4,109 research outputs found
On the possible role of PIF in myofibrillar proteins mobilisation from skeletal muscles in the presence of non-malignant foci of growth in organism
Reporting of child maltreatment during the SARS-CoV-2 pandemic in New York City from March to May 2020
© 2020 Elsevier Ltd Background: School closures and other public health responses have decreased the extent that children interact with mandated reporters and other professionals trained to detect child maltreatment. Objective: To assess associations between the pandemic public health response and the number of allegations of child abuse or neglect. Methods: This study analyzed monthly data from New York City of the number of child maltreatment allegations, stratified by reporter type (e.g., mandated reporter, education personnel, healthcare personnel), as well as the number of Child Protective Services (CPS) investigations warranting child welfare preventative services. SARIMA models were trained using data from January 2015 to February 2020 to predict expected values for March, April, and May 2020. Observed values were compared against predicted values at an alpha of .05. Results: Substantially fewer allegations of child maltreatment were reported than expected in March (-28.8 %, deviation: 1848, 95 % CI: [1272, 2423]), April (-51.5 %, deviation: 2976, 95 % CI: [2382, 3570]), and May 2020 (-46.0 %, deviation: 2959, 95 % CI: [2347, 3571]). Significant decreases in child maltreatment reporting were also noted for all reporter subtypes examined for March, April, and May 2020. Fewer CPS investigations warranted preventative services than expected in March 2020 (-43.5 %, deviation: 303, 95 % CI: [132, 475]). Conclusions: Precipitous drops in child maltreatment reporting and child welfare interventions coincided with social distancing policies designed to mitigate COVID-19 transmission. In light of these findings, educators and healthcare providers must be especially vigilant when engaging online with children and their families for signs of child abuse and/or neglect
Non-ergodicity of the motion in three dimensional steep repelling dispersing potentials
It is demonstrated numerically that smooth three degrees of freedom
Hamiltonian systems which are arbitrarily close to three dimensional strictly
dispersing billiards (Sinai billiards) have islands of effective stability, and
hence are non-ergodic. The mechanism for creating the islands are corners of
the billiard domain.Comment: 6 pages, 8 figures, submitted to Chao
Growing Scale-Free Networks with Tunable Clustering
We extend the standard scale-free network model to include a ``triad
formation step''. We analyze the geometric properties of networks generated by
this algorithm both analytically and by numerical calculations, and find that
our model possesses the same characteristics as the standard scale-free
networks like the power-law degree distribution and the small average geodesic
length, but with the high-clustering at the same time. In our model, the
clustering coefficient is also shown to be tunable simply by changing a control
parameter - the average number of triad formation trials per time step.Comment: Accepted for publication in Phys. Rev.
Controlling cluster synchronization by adapting the topology
We suggest an adaptive control scheme for the control of zero-lag and cluster
synchronization in delay-coupled networks. Based on the speed-gradient method,
our scheme adapts the topology of a network such that the target state is
realized. It is robust towards different initial condition as well as changes
in the coupling parameters. The emerging topology is characterized by a
delicate interplay of excitatory and inhibitory links leading to the
stabilization of the desired cluster state. As a crucial parameter determining
this interplay we identify the delay time. Furthermore, we show how to
construct networks such that they exhibit not only a given cluster state but
also with a given oscillation frequency. We apply our method to coupled
Stuart-Landau oscillators, a paradigmatic normal form that naturally arises in
an expansion of systems close to a Hopf bifurcation. The successful and robust
control of this generic model opens up possible applications in a wide range of
systems in physics, chemistry, technology, and life science
Network dynamics of ongoing social relationships
Many recent large-scale studies of interaction networks have focused on
networks of accumulated contacts. In this paper we explore social networks of
ongoing relationships with an emphasis on dynamical aspects. We find a
distribution of response times (times between consecutive contacts of different
direction between two actors) that has a power-law shape over a large range. We
also argue that the distribution of relationship duration (the time between the
first and last contacts between actors) is exponentially decaying. Methods to
reanalyze the data to compensate for the finite sampling time are proposed. We
find that the degree distribution for networks of ongoing contacts fits better
to a power-law than the degree distribution of the network of accumulated
contacts do. We see that the clustering and assortative mixing coefficients are
of the same order for networks of ongoing and accumulated contacts, and that
the structural fluctuations of the former are rather large.Comment: to appear in Europhys. Let
Increased Expression of Tissue Factor and Receptor for Advanced Glycation End Products in Peripheral Blood Mononuclear Cells of Patients With Type 2 Diabetes Mellitus with Vascular Complications
The aim of the study was to determine the correlation between
the expression of tissue factor (TF) and the receptor
for advanced glycation end products (RAGEs) and vascular
complications in patients with longstanding uncontrolled
type 2 diabetes (T2D). TF and RAGE mRNAs as well as
TF antigen and activity were investigated in 21 T2D patients
with and without vascular complications. mRNA expression
was assessed by reverse transcriptaseâpolymerase
chain reaction (RT-PCR) in nonstimulated and advanced
glycation end product (AGE) albuminâstimulated peripheral
blood mononuclear cells (PBMCs). TF antigen expression
was determined by enzyme-linked immunosorbent assay
(ELISA) and TF activity by a modified prothrombin
time assay. Basal RAGE mRNA expression was 0.2 ± 0.06
in patients with complications and 0.05 ± 0.06 patients without
complications (P = .004). Stimulation did not cause any
further increase in either group. TF mRNA was 0.58 ± 0.29
in patients with complications and 0.21 ± 0.18 in patients
without complications (P = .003). Stimulation resulted in
a nonsignificant increase in both groups. Basal TF activity
(U/106 PBMCs) was 18.4 ± 13.2 in patients with complications
and 6.96 ± 5.2 in patients without complications (P =
.003). It increased 3-fold in both groups after stimulation
(P = .001). TF antigen (pg/106 PBMCs) was 33.7 ± 28.6 in
patients with complications, 10.4 ± 7.8 in patients without complications (P = .02). Stimulation tripled TF antigen in
both groups of patients (P = .001). The RAGE/TF axis is
up-regulated inT2Dpatients with vascular complications as
compared to patients without complications. This suggests
a role for this axis in the pathogenesis of vascular complications
in T2D
Two-Photon 2s<->1s Transitions during Recombination of Hydrogen in the Universe
Based on the standard cosmological model, we calculate the correction to the
rate of two-photon 2s1s transitions in the hydrogen atom under primordial
hydrogen plasma recombination conditions that arises when the induced
transitions under equilibrium background radiation with a blackbody spectrum
and plasma recombination radiation are taken into account.Comment: 20 pages, 9 figure
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