Majorana spinors and extended Lorentz symmetry in four-dimensional theory

An extended local Lorentz symmetry in four-dimensional (4D) theory is considered. A source of this symmetry is a group of general linear transformations of four-component Majorana spinors GL(4,M) which is isomorphic to GL(4,R) and is the covering of an extended Lorentz group in a 6D Minkowski space M(3,3) including superluminal and scaling transformations. Physical space-time is assumed to be a 4D pseudo-Riemannian manifold. To connect the extended Lorentz symmetry in the M(3,3) space with the physical space-time, a fiber bundle over the 4D manifold is introduced with M(3,3) as a typical fiber. The action is constructed which is invariant with respect to both general 4D coordinate and local GL(4,M) spinor transformations. The components of the metric on the 6D fiber are expressed in terms of the 4D pseudo-Riemannian metric and two extra complex fields: 4D vector and scalar ones. These extra fields describe in the general case massive particles interacting with an extra U(1) gauge field and weakly interacting with ordinary particles, i.e. possessing properties of invisible (dark) matter.Comment: 24 page

Improved photometry of SDSS crowded field images: Structure and dark matter content in the dwarf spheroidal galaxy Leo I

We explore how well crowded field point-source photometry can be accomplished with SDSS data: We present a photometric pipeline based on DoPhot, and tuned for analyzing crowded-field images from the SDSS. Using Monte Carlo simulations we show that the completeness of source extraction is above 80% to i < 21 (AB) and a stellar surface density of about 200 sq.amin. Hence, a specialized data pipeline can efficiently be used for e.g. nearby resolved galaxies in SDSS images, where the standard SDSS photometric package Photo, when applied in normal survey mode, gives poor results. We apply our pipeline to an area of about 3.55sq.deg. around the dwarf spheroidal galaxy (dSph) Leo I, and construct a high S/N star-count map of Leo I via an optimized filter in color-magnitude space (g,r,i). Although the radial surface-density profile of the dwarf deviates from the best fit empirical King model towards outer radii, we find no evidence for tidal debris out to a stellar surface-density of 4*10^(-3) of the central value. We determine the total luminosity of Leo I, and model its mass using the spherical and isotropic Jeans equation. Assuming that 'mass follows light' we constrain a lower limit of the total mass of the dSph to be (1.7+/-0.2)*10^7 Msol. Contrary, if the mass in Leo I is dominated by a constant density dark-matter (DM) halo, then the mass within the central 12' is (2+/-0.6)*10^8 Msol. This leads to a mass-to-light ratio of >>6 (Ic_sol), and possibly >75 if the DM halo dominates the mass and extends further out than 12'. In summary, our results show that Leo I is a symmetric, relaxed and bound system; this supports the idea that Leo I is a dark-matter dominated system.Comment: 13 pages, 11 figures; accepted for publication in A

Au-Ag template stripped pattern for scanning probe investigations of DNA arrays produced by Dip Pen Nanolithography

We report on DNA arrays produced by Dip Pen Nanolithography (DPN) on a novel Au-Ag micro patterned template stripped surface. DNA arrays have been investigated by atomic force microscopy (AFM) and scanning tunnelling microscopy (STM) showing that the patterned template stripped substrate enables easy retrieval of the DPN-functionalized zone with a standard optical microscope permitting a multi-instrument and multi-technique local detection and analysis. Moreover the smooth surface of the Au squares (abput 5-10 angstrom roughness) allows to be sensitive to the hybridization of the oligonucleotide array with label-free target DNA. Our Au-Ag substrates, combining the retrieving capabilities of the patterned surface with the smoothness of the template stripped technique, are candidates for the investigation of DPN nanostructures and for the development of label free detection methods for DNA nanoarrays based on the use of scanning probes.Comment: Langmuir (accepted

Star complexes and stellar populations in NGC 6822 - Comparison with the Magellanic Clouds

The star complexes (large scale star forming regions) of NGC 6822 were traced and mapped and their size distribution was compared with the size distribution of star complexes in the Magellanic Clouds (MCs). Furthermore, the spatial distributions of different age stellar populations were compared with each other. The star complexes of NGC 6822 were determined by using the isopleths, based on star counts, of the young stars of the galaxy, using a statistical cutoff limit in density. In order to map them and determine their geometrical properties, an ellipse was fitted to every distinct region satisfying this minimum limit. The Kolmogorov-Smirnov statistical test was used to study possible patterns in their size distribution. Isopleths were also used to study the stellar populations of NGC 6822. The star complexes of NGC 6822 were detected and a list of their positions and sizes was produced. Indications of hierarchical star formation, in terms of spatial distribution, time evolution and preferable sizes were found in NGC 6822 and the MCs. The spatial distribution of the various age stellar populations has indicated traces of an interaction in NGC 6822, dated before 350 +/- 50 Myr.Comment: 10 pages, 7 figures, accepted by A&A; minor typeface correction

Shared decision making in patients with low risk chest pain: prospective randomized pragmatic trial.

OBJECTIVE: To compare the effectiveness of shared decision making with usual care in choice of admission for observation and further cardiac testing or for referral for outpatient evaluation in patients with possible acute coronary syndrome. DESIGN: Multicenter pragmatic parallel randomized controlled trial. SETTING: Six emergency departments in the United States. PARTICIPANTS: 898 adults (aged \u3e17 years) with a primary complaint of chest pain who were being considered for admission to an observation unit for cardiac testing (451 were allocated to the decision aid and 447 to usual care), and 361 emergency clinicians (emergency physicians, nurse practitioners, and physician assistants) caring for patients with chest pain. INTERVENTIONS: Patients were randomly assigned (1:1) by an electronic, web based system to shared decision making facilitated by a decision aid or to usual care. The primary outcome, selected by patient and caregiver advisers, was patient knowledge of their risk for acute coronary syndrome and options for care; secondary outcomes were involvement in the decision to be admitted, proportion of patients admitted for cardiac testing, and the 30 day rate of major adverse cardiac events. RESULTS: Compared with the usual care arm, patients in the decision aid arm had greater knowledge of their risk for acute coronary syndrome and options for care (questions correct: decision aid, 4.2 v usual care, 3.6; mean difference 0.66, 95% confidence interval 0.46 to 0.86), were more involved in the decision (observing patient involvement scores: decision aid, 18.3 v usual care, 7.9; 10.3, 9.1 to 11.5), and less frequently decided with their clinician to be admitted for cardiac testing (decision aid, 37% v usual care, 52%; absolute difference 15%; P CONCLUSIONS: Use of a decision aid in patients at low risk for acute coronary syndrome increased patient knowledge about their risk, increased engagement, and safely decreased the rate of admission to an observation unit for cardiac testing.Trial registration ClinicalTrials.gov NCT01969240

Mitochondrial Activity and Cyr1 are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways

Candida albicans is both a major fungal pathogen and a member of the commensal human microflora. The morphological switch from yeast to hyphal growth is associated with disease and many environmental factors are known to influence the yeast-to-hyphae switch. The Ras1-Cyr1-PKA pathway is a major regulator of C. albicans morphogenesis as well as biofilm formation and white-opaque switching. Previous studies have shown that hyphal growth is strongly repressed by mitochondrial inhibitors. Here, we show that mitochondrial inhibitors strongly decreased Ras1 GTP-binding and activity in C. albicans and similar effects were observed in other Candida species. Consistent with there being a connection between respiratory activity and GTP-Ras1 binding, mutants lacking complex I or complex IV grew as yeast in hypha-inducing conditions, had lower levels of GTP-Ras1, and Ras1 GTP-binding was unaffected by respiratory inhibitors. Mitochondria-perturbing agents decreased intracellular ATP concentrations and metabolomics analyses of cells grown with different respiratory inhibitors found consistent perturbation of pyruvate metabolism and the TCA cycle, changes in redox state, increased catabolism of lipids, and decreased sterol content which suggested increased AMP kinase activity. Biochemical and genetic experiments provide strong evidence for a model in which the activation of Ras1 is controlled by ATP levels in an AMP kinase independent manner. The Ras1 GTPase activating protein, Ira2, but not the Ras1 guanine nucleotide exchange factor, Cdc25, was required for the reduction of Ras1-GTP in response to inhibitor-mediated reduction of ATP levels. Furthermore, Cyr1, a well-characterized Ras1 effector, participated in the control of Ras1-GTP binding in response to decreased mitochondrial activity suggesting a revised model for Ras1 and Cyr1 signaling in which Cyr1 and Ras1 influence each other and, together with Ira2, seem to form a master-regulatory complex necessary to integrate different environmental and intracellular signals, including metabolic status, to decide the fate of cellular morphology

The Physics of Maxwell's demon and information

Maxwell's demon was born in 1867 and still thrives in modern physics. He plays important roles in clarifying the connections between two theories: thermodynamics and information. Here, we present the history of the demon and a variety of interesting consequences of the second law of thermodynamics, mainly in quantum mechanics, but also in the theory of gravity. We also highlight some of the recent work that explores the role of information, illuminated by Maxwell's demon, in the arena of quantum information theory.Comment: 24 pages, 13 figures. v2: some refs added, figs improve

Implementation and Performance of the tau trigger in the ATLAS experiment

Triggering on hadronic taus at the LHC is a difficult task due to the high rate and occupancy of the events. On the other hand, the tau trigger increases the discovery potential of ATLAS in many physics channels, among others the Standard Model or SuperSymmetric Higgs (charged or neutrals) production. In order to cope with the rate and optimize the efficiency on important physics channels, the results of the current simulation studies indicate that the ATLAS tau trigger should be used either with relatively high transverse momentum thresholds alone, or with more relaxed threshold requirements in combination with other triggers, like the missing transverse energy trigger or a leptonic or jet trigger. In this contribution we describe the ATLAS tau trigger, and we present some of the current results from the simulation studies, focusing both on early physics and on physics at high luminosity