Development of Cloud-Based Microservices to Decision Support System

Intelligent systems of simulation become a key stage of the scheduling of companies and industries work. Most of the existing decision support systems are desktop software. Today there is a need to use durability, flexibility, availability and crossplatforming information technologies. The paper proposes the idea of working cloud based decision support system BPsim.Web and this one consists of some set of services and tools. The model of the multiagent resources conversion process is considered. The process of the simulation model developing via BPsim.Web is described. An example of the real process model is given. © 2020, IFIP International Federation for Information Processing.Russian Foundation for Basic Research, RFBR: 18-37-00183The reported study was funded by RFBR according to the research project № 18-37-00183

Development of graphical oriented expert system

In this paper the application of expert system apparatus is described of the balanced score card method based on production model of knowledge representation. The proposed approach to creating the Balanced Score Card model automates processes of analyzing the impact of changes in the key indicators and sponsored activities was carried out. Also, the approach enhances estimating the cost of resources necessary to achieve the key indicator taking into accountthe coefficients of confidence in certain dependencies and baseline data. © 2020 American Institute of Physics Inc.. All rights reserved.This work was supported by Act 211 Government of the Russian Federation, contract N 02.A03.21.0006

Development of a Text Analysis Agent for the Subject Area "Train Schedule"

In this article, on the basis of multiple inputs of possible questions concerning the subject area "Train Schedule" from the users, the accuracy of the definition of the request by the chatbot Twin and the accuracy of the response are checked

Development of a Text Analysis Agent for a Logistics Company's Q&A System

The "Twin" system is an omnichannel communication platform for building voice and chatbots, capable, in particular, of receiving data in one language and transmitting in another. "Twin" can record voice and text, display detailed statistics and analytics for each call or dialog. In this article, using the Twin system, a chatbot was created for the field of cargo transportation, it describes its advantages and disadvantages and the principle of creating of such chatbots. © 2021 Institute of Physics Publishing. All rights reserved

Development of a Question and Answer for the Subject Area "Management of a Metallurgical Plant"

In this article, based on multiple tests, concerning the subject area “Management of a metallurgical plant”, the precision of the requests by users and the results given in the chatbots proved that there were some errors. The results showed that the system could not always give the accurate results.I would like to thank my supervisor Mr. Aksyonov K. A. for guiding me through my research

Application of multi-agent approach in the electric power control systems within the active energy complex

This paper provides an analytical overview of artificial intelligence technologies used in the tasks of technological management of the electric power industry. The relevance of using multi-agent systems is proved for solving energy problems. The concept of an intelligent energy system is considered with an active adaptive network (IES AAN). A block diagram of the electric power system management system is given within the IES AAN. It is shown that the developed centralized management principles are not fully applicable for small distribution networks - microgrid, with the use of storage devices and renewable sources. The article describes the active energy complex in Russia in the context of an analog of the Microgrid concept. The required functionality of a intelligent controllable connection (ICC) is studied, the main algorithm of the ICC operation is given, and the proposed structure is described for building a distributed system of intelligent multi-agent control of the AEC that implements the required functions. © Published under licence by IOP Publishing Ltd

Deployment of Software-Controlled Distributed Laboratory Complex for a Higher Educational Institution

The intensive development of information systems and communication infrastructures has led to the emergence of new approaches and new tools for their management. Cloud services, virtualization technologies and software-based management tools are actively used today for building modern information systems which provides additional opportunities for managing components of these systems and for expanding such systems abilities. The use of such approaches and tools can provide a solution to the complex of problems faced by education institutions today, presenting new methods of distance learning and new forms of practical training. The balanced use of virtualization technologies and software-based control tools allows building distributed laboratory complexes of a new generation which will provide new possibilities for using the equipment that is available in educational institutions. The use of such complexes in the educational process allows not only to instill in students the skills of managing the configurations of communication infrastructures that are especially relevant today, but also to organize, in addition to traditional laboratory work, new forms of contactless practical classes. When conducting such classes, students get the opportunity to fully-functional remote access to the virtual and physical components of the complex, which is especially important for organizing the educational process in modern conditions associated with the COVID-19 pandemic. The article discusses modern approaches to the construction of software-controlled communication infrastructures, tools for software-based management of their components and also, an example of the implementation of these approaches and such tools usage in the construction of a distributed laboratory complex for a higher educational institution. The main advantages of the approach based on the use of hypervisors and emulators are presented, the experience of its deployment in the modernization of the laboratory complex for a IRIT-RTF UrFU is considered. © 2021 Institute of Physics Publishing. All rights reserved.This work is supported by Act 211 Government of the Russian Federation, contract № 02.A03.21.000

Сравнительный анализ диагностической значимости панелей биомаркеров у реципиентов сердца в отдаленные сроки после трансплантации

Aim. To perform comparative analysis of the diagnostic efficacy of sCD40L, PDGF-BB, VEGF-A and ST2 in recipients with cardiac rejection in different periods after transplantation. Materials and methods. The study included 144 cardiac recipients aged from 12 to 71 (mean age 44 ± 14) years old, among those 112 were men. Venous blood plasma taken on the same day with endomyocardial biopsy was used for the study. The concentrations of soluble CD40 ligand (sCD40L), vascular endothelial growth factor (VEGF-A), platelet-derived growth factor (PDGF-BB) were measured using xMAP technology. The concentrations of ST2 were measured by ELISA. Results. Men had significantly higher levels of ST2 and VEGF-A compared to women (p = 0.03). No correlation was found between the levels of biomarkers (sCD40L, PDGF-BB, VEGF-A, ST2) and age, diagnosis before transplantation, presence of arterial hypertension and diabetes mellitus. Comparative analysis of the biomarkers’ levels didn’t show significant difference between patients with heart transplant rejection and without it in the first month and in the first year after transplantation. The ST2 level was significantly higher in patients with heart rejection (p = 0.01) in the long term period (1–5 years) after transplantation compared to patients without rejection. Relative risk of cardiac transplant rejection was significantly higher in patients with high (>22.8 ng/ml) ST2 level (RR = 2.59 ± 0.33; Se – 35%, Sp – 93%). However, its combination with other biomarkers improved their diagnostic value. Relative risk for panel including ST2, VEGF-A and PDGF-BB 3.47 ± 0.55, Se – 57%, Sp – 91%; relative risk for panel including ST2, sCD40L and PDGF-BB was 3.75 ± 0.59, Se – 50%, Sp – 92%. The highest diagnostic efficacy for the heart transplant rejection was reached by a panel of biomarkers that included ST2 and PDGF-BB (RR = 5.0 ± 0.56 [95% CI 1.68–14.92], Se – 63%, Sp – 94%). Conclusion. ST2 had the biggest diagnostic value for heart transplant rejection in the long term period after heart transplantation. Its usage as a part of complex tests with other biomarkers improves the sensitivity of noninvasive diagnosis of the cardiac rejection. The highest diagnostic significance for cardiac transplant rejection in the long term period was shown by a panel of ST2 and PDGF-BB.Цель. Выполнить сравнительный анализ диагностической эффективности sCD40L, PDGF-BB, VEGF-A и ST2 в составе панелей биомаркеров при отторжении трансплантированного сердца в различные сроки после трансплантации. Материалы и методы. В исследование включены 144 реципиента сердца в возрасте от 12 до 71 (44 ± 14) года, из них 112 мужчин. Концентрацию цитокинов измеряли в плазме периферической крови пациентов, взятой в день эндомиокардиальной биопсии. Уровень растворимой формы лиганда CD40 (sCD40L), фактора роста эндотелия сосудов (VEGF-A), фактора роста тромбоцитов (PDGF-BB), измеряли с использованием мультиплексной технологии; уровень стимулирующего фактора роста ST2 – с помощью иммуноферментного анализа. Результаты. Уровень ST2 и VEGF-A был достоверно выше у мужчин, чем у женщин (p = 0,03). Уровни исследуемых биомаркеров не зависели от возраста, диагноза до трансплантации сердца (ТС), наличия артериальной гипертонии, сахарного диабета II типа. Сравнительный анализ уровней биомаркеров не показал достоверной разницы у пациентов с наличием отторжения сердечного трансплантата и без такового в первый месяц и в первый год после ТС. Концентрация ST2 была достоверно выше у пациентов с отторжением сердца, чем без такового, в отдаленные сроки (1–5 лет) после ТС (p = 0,01). Относительный риск развития отторжения трансплантированного сердца в отдаленные сроки после ТС у пациентов с концентрацией ST2, превышающей значение медианы (22,8 нг/мл), в 2,6 раза выше, чем у пациентов с концентрацией цитокина ниже медианы (чувствительность – 35%, специфичность – 93%). ST2 в составе панелей биомаркеров увеличивает их диагностическую значимость: для панели, включающей ST2, PDGF-BB и VEGF-A, относительный риск составлял 3,47 ± 0,55 (чувствительность – 57%, специфичность – 91%); для панели, включающей ST2, PDGF-BB и sCD40L – 3,75 ± 0,59 (чувствительность – 50%, специфичность – 92%) Сочетание ST2 и PDGF-BB обладало наибольшей диагностической значимостью (RR = 5,00 ± 0,56 [95% ДИ 1,68–14,92]; чувствительность – 63%, специфичность – 94%). Заключение. Наибольшей диагностической значимостью при отторжении трансплантированного сердца в отдаленные сроки после трансплантации обладает ST2, и его применение в составе комплексных тестов с другими биомаркерами позволяет улучшить чувствительность неинвазивной диагностики отторжения. Наибольшей диагностической значимостью в отдаленные сроки после ТС обладает панель из двух биомаркеров: ST2 и PDGF-BB

A meta-analysis of the relationship between brain dopamine receptors and obesity: a matter of changes in behavior rather than food addiction?

Addiction to a wide range of substances of abuse has been suggested to reflect a ‘Reward Deficiency Syndrome'. That is, drugs are said to stimulate the reward mechanisms so intensely that, to compensate, the population of dopamine D(2) receptors (DD2R) declines. The result is that an increased intake is necessary to experience the same degree of reward. Without an additional intake, cravings and withdrawal symptoms result. A suggestion is that food addiction, in a similar manner to drugs of abuse, decrease DD2R. The role of DD2R in obesity was therefore examined by examining the association between body mass index (BMI) and the Taq1A polymorphism, as the A1 allele is associated with a 30–40% lower number of DD2R, and is a risk factor for drug addiction. If a lower density of DD2R is indicative of physical addiction, it was argued that if food addiction occurs, those with the A1 allele should have a higher BMI. A systematic review found 33 studies that compared the BMI of those who did and did not have the A1 allele. A meta-analysis of the studies compared those with (A1/A1 and A1/A2) or without (A2/A2) the A1 allele; no difference in BMI was found (standardized mean difference 0.004 (s.e. 0.021), variance 0.000, Z=0.196, P<0.845). It was concluded that there was no support for a reward deficiency theory of food addiction. In contrast, there are several reports that those with the A1 allele are less able to benefit from an intervention that aimed to reduce weight, possibly a reflection of increased impulsivity

ДИАГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ ТРОМБОЦИТАРНОГО ФАКТОРА РОСТА PDGF-BB И ST2 ПРИ ОТТОРЖЕНИИ ТРАНСПЛАНТИРОВАННОГО СЕРДЦА

Aim: to determine the association between plasma concentrations of biomarkers (sCD40L, PDGF-BB, PlGF-1, ST2) with histochemical and immunohistochemical signs of heart rejection.Materials and methods. The study included 98 heart recipients aged from 12 to 69 (mean age 43 ± 14) years, of which 78 men. In 68 patients dilated cardiomyopathy was diagnosed, 30 recipients were diagnosed with coronary heart disease. The concentrations of placental growth factor (PlGF-1), platelet-derived growth factor (PDGF-BB), soluble CD40 ligand (sCD40L) were measured using xMAP technology. The concentrations of ST2 cardiac biomarker were measured by ELISA.Results. No correlation was found between the levels of biomarkers (sCD40L, PDGF-BB, PlGF-1, ST2) and gender, age and diagnosis. The rejection was diagnosed via biopsy in 49 biopsies taken from 37 recipients. 1A rejection was found in 25 patients (34 biopsies), 1B rejection was identifi ed in 2 patients (3 biopsies), 3A rejection was diagnosed in 4 patients. Immunohistochemical signs of humoral rejection were identifi ed in 3 patients. The combination of acute cellular and humoral rejection was found in 4 patients (5 biopsies). The PDGFBB level was measured at the same day as the biopsy was taken, and it was shown to be signifi cantly higher in patients with rejection (p = 0.02). Rejection frequency was signifi cantly higher in patients with high PDGF-BB level (≥2473.7 pg/ml, RR = 1.64 ± 0.23; 95% CI [1.03–2.61]). Rejection frequency increased to 2.11 ± 0.34 [95% CI [1.08–4.11]] in recipients with ST2 and PDGF-BB concentration higher than the median value. The highest predictive value for heart rejection can be reached by a panel of three biomarkers: sCD40L, PlGF-1 and ST2 (RR = 2.51 ± 0.38; 95% CI [1.18–5.3]).Conclusion. PDGF-BB has moderate predictive value for heart rejection. The highest predictive value for heart rejection was reached by a panel of three biomarkers: sCD40L, PlGF-1 and ST2.Цель: определить связь концентрации биомаркеров sCD40L, PDGF-BB, PlGF-1, ST2 в плазме крови реципиентов сердца с наличием и выраженностью гистохимических и иммуногистохимических признаков отторжения сердечного трансплантата.Материалы и методы. В исследование включены 98 пациентов с трансплантированным сердцем в возрасте от 12 до 69 (43 ± 14) лет, из них 78 мужчин. У 68 реципиентов до трансплантации сердца была диагностирована дилатационная кардиомиопатия, у 30 – ишемическая болезнь сердца. Концентрацию плацентарного фактора роста (PlGF-1), фактора роста тромбоцитов (PDGF-BB), растворимой формы лиганда CD40 (sCD40L) измеряли с использованием мультиплексной технологии; концентрацию стимулирующего фактора роста ST2 – с помощью иммуноферментного анализа.Результаты. Концентрация каждого биомаркера не зависела от пола, возраста и диагноза до трансплантации. У 37 пациентов (по результатам 49 биопсий) были диагностированы признаки отторжения. Гистохимические признаки острого клеточного отторжения – у 30 реципиентов (в 41 биоптате): 1А – у 25 пациентов (в 34 биоптатах), 1В – у двух пациентов (в трех биоптатах), 3А – у четырех пациентов. Иммуногистохимические признаки антителоопосредованного отторжения выявлены у трех пациентов. Сочетание острого клеточного и гуморального отторжения обнаружено у четырех пациентов (в пяти биоптатах). Концентрация PDGF-BB, измеренная в день эндомиокардиальной биопсии, была достоверно выше у пациентов с отторжением (p = 0,02). У реципиентов сердца с уровнем PDGF-BB выше медианы (2473,7 пг/мл) риск отторжения был в 1,64 раза выше, чем у пациентов с уровнем ниже медианы. У реципиентов с концентрацией и ST2, и PDGF-BB, превышающей значения медианы, относительный риск отторжения возрастал до 2,11 ± 0,34 [95% ДИ 1,08–4,11]. Наибольшей диагностической значимостью в отношении отторжения трансплантата обладала панель из трех биомаркеров (sCD40L, PlGF-1, ST2): RR = 2,51 ± 0,38 [95% ДИ 1,18–5,3].Заключение. PDGF-BB обладает умеренной прогностической значимостью в отношении отторжения трансплантированного сердца. Наибольшей диагностической значимостью обладает панель из трех биомаркеров: sCD40L, PlGF-1, ST2