A novel behavioral fish model of nociception for testing analgesics

Pain is a major symptom in many medical conditions, and often interferes significantly with a person's quality of life. Although a priority topic in medical research for many years, there are still few analgesic drugs approved for clinical use. One reason is the lack of appropriate animal models that faithfully represent relevant hallmarks associated with human pain. Here we propose zebrafish (Danio rerio) as a novel short-term behavioral model of nociception, and analyse its sensitivity and robustness. Firstly, we injected two different doses of acetic acid as the noxious stimulus. We studied individual locomotor responses of fish to a threshold level of nociception using two recording systems: a video tracking system and an electric biosensor (the MOBS system). We showed that an injection dose of 10% acetic acid resulted in a change in behavior that could be used to study nociception. Secondly, we validated our behavioral model by investigating the effect of the analgesic morphine. In time-course studies, first we looked at the dose-response relationship of morphine and then tested whether the effect of morphine could be modulated by naloxone, an opioid antagonist. Our results suggest that a change in behavioral responses of zebrafish to acetic acid is a reasonable model to test analgesics. The response scales with stimulus intensity, is attenuated by morphine, and the analgesic effect of morphine is blocked with naloxone. The change in behavior of zebrafish associated with the noxious stimulus can be monitored with an electric biosensor that measures changes in water impedance. © 2011 by the authors; licensee MDPI, Basel, Switzerland

Rejuvenated accretors have less bound envelopes: Impact of Roche lobe overflow on subsequent common envelope events

Common envelope (CE) evolution is an outstanding open problem in stellar evolution, critical to the formation of compact binaries including gravitational-wave (GW) sources. In the "classical" isolated binary evolution scenario for double compact objects, the CE is usually the second mass transfer phase. Thus, the donor star of the CE is the product of a previous binary interaction, often stable Roche-lobe overflow (RLOF). Because of the accretion of mass during the first RLOF, the main-sequence core of the accretor star grows and is "rejuvenated". This modifies the core-envelope boundary region and decreases significantly the envelope binding energy for the remaining evolution. Comparing accretor stars from self-consistent binary models to stars evolved as single, we demonstrate that the rejuvenation can lower the energy required to eject a CE by $\sim 4 - 58\%$ for both black hole and neutron star progenitors, depending on the evolutionary stage and final orbital separation. Therefore, GW progenitors experiencing a first stable mass transfer may more easily survive subsequent possible CE events and result in possibly wider final separations compared to current predictions. Despite their high mass, our accretors also experience extended "blue loops", which may have observational consequences for low-metallicity stellar populations and asteroseismology.Comment: updated to fix broken link

No peaks without valleys: The stable mass transfer channel for gravitational-wave sources in light of the neutron star-black hole mass gap

Gravitational-wave (GW) detections are starting to reveal features in the mass distribution of double compact objects. The lower end of the black hole (BH) mass distribution is especially interesting as few formation channels contribute here and because it is more robust against variations in the cosmic star formation than the high mass end. In this work we explore the stable mass transfer channel for the formation of GW sources with a focus on the low-mass end of the mass distribution. We conduct an extensive exploration of the uncertain physical processes that impact this channel. We note that, for fiducial assumptions, this channel reproduces the peak at $\sim9 \mathrm{M_{\odot}}$ in the GW-observed binary BH mass distribution remarkably well, and predicts a cutoff mass that coincides with the upper edge of the purported neutron star BH mass gap. The peak and cutoff mass are a consequence of unique properties of this channel, namely (1) the requirement of stability during the mass transfer phases, and (2) the complex way in which the final compact object masses scale with the initial mass. We provide an analytical expression for the cutoff in the primary component mass and show that this adequately matches our numerical results. Our results imply that selection effects resulting from the formation channel alone can provide an explanation for the purported neutron star--BH mass gap in GW detections. This provides an alternative to the commonly adopted view that the gap emerges during BH formation.Comment: Accepted for publication in ApJ associated code is available at https://github.com/LiekeVanSon/LowMBH_and_StableChanne

Understanding Action and Adventure Sports Participation-An Ecological Dynamics Perspective.

Previous research has considered action and adventure sports using a variety of associated terms and definitions which has led to confusing discourse and contradictory research findings. Traditional narratives have typically considered participation exclusively as the pastime of young people with abnormal characteristics or personalities having unhealthy and pathological tendencies to take risks because of the need for thrill, excitement or an adrenaline 'rush'. Conversely, recent research has linked even the most extreme forms of action and adventure sports to positive physical and psychological health and well-being outcomes. Here, we argue that traditional frameworks have led to definitions, which, as currently used by researchers, ignore key elements constituting the essential merit of these sports. In this paper, we suggest that this lack of conceptual clarity in understanding cognitions, perception and action in action and adventure sports requires a comprehensive explanatory framework, ecological dynamics which considers person-environment interactions from a multidisciplinary perspective. Action and adventure sports can be fundamentally conceptualized as activities which flourish through creative exploration of novel movement experiences, continuously expanding and evolving beyond predetermined environmental, physical, psychological or sociocultural boundaries. The outcome is the emergence of a rich variety of participation styles and philosophical differences within and across activities. The purpose of this paper is twofold: (a) to point out some limitations of existing research on action and adventure sports; (b) based on key ideas from emerging research and an ecological dynamics approach, to propose a holistic multidisciplinary model for defining and understanding action and adventure sports that may better guide future research and practical implications

Feminist phenomenology and the woman in the running body

Modern phenomenology, with its roots in Husserlian philosophy, has been taken up and utilised in a myriad of ways within different disciplines, but until recently has remained relatively under-used within sports studies. A corpus of sociological-phenomenological work is now beginning to develop in this domain, alongside a longer standing literature in feminist phenomenology. These specific social-phenomenological forms explore the situatedness of lived-body experience within a particular social structure. After providing a brief overview of key strands of phenomenology, this article considers some of the ways in which sociological, and particularly feminist phenomenology, might be used to analyse female sporting embodiment. For illustrative purposes, data from an autophenomenographic project on female distance running are also included, in order briefly to demonstrate the application of phenomenology within sociology, as both theoretical framework and methodological approach

Action theory and the value of sport

I present a corrective to the formalist and conventionalist down-playing of physical actions in the understanding of the value of sport. I give a necessarily brief account of the Causal Theory of Action (CTA) and its implications for the normativity of actions. I show that the CTA has limitations, particularly in the case of failed or incomplete actions, and I show that failed or incomplete actions are constitutive of sport. This allows me to open up the space for another model, drawn from Aristotle, for failed or incomplete actions, conceived of as ‘doables’. This avoids some of the problems of the CTA. I explain the importance of difficult but doable actions, at which athletes often fail, and suggest that this establishes pro tanto value. Finally, I claim that this account of the actions that are constitutive of sport deepens our understanding of the value of sport as a whole