674 research outputs found
When Spheres Collide: A Refocused Research Framework for Personal Use of Technology at Work
Get PDFContinued advancements in technology and more flexible work arrangements have caused employees’ personal and work spheres to collide, increasing the prevalence of the personal use of technology at work. This collision of often competing priorities presents dilemmas for employees in determining how best to manage tasks throughout the day. Prior conceptualizations of “cyberloafing”, “cyberslacking”, “personal web use,” etc. from prior research classify the behavior as unnecessarily negative and often include non-essential constraints. In this paper, we offer an updated definition and refocused research framework that uses novel insights drawn from the multitasking literature to guide researchers in addressing a central question: how can employees most effectively manage their personal use of technology at work? We address various topics and offer research questions to properly align research and practice while re-initiating further investigations into this interesting phenomenon
Consumption of Sugar-Sweetened Beverages Associated With Increased Odds of Depression
Get PDFObjective: To evaluate the association between depression and sugary drink intake using participant data from the Behavioral Risk Factor Surveillance Survey (BRFSS).
Design: Cross-sectional data from the 2012 and 2013 BRFSS were examined (N=44,603). Depression was based on self-report of symptoms within the past 30 days. Covariates included age, sex, race, employment status, body mass index (BMI), education level, and exercise in the past 30 days.
Setting: Data from a national telephone survey (BRFSS) were used to assess risk factors associated with health of the participants.
Subjects: Participants in the 2012 and 2013 BRFSS were included in this analysis (N=44,603). Results: Adjusting for confounders, the odds of depression increased by 5% for every sugary drink consumed (odds ratio (OR)=1.06, 95% confidence interval (CI)=1.02-1.10). Depression was also associated with race, with non-Hispanic blacks being 60% more likely to be depressed than non-Hispanic whites. Unemployment and having a high school or less education were independently associated with depression. The association of depression and consumption of sugar sweetened beverages was stronger among women than men.
Conclusion: This study indicates that consuming sugary drinks are associated with an increased odds of depression. These findings support advocacy efforts for an overall healthy lifestyle. In addition, future research should evaluate this association using a cohort design in order to establish the temporality of this association
Disaggregation and invasion of ovarian carcinoma ascites spheroids
Get PDFBACKGROUND: Malignant ascites often develops in advanced stages of ovarian carcinoma, consisting of single and aggregated tumor cells, or spheroids. Spheroids have commonly been used as tumor models to study drug efficacy, and have shown resistance to some chemotherapies and radiation. However, little is known about the adhesive or invasive capabilities of spheroids, and whether this particular cellular component of the ascites can contribute to dissemination of ovarian cancer. Here, we examined the invasive ability of ascites spheroids recovered from seven ovarian carcinoma patients and one primary peritoneal carcinoma (PPC) patient. METHODS: Ascites spheroids were isolated from patients, purified, and immunohistochemical analyses were performed by a pathologist to confirm diagnosis. In vitro assays were designed to quantify spheroid disaggregation on a variety of extracellular matrices and dissemination on and invasion into normal human mesothelial cell monolayers. Cell proliferation and viability were determined in each assay, and statistical significance demonstrated by the student's t-test. RESULTS: Spheroids from all of the patients' ascites samples disaggregated on extracellular matrix components, with the PPC spheroids capable of complete disaggregation on type I collagen. Additionally, all of the ascites spheroid samples adhered to and disaggregated on live human mesothelial cell monolayers, typically without invading them. However, the PPC ascites spheroids and one ovarian carcinoma ascites spheroid sample occasionally formed invasive foci in the mesothelial cell monolayers, suggestive of a more invasive phenotype. CONCLUSION: We present here in vitro assays using ascites spheroids that imitate the spread of ovarian cancer in vivo. Our results suggest that systematic studies of the ascites cellular content are necessary to understand the biology of ovarian carcinoma
- …
