District Committees of Public Security in Yakut Region in Period of Revolution of 1917: Forming and Activities

The activity of district committees of public security, which began to appear after the formation of the Yakut Committee of public security on March 4, 1917, is considered. It is noted that numerous rural and volost committees were subject to the district committees. It is shown that in Yakutia of that period there were 5 districts (Yakutskiy, Vilyuyskiy, Olekminskiy, Verkhoyanskiy and Srednekolymskiy), which appeared after the release of “Regulations on the administration of the Siberian provinces” in 1822. It is reported that the main activities of the public security committees included the provision of food and the maintenance of order in the regions. It is shown that while in the majority of regions in the initial period of the revolution the representatives of the cadet party had the most power, in the Yakutsk region, the Bolsheviks and SRS had the power to control the whole region. A review of the archive materials is made. It is indicated that the greatest amount of material preserved on the activities of the Vilyuyskiy and Olekminskiy districts. The relevance of the study is due to the fact that in the modern period the history of local committees of public security is insufficiently studied, in turn, in the Soviet period, the activities of the committees have always been studied in the context of the problems of the formation of Soviet power. It is concluded that the activities of the committees had a positive impact on the economic condition of the region

EFFECT OF CERULOPLASMIN THE QUANTITATIVE COMPOSITION AND FUNCTIONAL ACTIVITY OF LEUKOCYTES IN ACUTE PHYSICAL LOAD SUBMAXIMAL POWER

In experiments on animals have shown that the use of ceruloplasmin in acute submaximal exercise capacity leads to an increase in neutrophilic leukocytes pool with a change in their functional activity. Increased ability to form aggregates of leukocyte, decrease in chemotaxis. Phagocytic function changes ambiguously — activity of phagocytosis increases, and the intensity decreases

Иммунохимическое исследование бронхиального секрета в оценке степени эндобронхита

We detected albumin (A), lactoferrin (LF), ferritin (F), C-reactive protein (CRP), fibrinogen degradation products (FDP), serum α-, β- and g-globulins, non-specific tissue esterase (NTE), total and placental alkaline phosphatase (TAP and PAP) dynamically in the bronchial secretion (sputum and bronchial aspirates) of 268 patients with bronchopulmonary pathology (pneumonia, chronic non-specific lung diseases, lung abscess, tuberculosis, lung tumours, pleural empyema) using immunochemical methods with rabbit anti-sera and corresponding reagents.A strong correlations between a width of the antigen spectrum and endoscopic, clinical-and-radiological, cytological or bacteriological evidences of endobronchitis seventy were found. The appearance of NTE and PAF thermoresistent forms demonstrates a high risk for malignance development or tumor occurrence.С помощью кроличьих антисывороток и соответствующих реактивов иммунохимическими методами в бронхиальном секрете (мокрота, бронхоаспираты) определяли альбумин (А), лактоферрин (ЛФ), ферритин (Ф), С-реактивный протеин (С-РП), продукты деградации фибриногена (ПДФ), сывороточные α-, β-, g-глобулины, неспецифическую тканевую эстеразу (НТЭ), суммарную и плацентарную щелочную фосфатазу (СЩФ и ПЩФ) у 268 больных с бронхолегочной патологией (пневмония, хронические неспецифические заболевания легких, абсцесс, туберкулез, опухоли легких, эмпиема плевры) в динамике заболевания.Обнаружена высокая корреляция между насыщенностью антигенного спектра бронхиального секрета и эндоскопическим, клинико-рентгенологическим, цитологическим и бактериоскопическим подтверждением степени выраженности эндобронхита. Появление термостабильных изоформ НТЭ и ПЩФ отражает высокий риск или наличие малигнизации

Why do acute respiratory infections in children remain a pressing problem? Current, prevention and treatment options

Literary data on peculiarities of immune system, anti-infectious immunity, including local protection of respiratory tract (lymphaticepithelial pharyngeal system), in children of early and preschool age, causing their higher incidence of acute respiratory infections (ARI) are given in the article. This age period is characterized by «physiological» humoral immune deficiency, reduced activation of the complement system, insufficient synthesis of cytokines, including interferons, T-cell immunosuppression, impaired intercellular cooperation, poor functional activity of natural killers and phagocytes. Despite the large range of means and methods of prophylaxis of infectious and inflammatory diseases of viral and bacterial etiology, it is necessary to search for new approaches taking into account the peculiarities of immune status in young children. The article presents the possibilities of controlling the system of congenital and adaptive immunity with medications, in particular, by using the bacterial lysate Broncho-munal®. The immunoregulatory role of bacterial lysates is presented in detail. The pathogenetic substantiation of the use of bacterial lysate Broncho-munal® for the prevention of acute respiratory infections in children, including children with recurrent respiratory infections is given

What methods are currently available to prevent and treat antibiotic-associated diarrhoea in children?

Unwanted drug reactions of the gastrointestinal tract (GIT), often with the development of antibiotic-associated diarrhoea (AAD), are the most frequent adverse effects of antibacterial therapy in outpatient practice. This review presents the most current data on antibiotic-associated intestinal lesions. It provides up-to-date information on the epidemiology and etiology of microbial factors of AAD and pseudomembranous colitis.The authors cite clinical forms of AAD, which range from idiopathic with a picture of enteritis to pathogen-specific AAD (antibiotic-associated colitis). A comprehensive approach to AAD verification and patient management tactics makes it possible to significantly reduce the number and severity of possible complications. AAD, including C. difficile-associated diarrhoea/colitis, should be suspected in any patient with diarrhoea who has received antibiotics in the previous 2 months. In addition to clinical signs, laboratory tests confirming clostridial infection should be evaluated. The article presents the algorithm of the comprehensive approach to the treatment of antibiotic-associated diarrhea (AAD), which along with the use of metronidazole and vancomycin places a high priority on the probiotics, which not only prevents relapse, but also protects from this pathology.The article presents general characteristics of probiotic preparations, mechanisms of action of probiotics: antagonistic influence on pathogenic and opportunistic bacteria of microbiota, strengthening of mucous barrier of gastrointestinal tract, and also influence on modulation of immune response, as a result of which the chain of mechanisms of immunological protection starts. On the basis of publications of domestic and foreign researchers, the possibilities of using various probiotic strains of bacteria, and in particular, the prospects of using Lactobacillus reuteri, have been considered