Writing Life Stories: A Phenomenological Study of Memory and Meaning for People with Early Stage Alzheimer\u27s Disease

There are an estimated five million Americans living with Alzheimer’s disease; experts believe that by mid-century, that number will more than triple. The disease is the sixth leading case of death in the U.S., and the only one among the top ten with no known cure, treatment or means of prevention. An emerging body of research suggests that providing people with Alzheimer’s opportunities to tell their life stories can help them negotiate their personal identities and may have positive impacts on their sense of self. A hermeneutic phenomenological approach is used to understand the lived experience of people with early stage Alzheimer’s disease in telling their life stories. The study included interviews with eight individuals who participated in a life story-telling program. Three key themes emerged to describe participants’ experience, including sense of self, relationship with family, and sense of purpose and meaning. The study supports the value of narrative approaches in contributing to positive self-image for people with AD. Implications for social work research and practice are discussed

Controlling The pH Of Cultures Of Penicillium Notatum Through Its Carbon And Nitrogen Nutrition

A survey of published material reveals relatively little information concerning the nutritional physiology of Penicillium notatum Westl. on synthetic media. Metabolism studies of P. notatum on various media have appeared to be incidental to the more pressing problem of producing penicillin quickly and in quantity. Fleming (1929) originally used a nutrient broth non-synthetic in nature. The Oxford group (Abraham et al., 1941) then adopted a modification of the so-called Czapek-Dox synthetic medium which supplies nitrogen as sodium nitrate and glucose as carbohydrate. Hobby, Meyer, and Chaffee (1942) suggested that brown sugar be substituted for glucose in this nutrient, with resultant higher yields and decreased time for maximum production of penicillin. Apparently a variety of carbon and nitrogen sources have been employed in liquid nutrients (Foster, 1943; Foster, Woodruff and McDaniel, 1943; McKee and Rake, 1942; Kocholaty, 1942; Waksman and Horning, 1943); but specific data have not been offered. At the present time corn steep liquor appears to be an important component of the medium used

Progress on the Development of Future Airport Surface Wireless Communications Network

Continuing advances in airport surface management and improvements in airport surface safety are required to enable future growth in air traffic throughout the airspace, as airport arrival and departure delays create a major system bottleneck. These airport management and safety advances will be built upon improved communications, navigation, surveillance, and weather sensing, creating an information environment supporting system automation. The efficient movement of the digital data generated from these systems requires an underlying communications network infrastructure to connect data sources with the intended users with the required quality of service. Current airport surface communications consists primarily of buried copper or fiber cable. Safety related communications with mobile airport surface assets occurs over 25 kHz VHF voice and data channels. The available VHF spectrum, already congested in many areas, will be insufficient to support future data traffic requirements. Therefore, a broadband wireless airport surface communications network is considered a requirement for the future airport component of the air transportation system. Progress has been made on defining the technology and frequency spectrum for the airport surface wireless communications network. The development of a test and demonstration facility and the definition of required testing and standards development are now underway. This paper will review the progress and planned future work

Healthy Sleep Leads to Improved Nutrition and Exercise in College Females

Diet, sleep quality, and exercise are important determinants of physical, mental, and emotional health. College students are particularly vulnerable to impaired health, as they experience multiple unique stressors associated with college life that impact their ability to engage in healthy sleep, diet, and exercise habits. Our results found that exercise significantly mediated the association between sleep quality and diet. Improved sleep habits may increase a young woman\u27s ability and desire to exercise, thus impacting her diet and nutrition. Findings suggest that clinicians can use a person\u27s motivation in any one domain, or multiple domains, to impact other health domains

Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer

Transposon mutagenesis is a widely applied and powerful genetic tool for the discovery of genes associated with selected phenotypes. Chlamydia trachomatis is a clinically significant, obligate intracellular bacterium for which many conventional genetic tools and capabilities have been developed only recently. This report describes the successful development and application of a Himar transposon mutagenesis system for generating single-insertion mutant clones of C. trachomatis. This system was used to generate a pool of 105 transposon mutant clones that included insertions in genes encoding flavin adenine dinucleotide (FAD)-dependent monooxygenase (C. trachomatis 148 [ct148]), deubiquitinase (ct868), and competence-associated (ct339) proteins. A subset of Tn mutant clones was evaluated for growth differences under cell culture conditions, revealing that most phenocopied the parental strain; however, some strains displayed subtle and yet significant differences in infectious progeny production and inclusion sizes. Bacterial burden studies in mice also supported the idea that a FAD-dependent monooxygenase (ct148) and a deubiquitinase (ct868) were important for these infections. The ct339 gene encodes a hypothetical protein with limited sequence similarity to the DNA-uptake protein ComEC. A transposon insertion in ct339 rendered the mutant incapable of DNA acquisition during recombination experiments. This observation, along with in situ structural analysis, supports the idea that this protein is playing a role in the fundamental process of lateral gene transfer similar to that of ComEC. In all, the development of the Himar transposon system for Chlamydia provides an effective genetic tool for further discovery of genes that are important for basic biology and pathogenesis aspects.S.D.L., Z.E.D., K.S.H., S.B., R.J.S., and P.S.H. were funded by NIH (AI126785)J.W. and P.S.H. were supported by NIH AI125929. P.S.H. was also supported by P20GM113117Support for genomic sequencing was supplemented by P20GM10363

Toward ending segregation in the 1980s

The conflict concerning desegregation in the 1970s has roots and implications that extend beyond schooling to all aspects of life in metropolitan America. The issue is whether the ghettoization of blacks in areas distinct and separate from protected white enclaves will continue as the vehicle for imposing caste inequality. The challenge for the 1980s is to develop constructive policies and practices in education and training, jobs and housing, and urban development and taxation that will work to end the mutually destructive process of racial segregation across the national landscape. This article explores a number of control, incentive, market, and cooperative approaches to breaching the color line of racial ghettoization.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43868/1/11256_2005_Article_BF01956009.pd

Structural and ligand binding analyses of the periplasmic sensor domain of RsbU in Chlamydia trachomatis support a role in TCA cycle regulation

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154297/1/mmi14401-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154297/2/mmi14401_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154297/3/mmi14401.pd

Bostonia: The Boston University Alumni Magazine. Volume 31

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

The role of the smartphone in the transition from medical student to foundation trainee: a qualitative interview and focus group study

Background The transition from medical student to junior doctor is one of the most challenging in medicine, affecting both doctor and patient health. Opportunities to support this transition have arisen from advances in mobile technology and increased smartphone ownership. Methods This qualitative study consisted of six in-depth interviews and two focus groups with Foundation Year 1 Trainees (intern doctors) and final year medical students within the same NHS Trust. A convenience sample of 14 participants was recruited using chain sampling. Interviews and focus groups were recorded, transcribed verbatim, analysed in accordance with thematic analysis and presented below in keeping with the standards for reporting qualitative research. Results Participants represented both high and low intensity users. They used their smartphones to support their prescribing practices, especially antimicrobials through the MicroGuide™ app. Instant messaging, via WhatsApp, contributed to the existing bleep system, allowing coordination of both work and learning opportunities across place and time. Clinical photographs were recognised as being against regulations but there had still been occasions of use despite this. Concerns about public and colleague perceptions were important to both students and doctors, with participants describing various tactics employed to successfully integrate phone use into their practices. Conclusion This study suggests that both final year medical students and foundation trainees use smartphones in everyday practice. Medical schools and healthcare institutions should seek to integrate such use into core curricula/training to enable safe and effective use and further ease the transition to foundation training. We recommend juniors are reminded of the potential risks to patient confidentiality associated with smartphone use