4 research outputs found
Mechanisms and in vivo functions of contact inhibition of locomotion
Contact inhibition of locomotion (CIL) is a process whereby a cell ceases motility or
changes its trajectory upon collision with another cell. CIL was initially characterized more than
half a century ago and became a widely studied model system to understand how cells migrate
and dynamically interact. Although CIL fell from interest for several decades, the scientific
community has recently rediscovered this process. We are now beginning to understand the
precise steps of this complex behaviour and to elucidate its regulatory components, including
receptors, polarity proteins and cytoskeletal elements. Furthermore, this process is no longer just
in vitro phenomenology; we now know from several different in vivo models that CIL is essential
for embryogenesis and in governing behaviours such as cell dispersion, boundary formation and
collective cell migration. In addition, changes in CIL responses have been associated with other
physiological processes, such as cancer cell dissemination during metastasis
Community outbreak of hemolytic uremic syndrome attributable to Escherichia Coli O111:NM - South Australia, 1995
http://www.cdc.gov/mmwr/preview/mmwrhtml/00038232.ht