53 research outputs found
Magnetic nanostructures by adaptive twinning in strained epitaxial films
We exploit the intrinsic structural instability of the Fe70Pd30 magnetic
shape memory alloy to obtain functional epitaxial films exhibiting a
self-organized nanostructure. We demonstrate that coherent epitaxial straining
by 54% is possible. The combination of thin film experiments and large-scale
first-principles calculations enables us to establish a lattice relaxation
mechanism, which is not expected for stable materials. We identify a low twin
boundary energy compared to a high elastic energy as key prerequisite for the
adaptive nanotwinning. Our approach is versatile as it allows to control both,
nanostructure and intrinsic properties for ferromagnetic, ferroelastic and
ferroelectric materials.Comment: Final version. Supplementary information available on request or at
the publisher's websit
Epitaxial LaFeAsOF thin films grown by pulsed laser deposition
Superconducting and epitaxially grown LaFeAsOF thin films were successfully
prepared on (001)-oriented LaAlO3 substrates using pulsed laser deposition. The
prepared thin films show exclusively a single in-plane orientation with
epitaxial relation (001)[100] parallel to (001)[100] and a FWHM value of 1deg.
Furthermore, resistive measurement of the superconducting transition
temperature revealed a Tc90 of 25K with a high residual resistive ratio of 6.8.
The applied preparation technique, standard thin film pulsed laser deposition
at room temperature in combination with a subsequent post annealing process, is
suitable for fabrication of high quality LaFeAsO1-xFx thin films. A high upper
critical field of 76.2 T was evaluated for magnetic fields applied
perpendicular to the c-axis and the anisotropy was calculated to be 3.3
assuming single band superconductivity.Comment: 6 pages, 4 Figure
Transport and magnetic properties of Co-doped BaFe_{2}As_{2} epitaxial thin films
We report resistivity, Hall coefficient, current-voltage characteristics, and
magneto-optical imaging measurements of epitaxial Co-doped BaFe_{2}As_{2} thin
films deposited on MgO(001) substrate. The Hall resistivity of the films has a
substantial contribution arising from anomalous Hall effect of ferromagnetic
components. The critical current density (J_{c}) of the films is ~2 MA/cm^{2}
at low temperatures. Differential magneto-optical images of the remanent state
give similar J_{c} values and also exhibit presence of extended defects in the
film.Comment: 9 pages, 4 figure
DC superconducting quantum interference devices fabricated using bicrystal grain boundary junctions in Co-doped BaFe2As2 epitaxial films
DC superconducting quantum interference devices (dc-SQUIDs) were fabricated
in Co-doped BaFe2As2 epitaxial films on (La, Sr)(Al, Ta)O3 bicrystal substrates
with 30deg misorientation angles. The 18 x 8 micro-meter^2 SQUID loop with an
estimated inductance of 13 pH contained two 3 micro-meter wide grain boundary
junctions. The voltage-flux characteristics clearly exhibited periodic
modulations with deltaV = 1.4 micro-volt at 14 K, while the intrinsic flux
noise of dc-SQUIDs was 7.8 x 10^-5 fai0/Hz^1/2 above 20 Hz. The rather high
flux noise is mainly attributed to the small voltage modulation depth which
results from the superconductor-normal metal-superconductor junction nature of
the bicrystal grain boundary
Systematic Analysis of Circulating Soluble Angiogenesis-Associated Proteins in ICON7 Identifies Tie2 as a Biomarker of Vascular Progression on Bevacizumab
background: There is a critical need for predictive/resistance biomarkers for VEGF inhibitors to optimise their use. methods: Blood samples were collected during and following treatment and, where appropriate, upon progression from ovarian cancer patients in ICON7, a randomised phase III trial of carboplatin and paclitaxel with or without bevacizumab. Plasma concentrations of 15 circulating angio-biomarkers were measured using a validated multiplex ELISA, analysed through a novel network analysis and their relevance to the PFS then determined. results: Samples (n=650) were analysed from 92 patients. Bevacizumab induced correlative relationships between Ang1 and Tie2 plasma concentrations, which reduced after initiation of treatment and remained decreased until progressive disease occurred. A 50% increase from the nadir in the concentration of circulating Tie2 (or the product of circulating Ang1 and Tie2) predicted tumour progression. Combining Tie2 with GCIG-defined Ca125 data yielded a significant improvement in the prediction of progressive disease in patients receiving bevacizumab in comparison with Ca125 alone (74.1% vs 47.3%, P<1 × 10−9). conclusions: Tie2 is a vascular progression marker for bevacizumab-treated ovarian cancer patients. Tie2 in combination with Ca125 provides superior information to clinicians on progressive disease in patients with VEGFi-treated ovarian cancers
Point-contact study of ReFeAs(1-x)Fx (Re=La, Sm) superconducting films
Point-contact (PC) Andreev-reflection (AR) measurements of the
superconducting gap in iron-oxipnictide ReFeAsO_{1-x}F_x (Re=La, Sm) films have
been carried out. The value of the gap is distributed in the range 2\Delta
\simeq 5-10 meV (for Re=Sm) with a maximum in the distribution around 6 meV.
Temperature dependence of the gap \Delta(T) can be fitted well by BCS curve
giving reduced gap ratio 2\Delta /kT_c^*\simeq 3.5 (here T_c^* is the critical
temperature from the BCS fit). At the same time, an expected second larger gap
feature was difficult to resolve distinctly on the AR spectra making
determination reliability of the second gap detection questionable. Possible
reasons for this and the origin of other features like clear-cut asymmetry in
the AR spectra and current regime in PCs are discussed.Comment: 6 two-column pages, 6 figs., 26 Refs., to be published in
Superconductor Science and Technolog
Epitaxial growth and anisotropy of La(O,F)FeAs thin films deposited by Pulsed Laser Deposition
LaFeAsO1-xFx thin films were deposited successfully on (001)-oriented LaAlO3
and MgO substrates from stoichiometric LaFeAsO1-xFx polycrystalline targets
with fluorine concentrations up to x = 0.25 by PLD. Room temperature deposition
and post annealing of the films yield nearly phase pure films with a pronounced
c-axis texture and a strong biaxial in-plane orientation. Transport
measurements show metallic resistance and onset of superconductivity at 11 K.
Hc2(T) was determined by resistive measurements and yield Hc2 values of 3 T at
3.6 K for B||c and 6 T at 6.4 K for B||ab.Comment: 11 pages, 5 figure
Thin Film Growth and Device Fabrication of Iron-Based Superconductors
Iron-based superconductors have received much attention as a new family of
high-temperature superconductors owing to their unique properties and distinct
differences from cuprates and conventional superconductors. This paper reviews
progress in thin film research on iron-based superconductors since their
discovery for each of five material systems with an emphasis on growth,
physical properties, device fabrication, and relevant bulk material properties.Comment: To appear in J. Phys. Soc. Jp
Biomarkers of apoptosis
Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the drug development cycle, especially in the clinic. Selective activation of apoptosis is often cited as one of the major goals of cancer chemotherapy. Thus, the present minireview focuses on a discussion of the pros and cons of a variety of methodological approaches to detect different components of the apoptotic cascade as potential biomarkers of programmed cell death. The bulk of the discussion centres on serological assays utilising the technique of ELISA, since here there is an obvious advantage of sampling multiple time points. Potential biomarkers of apoptosis including circulating tumour cells, cytokeratins and DNA nucleosomes are discussed at length. However, accepting that a single biomarker may not have the power to predict proof of concept and patient outcome, it is clear that in the future more emphasis will be placed on technologies that can analyse panels of biomarkers in small volumes of samples. To this end the increased throughput afforded by multiplex ELISA technologies is discussed
Issues on fit-for-purpose validation of a panel of ELISAs for application as biomarkers in clinical trials of anti-Angiogenic drugs
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