1,318 research outputs found
On number fields with nontrivial subfields
What is the probability for a number field of composite degree to have a
nontrivial subfield? As the reader might expect the answer heavily depends on
the interpretation of probability. We show that if the fields are enumerated by
the smallest height of their generators the probability is zero, at least if
. This is in contrast to what one expects when the fields are enumerated
by the discriminant. The main result of this article is an estimate for the
number of algebraic numbers of degree and bounded height which generate
a field that contains an unspecified subfield of degree . If
we get the correct asymptotics as the height tends to
infinity
Two-dimensional Lattice Gauge Theories with Superconducting Quantum Circuits
A quantum simulator of U(1) lattice gauge theories can be implemented with
superconducting circuits. This allows the investigation of confined and
deconfined phases in quantum link models, and of valence bond solid and spin
liquid phases in quantum dimer models. Fractionalized confining strings and the
real-time dynamics of quantum phase transitions are accessible as well. Here we
show how state-of-the-art superconducting technology allows us to simulate
these phenomena in relatively small circuit lattices. By exploiting the strong
non-linear couplings between quantized excitations emerging when
superconducting qubits are coupled, we show how to engineer gauge invariant
Hamiltonians, including ring-exchange and four-body Ising interactions. We
demonstrate that, despite decoherence and disorder effects, minimal circuit
instances allow us to investigate properties such as the dynamics of electric
flux strings, signaling confinement in gauge invariant field theories. The
experimental realization of these models in larger superconducting circuits
could address open questions beyond current computational capability.Comment: Published versio
Irreversible reorganization in a supercooled liquid originates from localised soft modes
The transition of a fluid to a rigid glass upon cooling is a common route of
transformation from liquid to solid that embodies the most poorly understood
features of both phases1,2,3. From the liquid perspective, the puzzle is to
understand stress relaxation in the disordered state. From the perspective of
solids, the challenge is to extend our description of structure and its
mechanical consequences to materials without long range order. Using computer
simulations, we show that the localized low frequency normal modes of a
configuration in a supercooled liquid are causally correlated to the
irreversible structural reorganization of the particles within that
configuration. We also demonstrate that the spatial distribution of these soft
local modes can persist in spite of significant particle reorganization. The
consequence of these two results is that it is now feasible to construct a
theory of relaxation length scales in glass-forming liquids without recourse to
dynamics and to explicitly relate molecular properties to their collective
relaxation.Comment: Published online: 20 July 2008 | doi:10.1038/nphys1025 Available from
http://www.nature.com/nphys/journal/v4/n9/abs/nphys1025.htm
Dosing regimen of gentamicin in neonates: evaluation of current guidelines based on a large population pharmacokinetic analysis
Objectives: Gentamicin is among the most commonly prescribed antibiotics in newborns, but large interindividual variability in exposure levels exists. Based on a population pharmacokinetic analysis of a cohort of unselected neonates, we aimed to validate current dosing recommendations from a recent reference guideline (Neofax®).
Methods: From 3039 concentrations collected in 994 preterm (median gestational age 32.3 weeks, range 24.2-36.5) and 455 term newborns, treated at the University Hospital of Lausanne between 2006 and 2011, a population pharmacokinetic analysis was performed with NONMEM®. Model-based simulations were used to assess the ability of dosing regimens to bring concentrations into targets: trough ≤ 1mg/L and peak ~ 8mg/L.
Results: A two-compartment model best characterized gentamicin pharmacokinetics. Model parameters are presented in the table. Body weight, gestational age and postnatal age positively influence clearance, which decreases under dopamine administration. Body weight and gestational age influence the distribution volume. Model based simulations confirm that preterm infants need doses superior to 4 mg/kg, and extended dosage intervals, up to 48 hours for very preterm newborns, whereas most term newborns would achieve adequate exposure under 4 mg/kg q. 24 h. More than 90% of neonates would achieve trough concentrations below 2 mg/L and peaks above 6 mg/L following most recent guidelines.
Conclusions: Simulated gentamicin exposure demonstrates good accordance with recent dosing recommendations for target concentration achievement
Automatic estimation of harmonic tension by distributed representation of chords
The buildup and release of a sense of tension is one of the most essential
aspects of the process of listening to music. A veridical computational model
of perceived musical tension would be an important ingredient for many music
informatics applications. The present paper presents a new approach to
modelling harmonic tension based on a distributed representation of chords. The
starting hypothesis is that harmonic tension as perceived by human listeners is
related, among other things, to the expectedness of harmonic units (chords) in
their local harmonic context. We train a word2vec-type neural network to learn
a vector space that captures contextual similarity and expectedness, and define
a quantitative measure of harmonic tension on top of this. To assess the
veridicality of the model, we compare its outputs on a number of well-defined
chord classes and cadential contexts to results from pertinent empirical
studies in music psychology. Statistical analysis shows that the model's
predictions conform very well with empirical evidence obtained from human
listeners.Comment: 12 pages, 4 figures. To appear in Proceedings of the 13th
International Symposium on Computer Music Multidisciplinary Research (CMMR),
Porto, Portuga
Novel virus related to Kaposi’s sarcoma-associated herpesvirus from a monkey (Colobus guereza) suffering from primary effusion lymphoma
No abstract available
PathOrganic – Risks and Recommendations Regarding Human Pathogens in Organic Vegetable Production Chains
PathOrganic assesses risks associated with the consumption of fresh and minimally
processed vegetables due to the prevalence of bacterial human pathogens in plant
produce. The project evaluates whether organic production poses a risk on food safety,
taking into consideration sources of pathogen transmission (e.g. animal manure).
The project also explores whether organic versus conventional production practices
may reduce the risk of pathogen manifestation. In Europe, vegetable-linked outbreaks
are not well investigated. A conceptual model together with novel sampling strategies
and specifically adjusted methods provides the basis for large-scale surveys of organically
grown plant produce in five European countries. Critical control points are
determined and evaluated and factors contributing to a food safety problem are analyzed
in greenhouse and field experiments. The project aims at developing a quantitative
risk assessment model and at formulating recommendations for improving food
safety in organic vegetable production
Evaluation of range of motion restriction within the hip joint
In Total Hip Arthroplasty, determining the impingement free range of motion requirement is a complex task. This is because in the native hip, motion is restricted by both impingement as well as soft tissue restraint. The aim of this study is to determine a range of motion benchmark which can identify motions which are at risk from impingement and those which are constrained due to soft tissue. Two experimental methodologies were used to determine motions which were limited by impingement and those motions which were limited by both impingement and soft tissue restraint. By comparing these two experimental results, motions which were limited by impingement were able to be separated from those motions which were limited by soft tissue restraint. The results show motions in extension as well as flexion combined with adduction are limited by soft tissue restraint. Motions in flexion, flexion combined with abduction and adduction are at risk from osseous impingement. Consequently, these motions represent where the maximum likely damage will occur in femoroacetabular impingement or at most risk of prosthetic impingement in Total Hip Arthroplasty
A scalable high-performance magnetic shield for very long baseline atom interferometry
We report on the design, construction, and characterization of a 10 m-long high-performance magnetic shield for very long baseline atom interferometry. We achieve residual fields below 4 nT and longitudinal inhomogeneities below 2.5 nT/m over 8 m along the longitudinal direction. Our modular design can be extended to longer baselines without compromising the shielding performance. Such a setup constrains biases associated with magnetic field gradients to the sub-pm/s2 level in atomic matterwave accelerometry with rubidium atoms and paves the way toward tests of the universality of free fall with atomic test masses beyond the 10-13 level. © 2020 Author(s)
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