85 research outputs found
5-HT2A Receptor Binding in the Frontal Cortex of Parkinson's Disease Patients and Alpha-Synuclein Overexpressing Mice:A Postmortem Study
The 5-HT2A receptor is highly involved in aspects of cognition and executive function and seen to be affected in neurodegenerative diseases like Alzheimerâs disease and related to the disease pathology. Even though Parkinsonâs disease (PD) is primarily a motor disorder, reports of impaired executive function are also steadily being associated with this disease. Not much is known about the pathophysiology behind this. The aim of this study was thereby twofold: (1) to investigate 5-HT2A receptor binding levels in Parkinsonâs brains and (2) to investigate whether PD associated pathology, alpha-synuclein (AS) overexpression, could be associated with 5-HT2A alterations. Binding density for the 5-HT2A-specific radioligand [3H]-MDL 100.907 was measured in membrane suspensions of frontal cortex tissue from PD patients. Protein levels of AS were further measured using western blotting. Results showed higher AS levels accompanied by increased 5-HT2A receptor binding in PD brains. In a separate study, we looked for changes in 5-HT2A receptors in the prefrontal cortex in 52-week-old transgenic mice overexpressing human AS. We performed region-specific 5-HT2A receptor binding measurements followed by gene expression analysis. The transgenic mice showed lower 5-HT2A binding in the frontal association cortex that was not accompanied by changes in gene expression levels. This study is one of the first to look at differences in serotonin receptor levels in PD and in relation to AS overexpression
Konstruktivistische AnsÀtze in der Erwachsenenbildung und Weiterbildung
Theoretical approaches in the field of further education and advanced vocational training have to face multifaceted demands: the analysis of knowledge aquisition and knowledge transfer and its instructional support as well as the revealment of the mechanisms which influence further education on an organisational level in companies. This article describes, that herefore especially moderate constructivistic approaches are useful. After an introduction to the philosophical tradition of these approaches and important characteristics of adult learning, two examples of constructivistic models are being described particularly: The theory of situated learning environments and career counseling. Concluding it is shown, that a moderate constructive perspective fulfils important criteria for the theoretic modelling of further education processes.Theoretische AnsĂ€tze in der Erwachsenen- und insbesondere in der beruflichen Weiterbildung mĂŒssen sich vielfĂ€ltigen AnsprĂŒchen stellen: der Analyse des Wissenserwerbs und Wissenstransfers und seiner instruktionalen UnterstĂŒtzung ebenso wie der Aufdeckung der Mechanismen, die in den Betrieben auf organisatorischer Ebene die Weiterbildung beeinflussen. In diesem Beitrag wird die Auffassung vertreten, daĂ dafĂŒr insbesondere liberalisierte konstruktivistische AnsĂ€tze gut geeignet sind. Nach einer EinfĂŒhrung in die philosophische Tradition dieser AnsĂ€tze und wichtiger Merkmale des Lernens im Erwachsenenalter werden zwei Beispiele konstruktivistischer Modelle genauer beschrieben: die Theorie situierter Lernumgebungen und das career counseling. AbschlieĂend wird gezeigt, daĂ eine liberalisierte konstruktivistische Perspektive wichtige Kriterien fĂŒr die theoretische Modellierung von Weiterbildungsprozessen erfĂŒllt
Developments in the Strategy of Red Locust Plague Prevention in the Fifty-Year History of the International Red Locust Control Organisation for Central and Southern Africa
Towards an understanding of teacher judgement in the context of social moderation
Social moderation involves teachers gathering together to discuss their judgements of the quality of student work and to reach agreement regarding the standard awarded. This qualitative study conducted over a three-year period investigated the social practice of moderation and the influence on teachersâ judgements of students work. An initial survey of teachersâ understandings of moderation and standards, pre-interviews of teachers who participated in the moderation meetings, observations of these meetings with a particular focus on one teacher (focus teachers) comprised the data collection methods. Data analysis involved organising, matching, coding, identifying patterns and themes using a constant comparative method. Socio-cultural theories of learning and assessment underpinned the approach to data analysis and proved helpful in explaining the diverse influences on teachersâ judgements beyond the task criteria, and the progressive development of shared understandings through engaging in professional discussions of studentsâ work. The study revealed that the process is not clear and linear and is influenced by factors such as the representation of the standards and the knowledge base of the teachers
O esporte na cidade : capĂtulos de sua histĂłria em VitĂłria
Organizadores, Ivan Marcelo Gomes, Felipe QuintĂŁo de Almeida, Ueberson Ribeiro Almeida, ClĂĄudia EmĂlia Aguiar Morae
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