Stable oxygen isotope record of the Eocene-Oligocene transition in the southern North Sea Basin: positioning the Oi-1 event

Preliminary stable oxygen isotope data are presented from the southern North Sea Basin successions, ranging from the Lutetian to Rupelian. Analyses were performed on fish otoliths, nuculid bivalves and benthic foraminifera and are presented as bulk delta(18)O values relative to a well established regional sequence stratigraphic framework. The most significant positive shift in delta(18)O values clearly falls at the top of the regionally recognised Bassevelde 3 sequence, which base corresponds to the Eocene-Oligocene GSSP boundary. The here documented delta(18)O shift is closely associated with the base of the traditional Rupelian unit-stratotype and is tentatively correlated to the globally recognised Oi-1 event

Re-assessment of the new geological map of Belgium: earliest Oligocene dinoflagellate cyst-based ages in the Leuven area (sheet 24 Aarschot)

The dinoflagellate cyst (dinocyst) assemblages of two samples from a temporary outcrop in the vicinity of Haacht (Leuven) have been analysed. The co-occurrence of Areosphaeridium diktyoplokum, Cerebrocysta bartonensis, Glaphyrocysta semitecta, Rombodinium perforatum and Thalassiphora reticulata allows correlation with the North Sea Oligocene-1 zone. As a consequence, the considered unit has a latest Eocene to earliest Oligocene age, equivalent to the age of the marine Tongrian. Comparison of the studied area with the recent 1:50 000 geological map (sheet 24 Aarschot) shows that the current lithostratigraphic interpretation of the analysed section, i.e. the Middle Eocene Maldegem Formation, can no longer be uphold

Vitamin C May Improve Left Ventricular Ejection Fraction : A Meta-Analysis

Background: Vitamin C deprivation can lead to fatigue, dyspnea, oedema and chest pain, which are also symptoms of heart failure (HF). In animal studies vitamin C has improved contractility and mechanical efficiency of the heart. Compared with healthy people, patients with HF have lower vitamin C levels, which are not explained by differences in dietary intake levels, and more severe HF seems to be associated with lower plasma vitamin C levels. This meta-analysis looks at the effect of vitamin C on left ventricular ejection fraction (LVEF).Methods: We searched for trials reporting the effects of vitamin C on LVEF. We assessed the quality of the trials, and pooled selected trials using the inverse variance, fixed effect options. We used meta-regression to examine the association between the effect of vitamin C on LVEF level and the baseline LVEF level.Results: We identified 15 trials, three of which were excluded from our meta-analysis. In six cardiac trials with 246 patients, vitamin C increased LVEF on average by 12.0% (95% CI 8.1-15.9%; P < 0.001). In six non-cardiac trials including 177 participants, vitamin C increased LVEF on average by 5.3% (95% CI 2.0-8.5%; P = 0.001). In meta-regression analysis we found that the effect of vitamin C was larger in trials with the lowest baseline LVEF levels with P = 0.001 for the test of slope. The meta-regression line crossed the null effect level at a baseline LVEF level close to 70%, with progressively greater benefit from vitamin C with lower LVEF levels. Some of the included trials had methodological limitations. In a sensitivity analysis including only the four most methodologically sound cardiac trials, the effect of vitamin C was not substantially changed.Conclusions: In this meta-analysis, vitamin C increased LVEF in both cardiac and non-cardiac patients, with a strong negative association between the size of the vitamin C effect and the baseline LVEF. Further research on vitamin C and HF should be carried out, particularly in patients who have low LVEF together with low vitamin C intake or low plasma levels. Different dosages and different routes of administration should be compared.Peer reviewe

Development of a high-sensitivity torsion balance to investigate the thermal Casimir force

We report development of a high-sensitivity torsion balance to measure the thermal Casimir force. Special emphasis is placed on experimental investigations of a possible surface electric force originating from surface patch potentials that have been recently noticed by several experimental groups. By gaining a proper understanding of the actual contribution of the surface electric force in real materials, we aim to undertake precision force measurements to resolve the Casimir force at finite temperature in real metals, as well as in other semiconducting materials, such as graphene.Comment: Proceedings of the 10th International Conference "Quantum Field Theory Under the Influence of External Conditions"; 11 pages and 4 figure

Disused Paleogene regional stages from Belgium: Montian, Heersian, Landenian, Paniselian, Bruxellian, Laekenian, Ledian, Wemmelian and Tongrian

An overview of nine disused Paleogene regional stages from Belgium is presented. Some of these regional chronostratigraphic units were already brought into use in the nineteenth century, but are nowadays considered ill defined and of no use in the light of the modern stratigraphic concepts. An overview of their definition and history is given, together with the argumentation for the abandonment of each unit and its present status. The disused chronostratigraphic units belong to the Paleocene, Eocene and Oligocene series

Synthesis and biological evaluation of immunoconjugates of adriamycin and a human IgM linked by poly[N5-(2-hydroxyethyl)-l-glutamine

The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody (IgM 16.88) directed against an intracellular tumour-associated antigen, the drug carrier poly[N5-(2-hydroxyethyl)--glutamine] (PHEG) and the cytostatic drug adriamycin (ADR) are described. The immunoconjugates were constructed to allow selective release of ADR in the putatively acidic environment of the tumour through a novel acid-labile maleamic acid linker. The conjugate of PHEG and the acid-labile ADR derivative effectively released ADR in cytotoxic amounts at a pH of 6.0 as judged from incubation in buffer and from inhibition of the growth of HT-29 colon tumour cells in vitro. Immunoconjugates were prepared by coupling of PHEG-ADR having a hydrolytically stable amide bond with 131I-labelled antibody through thioether bond formation involving a single thiol group at the C-terminus of the polymer chain and maleimido groups introduced onto th

Development of a quantitative real-time detection assay for hepatitis B virus DNA and comparison with two commercial assays

A highly reproducible and sensitive real-time detection assay based on TaqMan technology was developed for the detection of hepatitis B viru

Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy

A new hepatitis B virus variant selected during lamivudine treatment was detected, in which the methionine (rtM204) in the so-called YMDD motif in the C