more and more important as the size of the world population continues to increase. Photosynthetic cells can be used for food applications in various innovative forms, e.g., as a substitute for the fish proteins in the diet supplied to carnivorous fish or perhaps—after acid hydrolysis—as a complex, animal-free serum for growth of mammalian cells in vitro
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