Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus.

High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE). Dysregulation of the interferon (IFN) pathway is observed in individuals with active SLE, although the association of specific autoantibodies with chemokine score, a combined measurement of three IFN-regulated chemokines, is not known. To identify autoantibodies associated with chemokine score, we developed giant magnetoresistive (GMR) biosensor microarrays, which allow the parallel measurement of multiple serum antibodies to autoantigens and peptides. We used the microarrays to analyze serum samples from SLE patients and found individuals with high chemokine scores had significantly greater reactivity to 13 autoantigens than individuals with low chemokine scores. Our findings demonstrate that multiple autoantibodies, including antibodies to U1-70K and modified histone H2B tails, are associated with IFN dysregulation in SLE. Further, they show the microarrays are capable of identifying autoantibodies associated with relevant clinical manifestations of SLE, with potential for use as biomarkers in clinical practice

Commercial Building Partnerships Replication and Diffusion

This study presents findings from survey and interview data investigating replication efforts of Commercial Building Partnership (CBP) partners that worked directly with the Pacific Northwest National Laboratory (PNNL). PNNL partnered directly with 12 organizations on new and retrofit construction projects, which represented approximately 28 percent of the entire U.S. Department of Energy (DOE) CBP program. Through a feedback survey mechanism, along with personal interviews, PNNL gathered quantitative and qualitative data relating to replication efforts by each organization. These data were analyzed to provide insight into two primary research areas: 1) CBP partners’ replication efforts of technologies and approaches used in the CBP project to the rest of the organization’s building portfolio (including replication verification), and, 2) the market potential for technology diffusion into the total U.S. commercial building stock, as a direct result of the CBP program. The first area of this research focused specifically on replication efforts underway or planned by each CBP program participant. Factors that impact replication include motivation, organizational structure and objectives firms have for implementation of energy efficient technologies. Comparing these factors between different CBP partners revealed patterns in motivation for constructing energy efficient buildings, along with better insight into market trends for green building practices. The second area of this research develops a diffusion of innovations model to analyze potential broad market impacts of the CBP program on the commercial building industry in the United States

EnergyWeb Screening Criteria Report

This report describes a framework for evaluating candidate participants in the Bonneville Power Administration's (BPA) EnergyWeb program. The framework includes definition of system goals, relevant material that characterizes a distributed energy resource (DER) participant, rules for evaluating candidate participants, and a process that utilizes this information to produce a list of the most attractive candidates

Environmental changes and violent conflict

This letter reviews the scientific literature on whether and how environmental changes affect the risk of violent conflict. The available evidence from qualitative case studies indicates that environmental stress can contribute to violent conflict in some specific cases. Results from quantitative large-N studies, however, strongly suggest that we should be careful in drawing general conclusions. Those large-N studies that we regard as the most sophisticated ones obtain results that are not robust to alternative model specifications and, thus, have been debated. This suggests that environmental changes may, under specific circumstances, increase the risk of violent conflict, but not necessarily in a systematic way and unconditionally. Hence there is, to date, no scientific consensus on the impact of environmental changes on violent conflict. This letter also highlights the most important challenges for further research on the subject. One of the key issues is that the effects of environmental changes on violent conflict are likely to be contingent on a set of economic and political conditions that determine adaptation capacity. In the authors' view, the most important indirect effects are likely to lead from environmental changes via economic performance and migration to violent conflict. © 2012 IOP Publishing Ltd

Inclusive Particle Spectra at RHIC

A simulation is performed of the recently reported data from PHOBOS at energies of 56 and 130 A GeV using the relativistic heavy ion cascade LUCIFER which had previously given a good description of the NA49 inclusive spectra at E=17.2 A GeV. The results compare well with these early measurements at RHIC.Comment: 4 pages, 2 figure

Probing the boundaries of the Hadronic Phase through a Strangeness including Statistical Bootstrap Model (S-SBM)

A recently constructed strangeness-including Statistical Bootstrap Model (S-SBM), which defines the limits of the hadronic phase and provides for a phase beyond, is further extended so as to include a factor that describes strangeness suppression. The model is then used to analyse the multiplicity data from collision experiments in which the colliding entities form isospin symmetric systems, the primary focus being on S+S interactions (NA35 collaboration). An optimal set of thermodynamical variables is extracted through a fit to both the inclusive full phase space and midrapidity data. The assumption that the measured particles originate from a thermally and partial-chemically equilibrated source described by the S-SBM is satisfactorily established. The proximity of the thermodynamical variables extracted from the S+S data to the limits of the hadronic phase is systematically investigated. Finally, experimental data from proton-antiproton collisions (UA5 collaboration) are similarly analysed.Comment: 39 pages, 17 figures, all the figures joined in one file. Submitted in Phys. Rev.

Building America Best Practices Series, Volume 6: High-Performance Home Technologies: Solar Thermal & Photovoltaic Systems

This guide is was written by PNNL for the US Department of Energy's Building America program to provide information for residential production builders interested in building near zero energy homes. The guide provides indepth descriptions of various roof-top photovoltaic power generating systems for homes. The guide also provides extensive information on various designs of solar thermal water heating systems for homes. The guide also provides construction company owners and managers with an understanding of how solar technologies can be added to their homes in a way that is cost effective, practical, and marketable. Twelve case studies provide examples of production builders across the United States who are building energy-efficient homes with photovoltaic or solar water heating systems

Elastic Scattering and Total Cross-Section in p+p reactions measured by the LHC Experiment TOTEM at sqrt(s) = 7 TeV

Proton-proton elastic scattering has been measured by the TOTEM experiment at the CERN Large Hadron Collider at $\sqrt{s} = 7$ TeV in special runs with the Roman Pot detectors placed as close to the outgoing beam as seven times the transverse beam size. The differential cross-section measurements are reported in the |t|-range of 0.36 to 2.5 GeV^2. Extending the range of data to low t values from 0.02 to 0.33 GeV^2,and utilizing the luminosity measurements of CMS, the total proton-proton cross section at sqrt(s) = 7 TeV is measured to be (98.3 +- 0.2(stat) +- 2.8(syst)) mb.Comment: Proceedings of the XLI International Symposium on Multiparticle Dynamics. Accepted for publication in Prog. Theor. Phy

First Results from the TOTEM Experiment

The first physics results from the TOTEM experiment are here reported, concerning the measurements of the total, differential elastic, elastic and inelastic pp cross-section at the LHC energy of $\sqrt{s}$ = 7 TeV, obtained using the luminosity measurement from CMS. A preliminary measurement of the forward charged particle $\eta$ distribution is also shown.Comment: Conference Proceeding. MPI@LHC 2010: 2nd International Workshop on Multiple Partonic Interactions at the LHC. Glasgow (UK), 29th of November to the 3rd of December 201

LHC Optics Measurement with Proton Tracks Detected by the Roman Pots of the TOTEM Experiment

Precise knowledge of the beam optics at the LHC is crucial to fulfil the physics goals of the TOTEM experiment, where the kinematics of the scattered protons is reconstructed with the near-beam telescopes -- so-called Roman Pots (RP). Before being detected, the protons' trajectories are influenced by the magnetic fields of the accelerator lattice. Thus precise understanding of the proton transport is of key importance for the experiment. A novel method of optics evaluation is proposed which exploits kinematical distributions of elastically scattered protons observed in the RPs. Theoretical predictions, as well as Monte Carlo studies, show that the residual uncertainty of this optics estimation method is smaller than 0.25 percent.Comment: 20 pages, 11 figures, 5 figures, to be submitted to New J. Phy