343 research outputs found

    A Comparison of Multiple Frequency and Pulsed Eddy Current Techniques

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    In principle, the same information should be obtainable from. either pulsed or multiple frequency eddy current techniques, provided they utilize comparable frequency ranges. In practice, there are important differences and advantages for each method. Pulse instrumentation is generally cheaper, simpler, and less sophisticated. On the other hand, there has been greater development of theory and instrumentation using sinusoidal eddy currents, so that the equipment is generally more quantitative at present. The basic problem of determining certain paramenters when others may also be varying can be solved by measuring enough quantities to eliminate the unwanted variables, for example, by measuring the pulse response at various time delays or the sinusoidal response at various frequencies. In practice, the number of useful frequencies is strictly limited. Little additional information is obtainable from frequencies for which the skin depth is much greater or much less than the thickness of the sample. Since the frequencies must be spaced to. permit separation by filters, this puts a practical limit of about four on the number of frequencies useful for a given problem. This is not a serious limitation, since one can measure two quantities for each frequency and the total number of pertinent parameters rarely exceeds six. Pulse equipment can more readily handle a wide range of frequencies, but the instrumentation tends to become more elaborate, especially if high frequencies are needed for a particular application, and the repetition rate becomes low if low frequencies are necessary. The reproducibility of pulses is a problem which can be circumvented by the use of bridge techniques, differential coils and other standard techniques. New computer programs and microprocessor equipment have been developed which now make it possible to set up tests and measure parameters directly and precisely without the lengthy optimization calculations once necessary, though the latter will continue to be useful for the design of optimized coils and experiments

    Design of a Temperature-Compensated Induction Extensometer

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    By proper choice of materials, dimensions and circuit parameters, it is possible to design a linear displacement transducer, or extensometer, to have zero net thermal drift over any given temperature range. The chief limitation is the inability of wires and insulation to withstand very high temperatures. An extensometer has been designed and tested which could theoretically measure displacements up to 150 mm with a maximum error of ±0.15 mm caused by thermal effects over the temperature range from 0° to 1000°C. Experimental limitations prevented testing at temperatures higher than 500°C, but measured and theoretical results were in good agreement over that range. The principles involved in the temperature compensation will be discussed

    Protein structure and evolutionary history determine sequence space topology

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    This is the publisher's version, also available electronically from http://genome.cshlp.org/content/15/3/385.Understanding the observed variability in the number of homologs of a gene is a very important unsolved problem that has broad implications for research into coevolution of structure and function, gene duplication, pseudogene formation, and possibly for emerging diseases. Here, we attempt to define and elucidate some possible causes behind the observed irregularity in sequence space. We present evidence that sequence variability and functional diversity of a gene or fold family is influenced by quantifiable characteristics of the protein structure. These characteristics reflect the structural potential for sequence plasticity, i.e., the ability to accept mutation without losing thermodynamic stability. We identify a structural feature of a protein domain—contact density—that serves as a determinant of entropy in sequence space, i.e., the ability of a protein to accept mutations without destroying the fold (also known as fold designability). We show that (log) of average gene family size exhibits statistical correlation (R2 > 0.9.) with contact density of its three-dimensional structure. We present evidence that the size of individual gene families are influenced not only by the designability of the structure, but also by evolutionary history, e.g., the amount of time the gene family was in existence. We further show that our observed statistical correlation between gene family size and contact density of the structure is valid on many levels of evolutionary divergence, i.e., not only for closely related sequence, but also for less-related fold and superfamily levels of homology

    A Pulsed Eddy Current Method for Examining Thin-Walled Stainless Steel Tubing

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    A bellows is fabricated from a 12-in. section of type 321 or type 216 stainless steel tubing. In order to ensure that the bellows will survive the rigors of the production environment, it is essential that the tubing be free of all “scratch like” defects. A feasibility study was conducted to determine if an eddy current method could be developed to nondestructively examine this tubing

    A Determination of the Wave Forms and Laws of Propagation and Dissipation of Ballistic Shock Waves

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    Experiments to ascertain the wave forms and laws of propagation and dissipation of ballistic shock waves to large distances (80 yards) from the bullet trajectory are described. Calibers 0.30, 0.50, 20 mm, and 40 mm were studied. In every case an N‐shaped wave profile was observed consisting of a sudden rise in pressure, the “head discontinuity,” followed by an approximately linear decline to a pressure about equally far below atmospheric and then a second sudden return, the “tail discontinuity,” to atmospheric pressure. The peak amplitudes of this disturbance are found to diminish about as the inverse 3/4 power of the miss‐distance (perpendicular distance from the trajectory) while the period Tâ€Č (measured between the discontinuous fronts) increases about as the 1/4 power of the miss‐distance for calibers 0.30, 0.50, and 20 mm. For 40‐mm shells the amplitude decays a little faster, about as the inverse 0.9 power of miss‐distance over the range studied. A theory taking account of the dissipation of the N‐wave energy into heat is developed to explain the observed behavior. A method of measuring absolute N‐wave amplitudes by observing the rate of change of period Tâ€Č with propagation is described. The theory leads to an absolute relationship at large distances between distance, amplitude, and period in which no arbitrary constants appear

    A simple physical model for scaling in protein-protein interaction networks

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    It has recently been demonstrated that many biological networks exhibit a scale-free topology where the probability of observing a node with a certain number of edges (k) follows a power law: i.e. p(k) ~ k^-g. This observation has been reproduced by evolutionary models. Here we consider the network of protein-protein interactions and demonstrate that two published independent measurements of these interactions produce graphs that are only weakly correlated with one another despite their strikingly similar topology. We then propose a physical model based on the fundamental principle that (de)solvation is a major physical factor in protein-protein interactions. This model reproduces not only the scale-free nature of such graphs but also a number of higher-order correlations in these networks. A key support of the model is provided by the discovery of a significant correlation between number of interactions made by a protein and the fraction of hydrophobic residues on its surface. The model presented in this paper represents the first physical model for experimentally determined protein-protein interactions that comprehensively reproduces the topological features of interaction networks. These results have profound implications for understanding not only protein-protein interactions but also other types of scale-free networks.Comment: 50 pages, 17 figure

    Scaling relations for eddy current phenomena

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    Formulas are given for various electromagnetic quantities for coils in the presence of conductors, with the scaling parameters factored out so that small-scale model experiments can be related to large-scale apparatus. Particular emphasis is given to such quantities as eddy current heating, forces, power, and induced magnetic fields. For axially symmetric problems, closed-form integrals are available for the vector potential and all the other quantities obtainable from it. For unsymmetrical problems, a three-dimensional relaxation program can be used to obtain the vector potential and then the derivable quantities. Data on experimental measurements are given to verify the validity of the scaling laws for forces, inductances, and impedances. Indirectly these also support the validity of the scaling of the vector potential and all of the other quantities obtained from it. (auth
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